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13 条记录 (耗时 0.017 秒)

    Triiodinated aminoacetamido isophthalamide x-ray contrast agents
    1.
    发明授权
    Triiodinated aminoacetamido isophthalamide x-ray contrast agents 失效
    三碘代氨基乙酰氨基间苯二胺X射线造影剂

    公开(公告)号：US4283381A

    公开(公告)日：1981-08-11

    申请号：US167597

    申请日：1980-07-11

    申请人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    发明人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    IPC分类号： A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C237/46 ,  C07D209/48 ,  C07C103/183 ,  C07C103/50

    CPC分类号： C07D209/48

    摘要： Compounds of the formula ##STR1## wherein X is alkylene, optionally substituted by hydroxy, methoxy or amino;R.sup.1 is hydrogen or C.sub.1-4 alkyl;R.sup.2 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.3 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.4 is hydrogen, C.sub.1-4 -alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.5 is C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.6 is hydrogen, C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-3 OH groups; andR.sup.7 is C.sub.2-4 -alkyl substituted by 1-3 OH groups,or a salt thereof with an acidare useful as opaquing agents in x-ray contrast media.

    摘要翻译： 式（I）的化合物其中X为亚烷基，任选被羟基，甲氧基或氨基取代; R1是氢或C1-4烷基; R2是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R3是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R4是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R5是被1-3个OH基取代的C2-4-烷基; R6是氢，C1-4烷基或被1-3个OH基取代的C2-4烷基; 并且R 7为被1-3个OH基取代的C 2-4烷基，或其与酸的盐可用作x射线造影剂中的不透明剂。

    X-ray contrast media
    2.
    发明授权
    X-ray contrast media 失效
    X射线造影剂

    公开(公告)号：US4264572A

    公开(公告)日：1981-04-28

    申请号：US99172

    申请日：1979-11-30

    申请人： Erich Klieger ,  Wolfgang Mutzel

    发明人： Erich Klieger ,  Wolfgang Mutzel

    IPC分类号： A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/08 ,  C07C231/12 ,  C07C233/12 ,  C07C237/46 ,  C07C101/48

    CPC分类号： C07C233/12

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted by OH or C.sub.1-2 alkoxy; R.sub.2, R.sub.3 and R.sub.4 are independently each hydrogen or C.sub.1-4 alkyl; Z is --A--NHCH.sub.3 or when R.sub.1 is hydroxy or alkoxy substituted alkyl and/or when R.sub.3 is lower alkyl, Z can also be hydroxy-C.sub.2-5 -alkylamino;R.sub.5 is C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by OH; n is 1, 2 or 3; and A is: ##STR2## wherein R.sub.7 is H or C.sub.1-4 alkyl; R.sub.8 is H, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by OH or C.sub.1-2 alkoxy; or together R.sub.7 and R.sub.8 form a propylene or hydroxypropylene ring; and m is 0 or 1;or an ester thereof with a C.sub.1 -C.sub.4 alkanol or a physiologically acceptable salt thereof with a base, are valuable as X-ray contrast media.

    摘要翻译： 其中R 1是C 1-4烷基，被OH或C 1-2烷氧基取代的C 1-4烷基; R2，R3和R4分别独立地为氢或C1-4烷基; Z是-A-NHCH 3，或当R 1是羟基或烷氧基取代的烷基和/或当R 3是低级烷基时，Z也可以是羟基-C 2-5 - 烷基氨基; R5是C1-4烷基或被OH取代的C1-4烷基; n为1,2或3; A是：其中R 7是H或C 1-4烷基; R8是H，C1-4烷基或被OH或C1-2烷氧基取代的C1-4烷基; 或一起R7和R8形成丙烯或羟基丙烯环; m为0或1; 或其与C 1 -C 4链烷醇或其生理学上可接受的盐的酯与基质作为X射线造影剂是有价值的。

    Novel iodized isophthalamic acid compounds
    4.
    发明授权
    Novel iodized isophthalamic acid compounds 失效
    新型碘化间苯二甲酸化合物

