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公开(公告)号：US07052452B2
公开(公告)日：2006-05-30
申请号：US10183790
申请日：2002-06-27
申请人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
发明人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A medical system is provided for assessing urinary function. The system includes a control device and at least one test module capable of being removably coupled to the control device such that, when coupled, the system is capable of performing a test to assess urinary function. The control device may include a processor and memory having stored therein a plurality of software subroutine, at least one of which directs a test to assess urinary function. The test module may include a module identification device, and the control device selects the software subroutine based upon information obtained from the module identification device. The test module may further include a tubing assembly forming a first fluid conduit between a first fluid inlet and a first fluid outlet and an insert member dimensioned for at least partial insertion into a patient's urinary tract and coupled to the first fluid outlet so that fluid infused through the first fluid conduit flows through the insert member.
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公开(公告)号：US06997884B2
公开(公告)日：2006-02-14
申请号：US10183295
申请日：2002-06-27
申请人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
发明人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
IPC分类号： A61B5/00
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A test module is provided for coupling with a control device to form a portable system for assessing urinary function. The test module includes a test module housing, at least one coupling element for removably coupling the test module to the control device, a tubing assembly located at least partially within the test module housing, and a pressure interface in fluid communication with at least a portion of the tubing assembly. When the test module is coupled to the control device, the pressure interface is positioned relative to a pressure sensor in the control device so as to transmit pressure data thereto. The tubing assembly may also couple with a pump device in the control device so as to enable the pump device to pump fluid through the tubing assembly.
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公开(公告)号：US07255673B2
公开(公告)日：2007-08-14
申请号：US10183656
申请日：2002-06-27
申请人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
发明人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A method is provided for assessing urinary function including removably coupling a first test module to a portable control device, selecting from a plurality of different tests a first test to assess urinary function, the selection being made based on first module identification information obtained by the control device from the test module, and performing the first test. The method may also include one or more of the steps of inserting an insert member coupled to the first test module at least partially into a patient's urinary tract, infusing fluid through the insert member into the urinary tract, and measuring pressure within the urinary tract as fluid is infused therein. The method may further include uncoupling the first test module from the portable control device, coupling a second test module to the portable control device, selecting a second test to assess urinary function based on second module identification information obtained by the control device from the second test module, and performing the second test.
摘要翻译： 提供了一种用于评估尿功能的方法，包括将第一测试模块可移除地耦合到便携式控制设备，从多个不同测试中选择第一测试来评估尿功能，所述选择是基于通过控制获得的第一模块识别信息 设备，并执行第一次测试。 该方法还可以包括一个或多个步骤：将连接到第一测试模块的插入构件至少部分地插入到患者的尿道中，将流体通过插入构件输入尿道，并且测量尿道内的压力作为 流体注入其中。 该方法还可以包括将第一测试模块与便携式控制设备解耦，将第二测试模块耦合到便携式控制设备，基于由第二测试由控制设备获得的第二模块识别信息，选择第二测试来评估尿功能 模块，并执行第二个测试。
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公开(公告)号：US06916283B2
公开(公告)日：2005-07-12
申请号：US10183082
申请日：2002-06-27
申请人： Michael R. Tracey , Martin Nohilly
发明人： Michael R. Tracey , Martin Nohilly
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A system and method for assessing urinary function is provided. The system includes a processor, a tubing assembly forming a first fluid conduit between a first fluid inlet and a first fluid outlet, and an insert member having a channel therethrough and coupled to the first fluid outlet so that fluid flowing through the first fluid conduit may flow through the insert member. The insert member is dimensioned for at least partial insertion into a patient's urethral canal distal of the patient's urethral sphincter, and dimensioned so that, when inserted, it substantially blocks fluid flow into or out of the urethral canal other than through the insert member channel. The system further includes a fluid delivery device electrically coupled to and controlled by the processor, and coupled to the first fluid conduit for pumping fluid therethrough, and a pressure detection system for detecting pressure within the urethral canal distal of the urethral sphincter and providing information correlating to the detected pressure to the processor. The method includes coupling the test module to the control device, inserting the insert member into a patient, infusing fluid through the insert member until the urethral sphincter opens, and measuring pressure within the urethral canal as fluid is infused therein. Also provided is a test module for coupling to a control device to form a system for assessing urinary function.
