公开(公告)号：US20160146823A1

公开(公告)日：2016-05-26

申请号：US14903012

申请日：2014-07-01

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. CHIU ,  Mengxia ZHAO ,  Wyatt NELSON ,  Perry G. SCHIRO

IPC: G01N33/574 ,  B01L3/00 ,  G01N33/53

Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.

Abstract translation: 本文中提供了用于分析样品中的颗粒的方法和装置。 在一些方面，颗粒可以是分析物，细胞，核酸或蛋白质，并与标签接触，分成等分试样，由排序装置检测并分离。 本文提供的方法和装置可以包括微流体芯片。 在一些方面，所述方法和装置可用于定量样品中的稀有颗粒，例如用于疾病诊断，预后或治疗的癌细胞和其它稀有细胞。

公开(公告)号：US20230023536A1

公开(公告)日：2023-01-26

申请号：US17932687

申请日：2022-09-16

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. CHIU ,  Mengxia ZHAO ,  Wyatt NELSON ,  Perry G. SCHIRO

IPC: G01N33/574 ,  B01L3/00 ,  G01N15/06 ,  G01N15/14 ,  G01N33/49 ,  G01N21/64 ,  G01N33/53

Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.

公开(公告)号：US20200174005A1

公开(公告)日：2020-06-04

申请号：US16702176

申请日：2019-12-03

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. CHIU ,  Mengxia ZHAO ,  Wyatt NELSON ,  Perry G. SCHIRO

IPC: G01N33/574 ,  G01N33/53 ,  B01L3/00 ,  G01N21/64 ,  G01N15/14 ,  G01N15/06 ,  G01N33/49

Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.