公开(公告)号：US20080255068A1

公开(公告)日：2008-10-16

申请号：US11793482

申请日：2005-12-15

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

IPC分类号： A61K31/695 ,  A61K31/47 ,  A61P3/04 ,  A61P25/28 ,  C07D215/20

CPC分类号： C07D215/20

摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

摘要翻译： 本申请涉及一种新的四氢喹啉衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途，特别是作为胆固醇酯的抑制剂 转运蛋白（CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。

公开(公告)号：US08039629B2

公开(公告)日：2011-10-18

申请号：US11793482

申请日：2005-12-15

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

IPC分类号： C07D215/38

摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

公开(公告)号：US08124775B2

公开(公告)日：2012-02-28

申请号：US11793482

申请日：2005-12-15

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

IPC分类号： C07D215/38

CPC分类号： C07D215/20

摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

摘要翻译： 本申请涉及一种新的四氢喹啉衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途，特别是作为胆固醇酯的抑制剂 转运蛋白（CETP）用于治疗和/或预防心血管疾病，特别是下皮脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。

公开(公告)号：US20080194609A1

公开(公告)日：2008-08-14

申请号：US11793483

申请日：2005-12-10

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Martina Wuttke ,  Alexandros Vakalopoulos ,  Olaf Weber

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Martina Wuttke ,  Alexandros Vakalopoulos ,  Olaf Weber

IPC分类号： A61K31/47 ,  C07D215/20 ,  A61P1/00 ,  A61P3/00

CPC分类号： C07D215/20

摘要： The present application relates to novel tetrahydroquinoline derivatives, to a process for their preparation, to their use on their own or in combination for treating and/or preventing diseases and to their use for preparing medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinemias, dyslipidemias, hypertriglyceridemias, hyperlipidemias, hypercholesterolemias and arteriosclerosis.

摘要翻译： 本申请涉及新四氢喹啉衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备药物的用途，特别是作为胆固醇酯转移蛋白的抑制剂 （CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。

公开(公告)号：US08227511B2

公开(公告)日：2012-07-24

申请号：US12225211

申请日：2007-03-07

申请人： Carsten Schmeck ,  Hilmar Bischoff ,  Volkhart Li ,  Klemens Lustig ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber

发明人： Carsten Schmeck ,  Hilmar Bischoff ,  Volkhart Li ,  Klemens Lustig ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber

IPC分类号： A61K31/352 ,  C07D311/04 ,  C07D311/96

CPC分类号： C07D311/22 ,  C07D311/96

摘要： The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

摘要翻译： 本发明涉及取代的苯并二氢吡喃衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。

公开(公告)号：US20090306197A1

公开(公告)日：2009-12-10

申请号：US12225211

申请日：2007-03-07

申请人： Carsten Schmeck ,  Hilmar Bischoff ,  Volkhart Li ,  Klemens Lustig ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber

发明人： Carsten Schmeck ,  Hilmar Bischoff ,  Volkhart Li ,  Klemens Lustig ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber

IPC分类号： A61K31/352 ,  C07D311/04 ,  C07D311/96 ,  A61P9/10

CPC分类号： C07D311/22 ,  C07D311/96

摘要： The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

摘要翻译： 本发明涉及取代的苯并二氢吡喃衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。

公开(公告)号：US20060247303A1

公开(公告)日：2006-11-02

申请号：US10531881

申请日：2003-10-21

申请人： Hilmar Bischoff ,  Frank-Thorsten Hafner ,  Carsten Schmeck ,  Joachim Telser ,  Alexandros Vakalopoulos ,  Gabriele Wirtz ,  Marcus Bauser ,  David Bruckner ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Frank-Thorsten Hafner ,  Carsten Schmeck ,  Joachim Telser ,  Alexandros Vakalopoulos ,  Gabriele Wirtz ,  Marcus Bauser ,  David Bruckner ,  Martina Wuttke

IPC分类号： A61K31/365 ,  C07D321/02

CPC分类号： A61K31/365 ,  C07D321/12

摘要： The present invention relates to substituted 7H-dibenzo[b,g][1,5]dioxocin-5-one-derivatives, to processes for their preparation and to their use in medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemia, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias and arteriosclerosis.

