公开(公告)号：US20240165218A1

公开(公告)日：2024-05-23

申请号：US18359154

申请日：2023-07-26

Applicant: University of Washington

Inventor： Neil King ,  David Baker ,  Lance Stewart ,  Brooke Fiala ,  Daniel Ellis ,  Lauren Carter ,  Rashmi Ravichandran ,  George Ueda ,  Jorge Fallas ,  Una Natterman

IPC: A61K39/12 ,  C12N15/86

CPC classification number: A61K39/12 ,  C12N15/86 ,  B82Y5/00

Abstract: The present disclosure provides nanostructures and nanostructure-based vaccines. Some nanostructures of the present disclosure display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens. Some vaccines of the present disclosure are useful for preventing or decreasing the severity of infection with an infectious agent, including. for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus. flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means disclosed herein. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins. vaccine compositions, and methods of administration.

公开(公告)号：US20180137234A1

公开(公告)日：2018-05-17

申请号：US15813872

申请日：2017-11-15

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: G06F19/12 ,  A61K38/03

CPC classification number: G16B5/00 ,  A61K38/03 ,  C07K14/00 ,  G16B15/30

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

公开(公告)号：US12275757B2

公开(公告)日：2025-04-15

申请号：US18337881

申请日：2023-06-20

Applicant: University of Washington ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. King ,  David Baker ,  Brooke Fiala ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli ,  Jorge Fallas ,  Yang Hsia

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/155 ,  A61K39/385 ,  A61P31/14 ,  B82Y5/00 ,  C07K14/005 ,  C12N7/00

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructure; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US12194075B2

公开(公告)日：2025-01-14

申请号：US17028377

申请日：2020-09-22

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: C12Q1/68 ,  A61K38/03 ,  C07K14/00 ,  C12P19/34 ,  G16B5/00 ,  G16B15/30

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

公开(公告)号：US20210183465A1

公开(公告)日：2021-06-17

申请号：US17028377

申请日：2020-09-22

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: G16B5/00 ,  A61K38/03 ,  C07K14/00 ,  G16B15/30

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

公开(公告)号：US11771755B2

公开(公告)日：2023-10-03

申请号：US16971278

申请日：2019-02-28

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Neil King ,  David Baker ,  Lance Stewart ,  Brooke Fiala ,  Daniel Ellis ,  Lauren Carter ,  Rashmi Ravichandran ,  George Ueda ,  Jorge Fallas ,  Una Nattermann

IPC: A61K39/12 ,  C12N15/86 ,  B82Y5/00 ,  B82Y40/00

CPC classification number: A61K39/12 ,  C12N15/86 ,  B82Y5/00 ,  B82Y40/00 ,  C12N2710/16134 ,  C12N2710/16234 ,  C12N2760/00034

Abstract: Nanostructures and nanostructure-based vaccines that display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens are provided. Some vaccines are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.

公开(公告)号：US10818377B2

公开(公告)日：2020-10-27

申请号：US15813872

申请日：2017-11-15

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: C07K14/00 ,  G16B5/00 ,  A61K38/03 ,  G16B15/30 ,  A61K38/00

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

公开(公告)号：US20190155988A2

公开(公告)日：2019-05-23

申请号：US15813872

申请日：2017-11-15

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: G06F19/12 ,  A61K38/03

CPC classification number: G16B5/00 ,  A61K38/03 ,  C07K14/00 ,  G16B15/30

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.