-
公开(公告)号：US20190105400A1
公开(公告)日：2019-04-11
申请号：US15418180
申请日：2017-01-27
申请人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogoe , Thomas Wegge , Oliver Keil , Joachim Zettler
发明人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogoe , Thomas Wegge , Oliver Keil , Joachim Zettler
摘要： The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
-
公开(公告)号：US09561287B2
公开(公告)日：2017-02-07
申请号：US14238437
申请日：2012-08-10
申请人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogøe , Thomas Wegge , Oliver Keil , Joachim Zettler
发明人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogøe , Thomas Wegge , Oliver Keil , Joachim Zettler
IPC分类号： A61K47/48
CPC分类号： A61K47/48253 , A61K47/60 , A61K47/641 , A61K47/645
摘要： The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
摘要翻译： 本发明涉及包含共价曲前列腺素载体缀合物的前药或其药学上可接受的盐以及包含所述化合物的药物组合物。 这些化合物可以用作药物，特别是可以通过曲前列素治疗的疾病或病症，例如肺动脉高压（PAH）。
-
公开(公告)号：US20140296150A1
公开(公告)日：2014-10-02
申请号：US14238437
申请日：2012-08-10
申请人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogøe , Thomas Wegge , Oliver Keil , Joachim Zettler
发明人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogøe , Thomas Wegge , Oliver Keil , Joachim Zettler
IPC分类号： A61K47/48
CPC分类号： A61K47/48253 , A61K47/60 , A61K47/641 , A61K47/645
摘要： The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
摘要翻译： 本发明涉及包含共价曲前列腺素载体缀合物的前药或其药学上可接受的盐以及包含所述化合物的药物组合物。 这些化合物可以用作药物，特别是可以通过曲前列素治疗的疾病或病症，例如肺动脉高压（PAH）。
-
公开(公告)号：US10729778B2
公开(公告)日：2020-08-04
申请号：US15418180
申请日：2017-01-27
申请人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogøe , Thomas Wegge , Oliver Keil , Joachim Zettler
发明人： Ulrich Hersel , Harald Rau , Torben Lessmann , Nicola Bisek , Guillaume Maitro , Kennett Sprogøe , Thomas Wegge , Oliver Keil , Joachim Zettler
摘要： Prodrugs or a pharmaceutically acceptable salt thereof which comprise a covalent treprostinil carrier conjugate, as well as their pharmaceutical composition, may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
-
公开(公告)号：US20120183616A1
公开(公告)日：2012-07-19
申请号：US13387959
申请日：2010-07-30
申请人： Kennett Sprogoe , Felix Cleemann , Ulrich Hersel , Silvia Kaden-Vagt , Torben Lessmann , Harald Rau , Thomas Wegge
发明人： Kennett Sprogoe , Felix Cleemann , Ulrich Hersel , Silvia Kaden-Vagt , Torben Lessmann , Harald Rau , Thomas Wegge
CPC分类号： A61K9/06 , A61K9/0019 , A61K9/19 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/50 , A61K47/60 , A61K47/69 , Y10T428/13 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising an insulin compound in a concentration that is sufficient to maintain a therapeutically effective level of the insulin compound in blood plasma for at least 3 days characterized by having a pharmacokinetic profile in vivo with substantially no burst of the insulin compound. The present invention further relates to the use of an insulin compound for preparing said pharmaceutical composition as well as a kit of parts comprising said pharmaceutical composition.
摘要翻译： 本发明涉及包含胰岛素化合物的药物组合物，其浓度足以将血浆中的胰岛素化合物的治疗有效水平维持在血浆中至少3天，其特征在于在体内具有药代动力学特征，基本上没有 胰岛素复合物。 本发明还涉及胰岛素化合物用于制备所述药物组合物的用途以及包含所述药物组合物的试剂盒。
-
公开(公告)号：US09265723B2
公开(公告)日：2016-02-23
申请号：US13387959
申请日：2010-07-30
申请人： Kennett Sprogoe , Felix Cleemann , Ulrich Hersel , Silvia Kaden-Vagt , Torben Lessmann , Harald Rau , Thomas Wegge
发明人： Kennett Sprogoe , Felix Cleemann , Ulrich Hersel , Silvia Kaden-Vagt , Torben Lessmann , Harald Rau , Thomas Wegge
CPC分类号： A61K9/06 , A61K9/0019 , A61K9/19 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/50 , A61K47/60 , A61K47/69 , Y10T428/13 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising an insulin compound in a concentration that is sufficient to maintain a therapeutically effective level of the insulin compound in blood plasma for at least 3 days characterized by having a pharmacokinetic profile in vivo with substantially no burst of the insulin compound. The present invention further relates to the use of an insulin compound for preparing said pharmaceutical composition as well as a kit of parts comprising said pharmaceutical composition.
