利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.02 秒)

    Non-natural galanin receptor ligands
    2.
    发明授权
    Non-natural galanin receptor ligands 失效
    非天然甘丙肽受体配体

    公开(公告)号：US06747060B2

    公开(公告)日：2004-06-08

    申请号：US10155376

    申请日：2002-05-24

    申请人： Kulliki Saar ,  Tamas Bartfai ,  Ulo Langel ,  Gerd Hallnemo ,  Sven Hellberg

    发明人： Kulliki Saar ,  Tamas Bartfai ,  Ulo Langel ,  Gerd Hallnemo ,  Sven Hellberg

    IPC分类号： A61K3135

    CPC分类号： C07K5/06078 ,  A61K38/00

    摘要： Compounds which are non-natural galanin receptor ligands are disclosed. The ligands are of small size, have agonist or antagonist galanin activity and may cross the blood-brain barrier to displace galanin from galanin receptors. The ligands are useful as medicaments for treatment of convulsions (e.g. in epilepsy), diseases and disorders related to endocrinology (e.g., growth hormone, insulin or prolactin release), tumors expressing galanin receptors, feeding disorders pain, allodynia, psychiatric disorders such as depression (involving e.g., noradrenaline or serotonin), cognitive disorders (e.g. Alzeimer's disease), and the like.

    摘要翻译： 公开了非天然甘氨酸受体配体的化合物。 配体具有小尺寸，具有激动剂或拮抗剂甘丙肽活性，并且可以穿过血脑屏障以从甘丙肽受体取代甘丙肽。 配体可用作治疗惊厥（例如癫痫），与内分泌学（例如生长激素，胰岛素或催乳素释放）相关的疾病和病症的药物，表达甘丙肽受体的肿瘤，进食障碍性疼痛，异常性疼痛，抑郁症等精神疾病 （例如，去甲肾上腺素或5-羟色胺），认知障碍（例如Alzeimer病）等。

    Bordetella toxin peptides and vaccines
    4.
    发明授权
    Bordetella toxin peptides and vaccines 失效
    BORDETELLA TOXIN PEPTIDES和VACCINES

    公开(公告)号：US5225193A

    公开(公告)日：1993-07-06

    申请号：US346837

    申请日：1989-05-24

    申请人： Tamas Bartfai

    发明人： Tamas Bartfai

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/10 ,  A61P37/00 ,  C07K7/08 ,  C07K14/235 ,  G01N33/569

    CPC分类号： C07K14/235 ,  A61K39/00 ,  Y10S530/825

    摘要： The following new polypeptides are described: (a) H-X.sup.1 -Asp-Asp-Pro-Pro-Ala-Thr-Val-Tyr-Arg-Tyr-Asp-Ser-Arg-Pro-Pro-Glu-Asp-X.sup.2 -Y, (b) H-X.sup.1 -Ser-Glu-Tyr-Leu-Ala-His-Arg-Arg-Ile-Pro-Pro-Glu-Asn-Ile-Arg-Arg-Val-Thr-Arg-Val-X.sup.2 -Y, (c) H-X.sup.1 -Ala-Phe-Val-Ser-Thr-Ser-Ser-Ser-Arg-Arg-Tyr-Thr-Glu-Val-Tyr-X.sup.2 -Y, (d) H-X.sup.1 -Gly-Ile-Thr-Gly-Glu-Thr-Thr-Thr-Thr-Glu-Tyr-Ser-Asn-Ala-Arg-Tyr-Val-X.sup.2 -Y, and (e) H-X.sup.1 -Leu-Glu-His-Arg-Met-Gln-Glu-Ala-Val-Glu-Ala-Glu-Arg-Ala-Gly-Arg-Gly-Thr-Gly-His-Phe-Ile-X.sup.2 -Y, in which X.sup.1 and X.sup.2 each represents an optional coupling-facilitating amino acid residue, and Y represents --OH or --NH.sub.2. Additionally, there is described an artificial pertussis toxin antigen, which mainly consists of at least one peptide sequence reacting with antibodies induced by the native pertussis toxin selected from the above polypeptides (a) to (e) and parts thereof. The above described artificial pertussis toxin antigen is included as a diagnostic antigen in a diagnostic immunoassay kit for the determination of antibodies induced by the native pertussis toxin in a sample of biological fluid, and as an immunizing component in a vaccine composition against whooping cough, respectively. Furthermore there is described an intradermal skin test composition comprising the above described artificial pertussis toxin antigen.

    Apparatus for determining and/or monitoring the level of a medium
    7.
    发明授权
    Apparatus for determining and/or monitoring the level of a medium 有权
    用于确定和/或监测介质水平的装置

    公开(公告)号：US08040274B2

    公开(公告)日：2011-10-18

    申请号：US12308937

    申请日：2007-06-14

    申请人： Armin Wendler ,  Qi Chen ,  Tamas Bartfai

    发明人： Armin Wendler ,  Qi Chen ,  Tamas Bartfai

    IPC分类号： G01S13/08

    CPC分类号： G01F23/284

    摘要： An apparatus for ascertaining and/or monitoring fill level of a medium in a container. The apparatus includes an antenna, which transmits and receives high frequency signals in a predetermined oscillatory mode in a bounded space in a predetermined radiation direction, wherein, in front of the antenna in the radiation direction, an antenna protection element of a material transmissive for the high frequency signals is provided, and wherein a control/evaluation unit is provided, which evaluates the received high frequency signals and ascertains the fill level.

