专利检索 ap:("UNIVERSITY OF WYOMING" OR "Novartis Institutes for BioMedical Research, Inc.") AND inv:"Glenna E. Meister" 第 1 页

1.

发明公开
PYRIDINIUM SALTS, METHODS OF MAKING, AND METHODS OF USE 审中-公开

公开(公告)号：US20240262845A1

公开(公告)日：2024-08-08

申请号：US18099765

申请日：2023-01-20

申请人： UNIVERSITY OF WYOMING , Novartis Institutes for BioMedical Research, Inc.

发明人： Michael T. Taylor , Caleb R. Hoopes , Akash M. Sarkar , Nicholas J. Kuehl , Nicole L. Collins , Francisco J. Garcia , David T. Barkan , Glenna E. Meister , Taylor R. Bramhall , Chien-Hsiang Hsu , Michael D. Jones , Markus Schirle

IPC分类号： C07D495/04 , C07D213/89 , C07D401/12 , C07K1/113

CPC分类号： C07D495/04 , C07D213/89 , C07D401/12 , C07K1/113

摘要： Embodiments of the present disclosure generally relate to pyridinium salts, compositions thereof, and to methods of use. In an embodiment, a pyridinium salt described herein includes a group that is transferred to a tryptophan residue or moiety of a tryptophan-containing molecule. In another embodiment, a method for modifying a tryptophan residue is provided. The method includes forming a mixture comprising a pyridinium salt and a molecule containing a tryptophan moiety, and exposing the mixture to light to chemically modify the tryptophan moiety of the molecule.