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公开(公告)号：US11285219B2
公开(公告)日：2022-03-29
申请号：US16745041
申请日：2020-01-16
发明人： Robert H. Zimmer , Gilles Guichard , Juliette Fremaux , Sebastien Goudreau , Claire Venin , Laura Mauran
IPC分类号： A61K47/59 , A61P3/00 , C07K7/02 , C07K14/605 , A61K38/00
摘要： The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.
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公开(公告)号：US10398750B2
公开(公告)日：2019-09-03
申请号：US14465680
申请日：2014-08-21
IPC分类号： C07K7/02 , A61K38/06 , C08L75/02 , C07K5/02 , A61K38/07 , A61K38/08 , C08G69/10 , C08G69/48 , A61K47/59 , A61K38/00
摘要： The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the invention relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the invention may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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公开(公告)号：US20200155637A1
公开(公告)日：2020-05-21
申请号：US16448910
申请日：2019-06-21
IPC分类号： A61K38/06 , A61K47/59 , C07K5/02 , C07K7/02 , C08G69/10 , C08G69/48 , C08L75/02 , A61K38/07 , A61K38/08
摘要： The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the invention relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the invention may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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4.发明申请MODIFIED PEPTIDES AND THEIR USE FOR TREATING CHRONIC INFLAMMATORY DISEASES 审中-公开改性肽及其用于治疗慢性炎症性疾病的用途公开(公告)号：US20160166636A1
公开(公告)日：2016-06-16
申请号：US14966679
申请日：2015-12-11
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , C07K14/47
摘要： The present invention relates to a peptide, or a salt thereof, comprising or consisting of the amino acid sequence IHMVYSKRSGKPRGYAFIEY, comprising one or more post-translational modifications, for the treatment, prevention or amelioration of a hyper autophagy-related autoimmune disease or disorder.
摘要翻译： 本发明涉及包含一种或多种氨基酸序列IHMVYSKRSGKPRGYAFIEY的肽或其盐，其包含用于治疗，预防或改善超自噬相关自身免疫性疾病或病症的一种或多种翻译后修饰。
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公开(公告)号：US20210308211A1
公开(公告)日：2021-10-07
申请号：US17215089
申请日：2021-03-29
发明人： Robert H. Zimmer , Sylviane Muller
摘要： The present disclosure relates to methods of treating, preventing, or ameliorating at least one symptom of a viral infection or virus-induced immunopathology in a subject in need thereof, as well as methods of modulating the immune response in a subject having a viral infection. The methods include: administering an effective amount of a pharmaceutical composition that includes an effective amount of a peptide having the amino acid sequence as set forth in SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, a salt form thereof, or combination thereof; and at least one pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US20190352341A1
公开(公告)日：2019-11-21
申请号：US16400996
申请日：2019-05-01
发明人： Robert H. Zimmer , Fanny Valleix , Sylviane Muller
IPC分类号： C07K9/00 , C07K14/47 , A61K31/519 , A61P37/06 , G01N33/564 , G01N33/68
摘要： The present invention relates to modified peptides, and their use for treating a lupus-related auto-immune or inflammatory disorder, e.g., systemic lupus erythematosus (SLE or “lupus”).
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公开(公告)号：US10213482B2
公开(公告)日：2019-02-26
申请号：US14966679
申请日：2015-12-11
摘要： The present invention relates to a peptide, or a salt thereof, comprising or consisting of the amino acid sequence IHMVYSKRSGKPRGYAFIEY, comprising one or more post-translational modifications, for the treatment, prevention or amelioration of a hyper autophagy-related autoimmune disease or disorder.
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公开(公告)号：US11267861B2
公开(公告)日：2022-03-08
申请号：US15491929
申请日：2017-04-19
申请人： UREKA SARL
发明人： Robert H. Zimmer , Sebastien Goudreau , Gilles Guichard , Juliette Fremaux , Claire Venin , Laura Mauran
摘要： The present description provides compositions and methods for producing therapeutic compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the present disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the present disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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公开(公告)号：US20190002519A1
公开(公告)日：2019-01-03
申请号：US16023901
申请日：2018-06-29
申请人： UREKA SARL
IPC分类号： C07K14/605 , A61K47/64 , A61P3/08
摘要： The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide or peptidomimetic, wherein the biological property is selected from the group consisting of therapeutic index, stability, solubility, toxicity, adsorption, and pre-systemic metabolism. The pro-drug peptide comprising the following structure: Z-pep, wherein: pep is the parent peptide or peptidomimetic; Z is a sequence of n amino acids, Z is cleaved in vivo releasing pep; n≥2 amino acids. The present disclosure also relates to methods of making and using the pro-drug peptide of the present disclosure. For example, the present disclosure describes a pro-drug peptide that may be used to prevent, treat, or ameliorate at least one symptom of hypoglycemia or a hypoglycemia-related disease or disorder.
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公开(公告)号：US20170298112A1
公开(公告)日：2017-10-19
申请号：US15491929
申请日：2017-04-19
申请人： UREKA SARL
发明人： Robert H. Zimmer , Sebastien Goudreau , Gilles Guichard , Juliette Fremaux , Claire Venin , Laura Mauran
IPC分类号： C07K14/605 , G01N33/74 , A61K38/00
摘要： The present description provides compositions and methods for producing therapeutic compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the present disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the present disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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