摘要翻译： 本发明涉及包含胰岛素化合物的药物组合物，其浓度足以将血浆中的胰岛素化合物的治疗有效水平维持在血浆中至少3天，其特征在于在体内具有药代动力学特征，基本上没有 胰岛素复合物。 本发明还涉及胰岛素化合物用于制备所述药物组合物的用途以及包含所述药物组合物的试剂盒。
-
公开(公告)号：US09062094B2
公开(公告)日：2015-06-23
申请号：US13574092
申请日：2011-01-21
申请人： Harald Rau , Torben Lessmann
发明人： Harald Rau , Torben Lessmann
CPC分类号： C07K1/13 , A61K47/48215 , A61K47/48338 , A61K47/60 , A61K47/65 , C07K1/1077
摘要： The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aliphatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
摘要翻译： 本发明涉及其前体药物或其药学上可接受的盐，其包含药物接头缀合物DL，其中D是含有脂族胺基团的生物活性部分通过含二肽的接头L与一个或多个聚合物载体缀合。这种载体 连接的前药实现具有治疗有用的半衰期的药物释放。 本发明还涉及包含所述前体药物及其用作药物的药物组合物。
-
公开(公告)号：US20130053301A1
公开(公告)日：2013-02-28
申请号：US13574092
申请日：2011-01-21
申请人： Harald Rau , Torben Lessmann
发明人： Harald Rau , Torben Lessmann
IPC分类号： C07K17/08 , A61K38/05 , A61P25/00 , A61P31/00 , A61M5/31 , A61P37/02 , A61P3/04 , A61P7/02 , A61P3/10 , A61P35/00 , C07D413/14 , A61P37/08
CPC分类号： C07K1/13 , A61K47/48215 , A61K47/48338 , A61K47/60 , A61K47/65 , C07K1/1077
摘要： The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aliphatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
-
公开(公告)号：US09561285B2
公开(公告)日：2017-02-07
申请号：US13574120
申请日：2011-01-21
申请人： Harald Rau , Torben Lessmann
发明人： Harald Rau , Torben Lessmann
IPC分类号： A61K47/48
CPC分类号： A61K47/48215 , A61K47/48338 , A61K47/60 , A61K47/65 , A61K47/6903
摘要： The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
摘要翻译： 本发明涉及其前体药物或其药学上可接受的盐，其包含药物连接物缀合物DL，其中D是含有芳族羟基的生物活性部分，通过含有次氨基甲酸酯的接头L与一个或多个聚合物载体缀合。 载体连接的前药实现具有治疗有用的半衰期的药物释放。 本发明还涉及包含所述前体药物及其用作药物的药物组合物。
-
公开(公告)号：US20130035635A1
公开(公告)日：2013-02-07
申请号：US13574120
申请日：2011-01-21
申请人： Harald Rau , Torben Lessmann
发明人： Harald Rau , Torben Lessmann
IPC分类号： A61K31/27 , A61M5/31 , A61K31/4015 , A61P29/00 , C07C271/52 , C07D207/416
CPC分类号： A61K47/48215 , A61K47/48338 , A61K47/60 , A61K47/65 , A61K47/6903
摘要： The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
摘要翻译： 本发明涉及其前体药物或其药学上可接受的盐，其包含药物连接物缀合物DL，其中D是含有芳族羟基的生物活性部分，通过含有次氨基甲酸酯的接头L与一个或多个聚合物载体缀合。 载体连接的前药实现具有治疗有用的半衰期的药物释放。 本发明还涉及包含所述前体药物及其用作药物的药物组合物。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.041 秒)
