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    Triiodinated aminoacetamido isophthalamide x-ray contrast agents
    2.
    发明授权
    Triiodinated aminoacetamido isophthalamide x-ray contrast agents 失效
    三碘代氨基乙酰氨基间苯二胺X射线造影剂

    公开(公告)号：US4283381A

    公开(公告)日：1981-08-11

    申请号：US167597

    申请日：1980-07-11

    申请人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    发明人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    IPC分类号： A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C237/46 ,  C07D209/48 ,  C07C103/183 ,  C07C103/50

    CPC分类号： C07D209/48

    摘要： Compounds of the formula ##STR1## wherein X is alkylene, optionally substituted by hydroxy, methoxy or amino;R.sup.1 is hydrogen or C.sub.1-4 alkyl;R.sup.2 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.3 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.4 is hydrogen, C.sub.1-4 -alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.5 is C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.6 is hydrogen, C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-3 OH groups; andR.sup.7 is C.sub.2-4 -alkyl substituted by 1-3 OH groups,or a salt thereof with an acidare useful as opaquing agents in x-ray contrast media.

    摘要翻译： 式（I）的化合物其中X为亚烷基，任选被羟基，甲氧基或氨基取代; R1是氢或C1-4烷基; R2是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R3是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R4是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R5是被1-3个OH基取代的C2-4-烷基; R6是氢，C1-4烷基或被1-3个OH基取代的C2-4烷基; 并且R 7为被1-3个OH基取代的C 2-4烷基，或其与酸的盐可用作x射线造影剂中的不透明剂。

    Novel iodized isophthalamic acid compounds
    3.
    发明授权
    Novel iodized isophthalamic acid compounds 失效
    新型碘化间苯二甲酸化合物

    公开(公告)号：US4132731A

    公开(公告)日：1979-01-02

    申请号：US806383

    申请日：1977-06-14

    申请人： Erich Klieger ,  Ulrich Speck

    发明人： Erich Klieger ,  Ulrich Speck

    IPC分类号： A61K31/195 ,  A61K20060101 ,  A61K49/04 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C237/46 ,  C07C63/12 ,  A61K29/02

    CPC分类号： A61K49/0447

    摘要： Iodized isophthalamic acid compounds of the formula ##STR1## wherein R.sub.1 is straight-chain or branched lower hydroxyalkyl;R.sub.2 is hydroxymethyl or a lower, straight-chain or branched alkyl of at least 2 carbon atoms, which can be interrupted by one or more oxygen atoms, or is ##STR2## wherein Z is a carbon-to-carbon bond or a straight-chain or branched hydrocarbon which can be interrupted by one or more oxygen atoms, or when R.sub.1 is other than --CH.sub.2 --CH.sub.2 --OH, is methyl; and the salts thereof with physiologically acceptable inorganic or organic bases, are x-ray contrast agents.

    摘要翻译： 其中R1是直链或支链低级羟基烷基的式（I）的碘化间苯二甲酰胺酸化合物; R2是至少2个碳原子的羟甲基或低级直链或支链烷基，其可以被一个或多个氧原子间隔，或者是Z是碳 - 碳键或直链 - 可被一个或多个氧原子中断的链或支链烃，或当R1不是-CH2-CH2-OH时，是甲基; 及其与生理上可接受的无机或有机碱的盐是x射线造影剂。

    Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) and x-ray contrast media containing them
    6.
    发明授权
    Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) and x-ray contrast media containing them 失效
    二羧酸（3,5-DICARBAMOYL-2,4,6-TRIIODOANILIDES）和含有它们的X射线对比介质

    公开(公告)号：US5073362A

    公开(公告)日：1991-12-17

    申请号：US554948

    申请日：1990-07-16

    申请人： Peter Blaszkiewicz ,  Ulrich Speck

    发明人： Peter Blaszkiewicz ,  Ulrich Speck

    IPC分类号： A61K31/165 ,  A61K31/166 ,  A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/08 ,  C07C233/00 ,  C07C233/12 ,  C07C237/46

    CPC分类号： A61K31/165 ,  A61K31/166 ,  A61K49/04 ,  C07C233/00 ,  C07C233/12

    摘要： Dicarboxylic acid bis-(3,5-dicarbomoyl-2,4,6-triiodoanilides) of general formula I ##STR1## wherein the amide radicals --CONR.sup.1 R.sup.2 and --CONR.sup.3 R.sup.4 are different from one another andR.sup.1 is a hydrogen, a lower alkyl radical or R.sup.2,R.sup.2 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.3 is hydrogen, a lower alkyl radical or R.sup.4,R.sup.4 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.5 is hydrogen, a lower alkyl radical or a monohydroxy or polyhydroxy alkyl radical,X is a straight-chain or branched-chain alkylene with 1 to 6 carbon atoms, which optionally can be substituted by 1 to 6 hydroxy or alkoxy groups or interrupted by one or more oxygen atoms,possess good pharmacological and physicochemical properties rendering them outstandingly suitable as radiopaque substances in X-ray contrast media for use in all fields of application for X-ray contrast media.

