公开(公告)号：US20230053634A1

公开(公告)日：2023-02-23

申请号：US17810480

申请日：2022-07-01

Applicant: University of Washington ,  ABACUS BIOSCIENCE, INC.

Inventor： Edward A. CLARK ,  Che-Leung LAW ,  Deborah FULLER ,  Michael GALE

IPC: A61K39/29 ,  A61P31/20 ,  C07K16/28

Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpre S1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.

公开(公告)号：US20240123061A1

公开(公告)日：2024-04-18

申请号：US18533676

申请日：2023-12-08

Applicant: University of Washington ,  ABACUS BIOSCIENCE, INC.

Inventor： Edward A. CLARK ,  Deborah L. FULLER ,  Che-Leung LAW ,  Amanda MAK

IPC: A61K39/29 ,  A61K39/00 ,  A61K39/39 ,  C07K16/28 ,  C12N7/00

CPC classification number: A61K39/292 ,  A61K39/001129 ,  A61K39/39 ,  C07K16/2896 ,  C12N7/00 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2319/00 ,  C12N2730/10134

Abstract: Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders.

公开(公告)号：US20220241403A1

公开(公告)日：2022-08-04

申请号：US17721554

申请日：2022-04-15

Applicant: UNIVERSITY OF WASHINGTON ,  ABACUS BIOSCIENCE, INC.

Inventor： Edward A. CLARK ,  Deborah L. FULLER ,  Che-Leung LAW ,  Amanda MAK

IPC: A61K39/29 ,  A61K39/00 ,  A61K39/39 ,  C07K16/28 ,  C12N7/00

Abstract: Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders.

公开(公告)号：US20200306367A1

公开(公告)日：2020-10-01

申请号：US16088386

申请日：2016-11-22

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Edward CLARK ,  Deborah L. FULLER ,  Che-Leung LAW ,  Amanda MAK

IPC: A61K39/29 ,  A61K39/00 ,  C07K16/28 ,  A61K39/39 ,  C12N7/00

Abstract: Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders.

公开(公告)号：US20200345838A1

公开(公告)日：2020-11-05

申请号：US16764950

申请日：2018-11-15

Applicant: University of Washington

Inventor： Edward A. CLARK ,  Che-Leung LAW ,  Deborah FULLER ,  Michael GALE

IPC: A61K39/29 ,  A61P31/20 ,  C07K16/28

Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.