摘要翻译： 提供了一种评估尿功能的系统和方法。 该系统包括处理器，在第一流体入口和第一流体出口之间形成第一流体导管的管道组件以及具有穿过其中的通道并与第一流体出口连接的插入件，使得流过第一流体导管的流体可以 流过插入构件。 该插入构件的尺寸设计成至少部分地插入患者的尿道括约肌的远端的患者的尿道管内，其尺寸使得当插入时，其基本上阻止流入或流出尿道的流体，而不是通过插入构件通道。 该系统还包括电耦合到处理器并由处理器控制的流体输送装置，并且耦合到用于泵送流体的第一流体导管，以及用于检测尿道括约肌远端尿道内的压力并提供与尿道括约肌相关的信息的压力检测系统 到检测到的压力到处理器。 该方法包括将测试模块耦合到控制装置，将插入构件插入患者体内，通过插入构件输注流体，直到尿道括约肌打开，并测量流体在尿道口内的压力。 还提供了用于耦合到控制装置以形成用于评估尿功能的系统的测试模块。
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公开(公告)号：US06896650B2
公开(公告)日：2005-05-24
申请号：US10183698
申请日：2002-06-27
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： An insertion device is provided for use in assessing urinary function. The insert device includes an insert member for at least partial insertion into a patient's urethral canal having a length such that it is positioned distal of the urethral sphincter, and having an outer surface at least a portion of which is configured to engage the inner wall of the urethra to substantially prevent fluid flow therebetween. The insert member has a channel therethrough through which fluid from a fluid source can be introduced into the urethral canal. Also provided is a device for introducing fluid into a patient's urethral canal including a hand-sized casing having a fluid conduit therein between a fluid inlet and a fluid source assembly. The device further includes an activation device movable between a first position wherein it does not obstruct the fluid conduit and a second position wherein it does obstruct the fluid conduit. An insert member is coupled to a distal end of the hand-sized casing and has a channel therethrough between a fluid inlet and a fluid outlet, and is dimensioned for at least partial insertion into the patient's urethral canal distal of the urethral sphincter. The insert member channel is in fluid communication with the fluid conduit.
摘要翻译： 提供插入装置用于评估尿功能。 插入装置包括用于至少部分插入到患者的尿道管中的插入构件，其具有使得其位于尿道括约肌远端的长度，并且具有外表面，其外表面的至少一部分被配置为接合尿道括约肌的内壁 尿道基本上防止其间的流体流动。 插入构件具有通道，通过该通道可将来自流体源的流体引入尿道。 还提供了一种用于将流体引入到患者的尿道中的装置，其包括在流体入口和流体源组件之间具有流体导管的手动尺寸的壳体。 该装置还包括可在第一位置和第二位置之间移动的致动装置，其中第一位置不阻塞流体导管，而第二位置阻止流体导管。 插入构件联接到手大小的壳体的远端，并且在流体入口和流体出口之间具有穿过其的通道，并且其尺寸被设计成至少部分地插入到尿道括约肌远端的患者的尿道中。 插入构件通道与流体导管流体连通。
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公开(公告)号：US07979137B2
公开(公告)日：2011-07-12
申请号：US11146522
申请日：2005-06-07
IPC分类号： A61N1/40
CPC分类号： A61N1/36007 , A61B5/20 , A61B5/202 , A61B5/205 , A61B5/6874 , A61B2562/028 , A61N1/0492 , A61N1/0514 , A61N1/0521 , A61N1/36017 , A61N1/36021 , G06F19/00
摘要： A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.
摘要翻译： 一种用于刺激神经的系统和方法，其中所述系统包括适于产生具有能够刺激哺乳动物的预定神经的频率的第一波形的第一波形发生器，适于生成具有频率能力的载波波形的第二波形发生器 通过哺乳动物的组织的调制装置，电耦合到第一和第二波形发生器并适于调制第一和载波波形以产生调制波形的调制装置，以及电耦合到调制装置并基本上邻近皮肤定位的电极 并且适于将调制波形应用于该哺乳动物。
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公开(公告)号：US20100249677A1
公开(公告)日：2010-09-30
申请号：US12661949
申请日：2010-03-26
IPC分类号： A61H1/00
CPC分类号： A61N1/36014 , A61B5/6874 , A61B2562/028 , A61H23/0245 , A61H2201/5005 , A61N1/32 , A61N1/36007 , A61N1/36017 , A61N1/3787
摘要： A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.
