公开(公告)号：US20240262845A1

公开(公告)日：2024-08-08

申请号：US18099765

申请日：2023-01-20

申请人： UNIVERSITY OF WYOMING ,  Novartis Institutes for BioMedical Research, Inc.

发明人： Michael T. Taylor ,  Caleb R. Hoopes ,  Akash M. Sarkar ,  Nicholas J. Kuehl ,  Nicole L. Collins ,  Francisco J. Garcia ,  David T. Barkan ,  Glenna E. Meister ,  Taylor R. Bramhall ,  Chien-Hsiang Hsu ,  Michael D. Jones ,  Markus Schirle

IPC分类号： C07D495/04 ,  C07D213/89 ,  C07D401/12 ,  C07K1/113

CPC分类号： C07D495/04 ,  C07D213/89 ,  C07D401/12 ,  C07K1/113

摘要： Embodiments of the present disclosure generally relate to pyridinium salts, compositions thereof, and to methods of use. In an embodiment, a pyridinium salt described herein includes a group that is transferred to a tryptophan residue or moiety of a tryptophan-containing molecule. In another embodiment, a method for modifying a tryptophan residue is provided. The method includes forming a mixture comprising a pyridinium salt and a molecule containing a tryptophan moiety, and exposing the mixture to light to chemically modify the tryptophan moiety of the molecule.

公开(公告)号：US20240262844A1

公开(公告)日：2024-08-08

申请号：US18099760

申请日：2023-01-20

申请人： UNIVERSITY OF WYOMING

发明人： Michael T. Taylor ,  Caleb R. Hoopes ,  Akash M. Sarkar ,  Nicholas J. Kuehl ,  Nicole L. Collins

IPC分类号： C07D495/04 ,  C07D213/89

CPC分类号： C07D495/04 ,  C07D213/89

摘要： Embodiments of the present disclosure generally relate to pyridinium salts, compositions thereof, and to methods of use. In an embodiment, a pyridinium salt described herein includes a group that is transferred to a tryptophan residue or moiety of a tryptophan-containing molecule. In another embodiment, a method for modifying a tryptophan residue is provided. The method includes forming a mixture comprising a pyridinium salt and a molecule containing a tryptophan moiety, and exposing the mixture to light to chemically modify the tryptophan moiety of the molecule.