    摘要翻译： 一种用于确定和/或监测容器中的介质的填充水平的装置。 该装置包括天线，其以预定的辐射方向在有界空间中以预定的振荡模式发送和接收高频信号，其中在辐射方向上的天线前面，透射天线的材料的天线保护元件 提供高频信号，并且其中提供控制/评估单元，其评估所接收的高频信号并确定填充水平。

    Apparatus for determining and/or monitoring the level of a medium
    8.
    发明申请
    Apparatus for determining and/or monitoring the level of a medium 有权
    用于确定和/或监测介质水平的装置

    公开(公告)号：US20100090883A1

    公开(公告)日：2010-04-15

    申请号：US12308937

    申请日：2007-06-14

    申请人： Qi Chen ,  Tamas Bartfai ,  Armin Wendler

    发明人： Qi Chen ,  Tamas Bartfai ,  Armin Wendler

    IPC分类号： G01F23/284

    CPC分类号： G01F23/284

    摘要： An apparatus for ascertaining and/or monitoring fill level of a medium in a container. The apparatus includes an antenna, which transmits and receives high frequency signals in a predetermined oscillatory mode in a bounded space in a predetermined radiation direction, wherein, in front of the antenna in the radiation direction, an antenna protection element of a material transmissive for the high frequency signals is provided, and wherein a control/evaluation unit is provided, which evaluates the received high frequency signals and ascertains the fill level.

    摘要翻译： 一种用于确定和/或监测容器中的介质的填充水平的装置。 该装置包括天线，其以预定的辐射方向在有界空间中以预定的振荡模式发送和接收高频信号，其中在辐射方向上的天线前面，透射天线的材料的天线保护元件 提供高频信号，并且其中提供控制/评估单元，其评估所接收的高频信号并确定填充水平。

    Polypeptide compound which binds to glyco-conjugates and to artificial pertussis toxin antigen
    9.
    发明授权
    Polypeptide compound which binds to glyco-conjugates and to artificial pertussis toxin antigen 失效
    结合糖缀合物和人造百日咳毒素抗原的多肽化合物

    公开(公告)号：US5283321A

    公开(公告)日：1994-02-01

    申请号：US375004

    申请日：1989-07-18

    申请人： Tamas Bartfai

    发明人： Tamas Bartfai

    IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/10 ,  A61K49/00 ,  C07K7/08 ,  C07K14/00 ,  C07K14/235 ,  C07K14/76 ,  C07K19/00 ,  G01N33/569 ,  C07K7/00

    CPC分类号： C07K14/235 ,  A61K49/00 ,  A61K39/00

    摘要： A polypeptide of the formulaH--X.sup.1 --Gln--Thr--Art--Ala--Asn--Pro--Asn--Pro--Tyr--Thr----Ser--Arg--Arg--Ser--Val--Ala--Ser--X.sup.2 --Yin which X.sup.1 and X.sup.2 each represents an optional coupling-facilitating amino acid residue, and Y represents --OH or --NH.sub.2, and an artificial compound in free or carrier-associated form with the capability of binding to glyco-conjugates, especially immunoglobulins, which compound is chosen from the group consisting of said peptide and functional analogues and functional derivatives thereof, are disclosed. Additionally, there is described an artificial pertussis toxin antigen, which mainly consists of at least one peptide sequence reacting with antibodies induced by the native pertussis toxin selected from the above polypeptide and parts thereof. The above described artificial pertussis toxin antigen is included as a diagnostic antigen in a diagnostic immunoassay kit for the determination of antibodies induced by the native pertussis toxin in a sample of biological fluid, and as an immunizing component in a vaccine composition against whooping cough, respectively. Furthermore, there is described an intradermal skin test composition comprising the above described artificial pertussis toxin antigen.

    摘要翻译： PCT No.PCT / SE87 / 00619 Sec。 371日期：1989年7月18日 102（e）日期1989年7月18日PCT 1987年12月21日PCT公布。 出版物WO88 / 04665 日期：1988年6月30日。式H-X1-Gln-Thr-Art-Ala-Asn-Pro-Asn-Pro-Tyr-Thr-Ser-Arg-Arg-Ser-Val-Ala-Ser -X2-Y，其中X1和X2各自表示任选的偶合促进氨基酸残基，Y表示-OH或-NH 2，以及具有结合糖缀合物的能力的游离或载体相关形式的人造化合物， 特别是免疫球蛋白，该化合物选自所述肽及其功能类似物及其功能衍生物。 此外，描述了人造百日咳毒素抗原，其主要由与上述多肽及其部分的天然百日咳毒素诱导的抗体反应的至少一个肽序列组成。 将上述人造百日咳毒素抗原作为诊断性抗原包括在用于测定生物流体样品中天然百日咳毒素诱导的抗体的诊断性免疫测定试剂盒中，并分别作为针对百日咳的疫苗组合物中的免疫组分 。 此外，描述了包含上述人造百日咳毒素抗原的皮内皮肤试验组合物。