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公开(公告)号：US08389043B2
公开(公告)日：2013-03-05
申请号：US12835420
申请日：2010-07-13
申请人： Ulrich Speck , Bruno Scheller
发明人： Ulrich Speck , Bruno Scheller
CPC分类号： A61L29/08 , A61K9/0019 , A61K9/5094 , A61K31/095 , A61K31/165 , A61K31/337 , A61K45/06 , A61K49/0433 , A61K49/0438 , A61K49/0447 , A61K49/0452 , A61K49/105 , A61K49/106 , A61K49/18 , A61L29/16 , A61L29/18 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
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公开(公告)号：US20100324648A1
公开(公告)日：2010-12-23
申请号：US12675394
申请日：2008-08-26
申请人： Bruno Scheller , Ulrich Speck
发明人： Bruno Scheller , Ulrich Speck
IPC分类号： A61F2/84
CPC分类号： A61M25/10 , A61F2/958 , A61F2250/0067 , A61M2025/105 , A61M2025/1081
摘要： The invention relates to a drug-coated balloon catheter which has a catheter balloon mounted on its distal end and an expansion protection surrounding the same. The invention is characterized in that the catheter balloon is protected from premature expansion even under strong mechanical stress and in that the catheter balloon folds back more easily after dilation.
摘要翻译： 本发明涉及一种药物涂覆的球囊导管，其具有安装在其远端上的导管球囊和围绕其的扩张保护。 本发明的特征在于即使在强力机械应力下也能够保护导管球囊免于过早膨胀，并且导管气囊在扩张后更容易折回。
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公开(公告)号：US20060020243A1
公开(公告)日：2006-01-26
申请号：US10528577
申请日：2003-08-26
申请人： Ulrich Speck , Bruno Scheller
发明人： Ulrich Speck , Bruno Scheller
IPC分类号： A61M29/00
CPC分类号： A61M25/1002 , A61L29/08 , A61L29/085 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/43 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M25/1038 , A61M25/104 , A61M2025/0057 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.
摘要翻译： 为了对患病组织切片或器官部分进行选择性治疗，在压力下与其区域接触的医疗器械的表面涂覆有亲和的基本上不溶于水的药物，其结合到具有良好粘附性的各种组织组分，所述药物具有以下作用： 与其接触后的短时间，而不会对邻近的健康组织产生有害影响。
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公开(公告)号：US08608689B2
公开(公告)日：2013-12-17
申请号：US12671910
申请日：2008-08-01
申请人： Bruno Scheller , Ulrich Speck
发明人： Bruno Scheller , Ulrich Speck
IPC分类号： A61M25/12
CPC分类号： A61M25/1029 , A61L29/08 , A61L29/145 , A61L29/16 , A61L2300/204 , A61L2300/21 , A61L2300/22 , A61L2300/602 , A61L2420/02 , A61L2420/06 , A61M25/0045 , A61M25/10 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , B05D1/26
摘要： This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.
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公开(公告)号：US20100278997A1
公开(公告)日：2010-11-04
申请号：US12835420
申请日：2010-07-13
申请人： Ulrich Speck , Bruno Scheller
发明人： Ulrich Speck , Bruno Scheller
IPC分类号： B05D3/00
CPC分类号： A61L29/08 , A61K9/0019 , A61K9/5094 , A61K31/095 , A61K31/165 , A61K31/337 , A61K45/06 , A61K49/0433 , A61K49/0438 , A61K49/0447 , A61K49/0452 , A61K49/105 , A61K49/106 , A61K49/18 , A61L29/16 , A61L29/18 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
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公开(公告)号：US10532189B2
公开(公告)日：2020-01-14
申请号：US12675394
申请日：2008-08-26
申请人： Bruno Scheller , Ulrich Speck
发明人： Bruno Scheller , Ulrich Speck
摘要： The invention relates to a drug-coated balloon catheter which has a catheter balloon mounted on its distal end and an expansion protection surrounding the same. The invention is characterized in that the catheter balloon is protected from premature expansion even under strong mechanical stress and in that the catheter balloon folds back more easily after dilation.