    公开(公告)号：US4132731A

    公开(公告)日：1979-01-02

    申请号：US806383

    申请日：1977-06-14

    申请人： Erich Klieger ,  Ulrich Speck

    发明人： Erich Klieger ,  Ulrich Speck

    IPC分类号： A61K31/195 ,  A61K20060101 ,  A61K49/04 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C237/46 ,  C07C63/12 ,  A61K29/02

    CPC分类号： A61K49/0447

    摘要： Iodized isophthalamic acid compounds of the formula ##STR1## wherein R.sub.1 is straight-chain or branched lower hydroxyalkyl;R.sub.2 is hydroxymethyl or a lower, straight-chain or branched alkyl of at least 2 carbon atoms, which can be interrupted by one or more oxygen atoms, or is ##STR2## wherein Z is a carbon-to-carbon bond or a straight-chain or branched hydrocarbon which can be interrupted by one or more oxygen atoms, or when R.sub.1 is other than --CH.sub.2 --CH.sub.2 --OH, is methyl; and the salts thereof with physiologically acceptable inorganic or organic bases, are x-ray contrast agents.

    摘要翻译： 其中R1是直链或支链低级羟基烷基的式（I）的碘化间苯二甲酰胺酸化合物; R2是至少2个碳原子的羟甲基或低级直链或支链烷基，其可以被一个或多个氧原子间隔，或者是Z是碳 - 碳键或直链 - 可被一个或多个氧原子中断的链或支链烃，或当R1不是-CH2-CH2-OH时，是甲基; 及其与生理上可接受的无机或有机碱的盐是x射线造影剂。

    Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
    5.
    发明授权
    Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast 失效
    取代的聚氨基，多羧基络合剂二聚体用于MRI和X射线对比

    公开(公告)号：US5482700A

    公开(公告)日：1996-01-09

    申请号：US269504

    申请日：1994-07-01

    申请人： Julius Deutsch ,  Heinz Gries ,  Erich Klieger ,  Ulrich Niedballa ,  Franz-Josef Renneke ,  Juergen Conrad ,  Wolfgang Muetzel

    发明人： Julius Deutsch ,  Heinz Gries ,  Erich Klieger ,  Ulrich Niedballa ,  Franz-Josef Renneke ,  Juergen Conrad ,  Wolfgang Muetzel

    IPC分类号： A61B5/05 ,  A61K49/04 ,  C07C243/34 ,  A61B5/055

    CPC分类号： C07C243/00 ,  C07C243/34 ,  Y10S514/836 ,  Y10T436/24

    摘要： 1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4,X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83,R.sup.1 and R.sup.2, being different, mean in each case a hydrogen atom or a straight-chain, branched, saturated or unsaturated C.sub.0 -C.sub.20 -alkylene group which optionally contains imino, phenylenoxy, phenylenimino, amido, hydrazido, ester group(s), oxygen, sulfur and/or nitrogen atom(s) and is substituted, if desired, by hydroxy, mercapto, imino, epoxy, oxo, thioxo and/or amino group(s), this alkylene group exhibiting at the end either a second molecule of general Formula I.sub.A or I.sub.B ##STR2## a functional group, or, linked by way of this functional group, a bio- or macromolecule,are valuable diagnostic and therapeutic media.

    摘要翻译： 1.通式I的化合物（I）其中n和m在各种情况下均指数字0,1,2,3和4，X表示氢原子和/或其元素的金属离子当量 原子序数21-29,31,32,37-39,42-44,49或57-83，R1和R2不同，在每种情况下是指氢原子或直链，支链，饱和或不饱和的C0 任选地含有亚氨基，亚苯氧基，亚苯基亚氨基，酰氨基，酰肼基，酯基，氧，硫和/或氮原子的-C 20 - 亚烷基，如果需要，可以被羟基，巯基，亚氨基，环氧基 ，氧代，硫代和/或氨基，该亚烷基末端表示通式IA或IB的第二分子（IA），（IB）官能团，或者由 该功能组的一种生物或大分子是有价值的诊断和治疗媒介。