    摘要翻译： 通式Ⅰ“IMAGE”的二羧酸双 - （3,5-二甲酰基-2,4,6-三碘代酰苯胺），其中酰胺基-CONR1R2和-CONR3R4彼此不同，R1是氢，低级烷基 或R2，R2是直链或支链单羟基或多羟基烷基，R3是氢，低级烷基或R4，R4是直链或支链单羟基或多羟基烷基，R5是氢， 低级烷基或单羟基或多羟基烷基，X是具有1至6个碳原子的直链或支链亚烷基，其任选可被1至6个羟基或烷氧基取代或被一个或多个氧中断 原子具有良好的药理学和物理化学性质，使得它们在X射线造影剂中非常适合用作X射线造影剂的所有应用领域中的不透射线物质。

    Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them
    7.
    发明授权
    Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them 失效
    取代的二羧酸 - 双（3​​,5-二氨基甲酰基-2,4,6-三碘苯胺），其制备方法以及含有它们的X射线造影剂

    公开(公告)号：US5004835A

    公开(公告)日：1991-04-02

    申请号：US271464

    申请日：1988-11-15

    申请人： Peter Blaszkiewicz ,  Ulrich Speck

    发明人： Peter Blaszkiewicz ,  Ulrich Speck

    IPC分类号： A61K49/04 ,  B08B3/00 ,  B60S5/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/67 ,  C07C237/46 ,  F02B77/00

    CPC分类号： A61K49/04

    摘要： The invention relates to new substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilines), of general formula I ##STR1## in which R.sup.1 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2, wherein R.sup.1 and R.sup.2 are the same or different,R.sup.2 means a straight-chain or branched-chain C.sub.2 1.varies.C.sub.8 monohydroxyalkyl radical or polyhydroxyalkyl radical,R.sup.3 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2,R.sup.4 means a hydrogen atom or a C.sub.1 -C.sub.4 alkyl radical, andn=1 or 2.The new nonionic compounds of formula I because of their good pharmacological and physiocochemical properties are outstandingly suitable as radiopaque substances in X-ray contrast media for use in all the fields of applications of X-ray contrast media.

    摘要翻译： 本发明涉及通式Ⅰ的新的取代的二羧酸 - 双（3​​,5-二氨基甲酰基-2,4,6-三碘苯胺）（Ⅰ），其中R1表示氢原子，C1-C4烷基 或R 2，其中R 1和R 2相同或不同，R 2表示直链或支链C 21比例C 8单羟基烷基或多羟基烷基，R 3表示氢原子，C 1 -C 4烷基或R 2，R 4表示 氢原子或C 1 -C 4烷基，并且n = 1或2.式I的新型非离子化合物由于其良好的药理学和物理化学性质而非常适合用于所有领域的X射线造影剂中的不透射线物质 的X射线造影剂的应用。

    DRUG-ELUTING MEDICAL DEVICE
    10.
    发明申请
    DRUG-ELUTING MEDICAL DEVICE 审中-公开
    药物治疗设备

    公开(公告)号：US20110295200A1

    公开(公告)日：2011-12-01

    申请号：US13143703

    申请日：2010-01-08

    申请人： Ulrich Speck ,  Silvio Schaffner ,  Magdalena Renke-gluszko

    发明人： Ulrich Speck ,  Silvio Schaffner ,  Magdalena Renke-gluszko

    IPC分类号： A61M25/10 ,  B65B1/04 ,  B05C13/02 ,  A61M29/00 ,  B05C11/00

    CPC分类号： A61L29/16 ,  A61L29/06 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/63 ,  A61M25/1002 ,  A61M25/1029 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/105 ,  C08L77/00

    摘要： The present invention relates to a drug-eluting medical device, in particular a balloon for angioplasty catheters with drug elution to prevent the restenosis of the vessel subjected to angioplasty. More particularly, the present invention relates to a catheter balloon completely or partially coated with paclitaxel in hydrated crystalline form or in hydrated solvated crystalline form, having an immediate release and bioavailability of a therapeutically effective amount of paclitaxel at the site of intervention. The balloon can be made of a polyether-polyamide block copolymer, or a polyester amide, or polyamide-12.

    摘要翻译： 本发明涉及一种药物洗脱医学装置，特别是用于血管成形术导管的气囊，其具有药物洗脱以防止经血管成形术的血管的再狭窄。 更具体地说，本发明涉及完全或部分地涂覆有水合结晶形式的紫杉醇或水合溶剂化晶体形式的导管球囊，其在干预部位具有治疗有效量的紫杉醇的即时释放和生物利用度。 气球可以由聚醚 - 聚酰胺嵌段共聚物或聚酯酰胺或聚酰胺-12制成。