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公开(公告)号：US09066990B2
公开(公告)日：2015-06-30
申请号：US12835414
申请日：2010-07-13
申请人： Ulrich Speck , Bruno Scheller
发明人： Ulrich Speck , Bruno Scheller
IPC分类号： A61L29/08 , A61K9/00 , A61K9/50 , A61K31/095 , A61K31/165 , A61K31/337 , A61K45/06 , A61K49/04 , A61K49/10 , A61K49/18 , A61L29/16 , A61L29/18 , A61L31/16
CPC分类号： A61L29/08 , A61K9/0019 , A61K9/5094 , A61K31/095 , A61K31/165 , A61K31/337 , A61K45/06 , A61K49/0433 , A61K49/0438 , A61K49/0447 , A61K49/0452 , A61K49/105 , A61K49/106 , A61K49/18 , A61L29/16 , A61L29/18 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
摘要翻译： 本发明涉及预防再狭窄的制剂。 已知的再狭窄预防制剂在血管壁的受影响部分中不能达到足够的活性剂浓度，因为较高剂量引起不期望的副作用。 本发明是一种具有至少一种具有丁醇与水分配比例的抗高血压药物的制剂。 亲脂性活性剂被血管壁快速且足够的量吸收。 该制剂可以是可以通过毛细血管并且可以含有造影剂的液体，使得活性剂在没有任何额外的努力的同时转移到血管壁中，而通常需要的对比度放射照相。 该制剂也可以应用于导管。
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公开(公告)号：US08439868B2
公开(公告)日：2013-05-14
申请号：US12782989
申请日：2010-05-19
申请人： Ulrich Speck , Bruno Scheller
发明人： Ulrich Speck , Bruno Scheller
IPC分类号： A61M29/00
CPC分类号： A61M25/1002 , A61L29/08 , A61L29/085 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/43 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M25/1038 , A61M25/104 , A61M2025/0057 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： The present disclosure relates to balloon catheter medical devices. Some balloon catheter medical devices may include a balloon surface having paclitaxel embedded in a low-molecular weight matrix substance adhered thereto and dried. The dried paclitaxel may be immediately releasable after coming into contact with tissue. Other balloon catheter medical devices may include a balloon surface having a lipophilic proliferation inhibitor, an inflammation inhibitor, or an antioxidant adhered thereto.
摘要翻译： 本发明涉及气囊导管医疗装置。 一些气囊导管医疗装置可以包括具有紫杉醇的球囊表面，紫杉醇嵌入到粘附到其上并干燥的低分子量基质物质中。 干燥的紫杉醇可以在与组织接触后立即释放。 其他球囊导管医疗装置可以包括具有亲脂性增殖抑制剂，炎症抑制剂或附着于其上的抗氧化剂的气囊表面。
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9.发明申请公开(公告)号：US20110238011A1
公开(公告)日：2011-09-29
申请号：US12671910
申请日：2008-08-01
申请人： Bruno Scheller , Ulrich Speck
发明人： Bruno Scheller , Ulrich Speck
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61L29/08 , A61L29/145 , A61L29/16 , A61L2300/204 , A61L2300/21 , A61L2300/22 , A61L2300/602 , A61L2420/02 , A61L2420/06 , A61M25/0045 , A61M25/10 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , B05D1/26
摘要： This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.
摘要翻译： 本发明涉及球囊导管和含有粘附到球囊膜表面的活性物质的制剂的新组合。 此外，本发明涉及用于制造这些气囊导管的涂覆方法以及它们在治疗和预防血管疾病中的用途。
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公开(公告)号：US08257305B2
公开(公告)日：2012-09-04
申请号：US10528577
申请日：2003-08-26
申请人： Ulrich Speck , Bruno Scheller
发明人： Ulrich Speck , Bruno Scheller
IPC分类号： A61M29/00
CPC分类号： A61M25/1002 , A61L29/08 , A61L29/085 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/43 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M25/1038 , A61M25/104 , A61M2025/0057 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.
摘要翻译： 为了对患病组织切片或器官部分进行选择性治疗，在压力下与其区域接触的医疗器械的表面涂覆有亲和的基本上不溶于水的药物，其结合到具有良好粘附性的各种组织组分，所述药物具有以下作用： 与其接触后的短时间，而不会对邻近的健康组织产生有害影响。
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