摘要翻译： 本发明涉及取代的7H-二苯并[b，g] [1,5]二氧环辛-5-酮衍生物，其制备方法及其在药物中的用途，特别是胆固醇酯转移蛋白的抑制剂 CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症和动脉硬化。

公开(公告)号：US07192971B2

公开(公告)日：2007-03-20

申请号：US11257931

申请日：2005-10-25

申请人： Jürgen Stoltefuss ,  Michael Lörges ,  Gunter Schmidt ,  Arndt Brandes ,  Carsten Schmeck ,  Klaus-Dieter Bremm ,  Hilmar Bischoff ,  Delf Schmidt

发明人： Jürgen Stoltefuss ,  Michael Lörges ,  Gunter Schmidt ,  Arndt Brandes ,  Carsten Schmeck ,  Klaus-Dieter Bremm ,  Hilmar Bischoff ,  Delf Schmidt

IPC分类号： A61K31/4709 ,  C07D401/04

CPC分类号： C07D401/04 ,  C07D215/20 ,  C07D409/04

摘要： Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.

摘要翻译： 异四氢喹啉可以通过将相应取代的杂四氢喹啉醛与所需的取代基缩合或通过还原相应的酮取代的杂四氢喹啉来制备，然后通过常规方法引入所需的取代基。 杂四氢喹啉适合用作药物中的活性化合物，特别是用于治疗动物硬化和血脂异常的药物。

公开(公告)号：US5932587A

公开(公告)日：1999-08-03

申请号：US883673

申请日：1997-06-27

申请人： Carsten Schmeck ,  Matthias Muller-Gliemann ,  Gunter Schmidt ,  Arndt Brandes ,  Rolf Angerbauer ,  Michael Logers ,  Klaus-Dieter Bremm ,  Hilmar Bischoff ,  Delf Schmidt ,  Joachim Schuhmacher

发明人： Carsten Schmeck ,  Matthias Muller-Gliemann ,  Gunter Schmidt ,  Arndt Brandes ,  Rolf Angerbauer ,  Michael Logers ,  Klaus-Dieter Bremm ,  Hilmar Bischoff ,  Delf Schmidt ,  Joachim Schuhmacher

IPC分类号： C07D491/044 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/55 ,  A61P3/06 ,  A61P9/10 ,  C07C229/14 ,  C07D211/86 ,  C07D211/90 ,  C07D213/80 ,  C07D401/04 ,  C07D471/04 ,  C07D491/04 ,  C07D491/20 ,  C07D493/14 ,  C07D495/04 ,  C07F7/18

CPC分类号： C07D213/80 ,  C07C229/14 ,  C07D211/86 ,  C07D211/90 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07F7/1856

摘要： The heterocyclic-fused pyridines are prepared by reaction of the corresponding heterocyclic-fused pyridine aldehydes with appropriately substituted Grignard or Wittig reagents. The heterocyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of dislipidaemia and arteriosclerosis.

摘要翻译： 杂环稠合的吡啶通过相应的杂环稠合吡啶醛与适当取代的格利雅或维蒂希试剂的反应来制备。 杂环稠合的吡啶适合作为药物中的活性化合物，特别是用于治疗血脂异常和动脉硬化的药物。

公开(公告)号：US20060069112A1

公开(公告)日：2006-03-30

申请号：US11257931

申请日：2005-10-25

申请人： Jürgen Stoltefuß ,  Michael Lörges ,  Gunter Schmidt ,  Arndt Brandes ,  Carsten Schmeck ,  Klaus-Dieter Bremm ,  Hilmar Bischoff ,  Delf Schmidt

发明人： Jürgen Stoltefuß ,  Michael Lörges ,  Gunter Schmidt ,  Arndt Brandes ,  Carsten Schmeck ,  Klaus-Dieter Bremm ,  Hilmar Bischoff ,  Delf Schmidt

IPC分类号： A61K31/4747 ,  A61K31/4709 ,  C07D405/02

CPC分类号： C07D401/04 ,  C07D215/20 ,  C07D409/04

摘要： Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.