摘要翻译： 一种使用包括由电源供电的外部非植入式发送装置的刺激装置来刺激诸如神经的预定身体部位并产生电波形信号的方法。 表面电极经常地施加所生成的电波形信号。 可植入式压电元件接收经过生成的施加的电波形信号，从而导致机械变形，导致可植入式压电元件的机械振动足以刺激预定的身体部位。 电波形信号可以是高频连续波形或高频突发分组。
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公开(公告)号：US07252631B2
公开(公告)日：2007-08-07
申请号：US10674452
申请日：2003-09-30
申请人： Michael R. Tracey
发明人： Michael R. Tracey
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A method is provided for diagnosing detrusor instability. The method includes using an insert member having a channel therethrough positioned distal of the urethral sphincter, creating a substantially fluid tight seal to substantially block fluid flow into or out of the urethral canal other than through the channel, infusing fluid from a fluid source through the channel in the insert member and into the urethral canal at a location distal of the urethral sphincter, and measuring a pressure within the urethral canal at a location distal of the urethral sphincter as the fluid is being infused therein. The infusing step further involves infusing fluid until the urethral sphincter opens, and thereafter until at least one detrusor contraction occurs.
摘要翻译： 提供了一种用于诊断逼尿肌不稳定性的方法。 该方法包括使用具有穿过其定位在尿道括约肌远端的通道的插入构件，产生基本上流体密封的密封，以基本阻止流体流入或流出尿道，而不是通过通道，将来自流体源的流体通过 通道在尿道括约肌远端的位置处进入尿道管，并且当尿液括约肌中注入流体时，在尿道括约肌远端位置测量尿道内的压力。 输注步骤还包括输注流体直到尿道括约肌打开，此后直到发生至少一次逼尿肌收缩。
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公开(公告)号：US20070156012A1
公开(公告)日：2007-07-05
申请号：US11321659
申请日：2005-12-29
申请人： Michael R. Tracey , Steve Bell , Bryan Knodel
发明人： Michael R. Tracey , Steve Bell , Bryan Knodel
IPC分类号： A61F2/02
CPC分类号： A61F2/0045 , A61B17/0625 , A61B2017/00805 , A61F2/0036
摘要： A suburethral implant for treating stress urinary incontinence (SUI) includes an elongated plate-like member which is slightly curved in transverse cross-section, and a pair of spaced apart arms having hooked ends or barbs which extend from the plate-like member. A device for deploying the suburethral implant for treating SUI includes a vaginal probe for insertion in the vaginal canal of a patient, and a urethra locator probe for the simultaneous insertion in the urethra of a patient. The urethra probe is spaced apart from and overlies the vaginal probe. The vaginal probe includes a wall in which is formed an exit port. A suburethral implant introducer assembly is extendable and retractable through the exit port on the vaginal probe. The introducer assembly has a distal end on which is removably mounted a suburethral implant. The introducer assembly is extendable through the exit port to pierce the vaginal canal wall of the patient in order to position the suburethral implant in proximity to the patient's urethra. The hooked ends or barbs on the arms of the suburethral implant engage the tissue surrounding the patient's urethra and are affixed thereto during deployment of the implant. The introducer assembly is then retracted into the vaginal probe, whereby the implant is released from the introducer assembly and remains affixed to tissue in proximity to the patient's urethra.
摘要翻译： 用于治疗压力性尿失禁的尿道植入物（SUI）包括在横截面上略微弯曲的细长板状构件，以及一对间隔开的臂，其具有从板状构件延伸的钩端或倒钩。 用于部署用于治疗SUI的尿道植入物的装置包括用于插入患者阴道内的阴道探针和用于同时插入患者尿道的尿道定位器探针。 尿道探针与阴道探针间隔开并覆盖阴道探针。 阴道探针包括形成有出口的壁。 尿道植入物导引器组件可以通过阴道探针上的出口延伸和缩回。 导引器组件具有远端，其上可移除地安装有尿道植入物。 导引器组件可通过出口延伸以刺穿患者的阴道管壁，以将尿道植入物定位在患者的尿道附近。 尿道植入物的手臂上的钩状端或倒钩与患者尿道周围的组织接合，并在植入物展开过程中固定在其上。 导引器组件然后缩回到阴道探针中，由此植入物从导引器组件释放并且保持附着于患者尿道附近的组织。
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10.发明授权公开(公告)号：US09139542B2
公开(公告)日：2015-09-22
申请号：US14198975
申请日：2014-03-06
申请人： Weijiang Zhang , Michael R. Tracey , Junning Lee
发明人： Weijiang Zhang , Michael R. Tracey , Junning Lee
IPC分类号： C07D277/40 , C07D277/593
CPC分类号： C07D277/40 , C07D277/593
摘要： The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2 -amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.
摘要翻译： 本发明涉及（2Z）-2-（2-氨基-5-氯噻唑-4-基）-2-（3-N-叔丁氧基羰基氨基丙氧基亚氨基）乙酸的三乙胺盐的结晶形式。 本发明还涉及制备结晶形式的方法和中间体。 结晶形式可用作制备交联糖肽 - 头孢菌素抗生素的中间体。
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