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90 条记录 (耗时 0.028 秒)

    Triiodinated aminoacetamido isophthalamide x-ray contrast agents
    1.
    发明授权
    Triiodinated aminoacetamido isophthalamide x-ray contrast agents 失效
    三碘代氨基乙酰氨基间苯二胺X射线造影剂

    公开(公告)号：US4283381A

    公开(公告)日：1981-08-11

    申请号：US167597

    申请日：1980-07-11

    申请人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    发明人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    IPC分类号： A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C237/46 ,  C07D209/48 ,  C07C103/183 ,  C07C103/50

    CPC分类号： C07D209/48

    摘要： Compounds of the formula ##STR1## wherein X is alkylene, optionally substituted by hydroxy, methoxy or amino;R.sup.1 is hydrogen or C.sub.1-4 alkyl;R.sup.2 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.3 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.4 is hydrogen, C.sub.1-4 -alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.5 is C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.6 is hydrogen, C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-3 OH groups; andR.sup.7 is C.sub.2-4 -alkyl substituted by 1-3 OH groups,or a salt thereof with an acidare useful as opaquing agents in x-ray contrast media.

    摘要翻译： 式（I）的化合物其中X为亚烷基，任选被羟基，甲氧基或氨基取代; R1是氢或C1-4烷基; R2是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R3是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R4是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R5是被1-3个OH基取代的C2-4-烷基; R6是氢，C1-4烷基或被1-3个OH基取代的C2-4烷基; 并且R 7为被1-3个OH基取代的C 2-4烷基，或其与酸的盐可用作x射线造影剂中的不透明剂。

    Novel iodized isophthalamic acid compounds
    3.
    发明授权
    Novel iodized isophthalamic acid compounds 失效
    新型碘化间苯二甲酸化合物

    公开(公告)号：US4132731A

    公开(公告)日：1979-01-02

    申请号：US806383

    申请日：1977-06-14

    申请人： Erich Klieger ,  Ulrich Speck

    发明人： Erich Klieger ,  Ulrich Speck

    IPC分类号： A61K31/195 ,  A61K20060101 ,  A61K49/04 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C237/46 ,  C07C63/12 ,  A61K29/02

    CPC分类号： A61K49/0447

    摘要： Iodized isophthalamic acid compounds of the formula ##STR1## wherein R.sub.1 is straight-chain or branched lower hydroxyalkyl;R.sub.2 is hydroxymethyl or a lower, straight-chain or branched alkyl of at least 2 carbon atoms, which can be interrupted by one or more oxygen atoms, or is ##STR2## wherein Z is a carbon-to-carbon bond or a straight-chain or branched hydrocarbon which can be interrupted by one or more oxygen atoms, or when R.sub.1 is other than --CH.sub.2 --CH.sub.2 --OH, is methyl; and the salts thereof with physiologically acceptable inorganic or organic bases, are x-ray contrast agents.

    摘要翻译： 其中R1是直链或支链低级羟基烷基的式（I）的碘化间苯二甲酰胺酸化合物; R2是至少2个碳原子的羟甲基或低级直链或支链烷基，其可以被一个或多个氧原子间隔，或者是Z是碳 - 碳键或直链 - 可被一个或多个氧原子中断的链或支链烃，或当R1不是-CH2-CH2-OH时，是甲基; 及其与生理上可接受的无机或有机碱的盐是x射线造影剂。

    Use of intravenous contrast media for projection mammography
    8.
    发明申请
    Use of intravenous contrast media for projection mammography 审中-公开
    使用静脉造影剂进行投影乳房X线摄影

    公开(公告)号：US20050008574A1

    公开(公告)日：2005-01-13

    申请号：US10851213

    申请日：2004-05-24

    申请人： Ulrich Speck ,  Irtel Von Brenndorff

    发明人： Ulrich Speck ,  Irtel Von Brenndorff

    IPC分类号： A61B6/00 ,  A61K49/00 ,  A61K49/04 ,  A61K49/06 ,  A61P35/04 ,  G06T5/00 ,  G06T5/50

    CPC分类号： A61K49/0409 ,  A61K49/0457

    摘要： The invention relates to the use of intravenous contrast media for projection mammography as well as new devices for projection mammography. The invention therefore relates to the use of intravenous contrast media for the production of a diagnostic agent for projection mammography. Through the additional intravenous administration of contrast media, projection mammography achieves a sensitivity that is comparable to that of the most modern processes such as magnetic resonance tomography (MRT) while being considerably more versatile and avoiding the costs of MRT. The new process can be implemented simply and without special stress on the patients and provides a significant improvement in a) sensitivity to the detection of focal lesions in the breast, and b) additional information on the nature of lesions detected previously.

    摘要翻译： 本发明涉及用于投影乳房X线照相术的静脉造影剂的使用以及用于投影乳房X线照相术的新装置。 因此，本发明涉及静脉造影剂用于生产用于投影乳房X线照相术的诊断剂的用途。 通过额外静脉注射造影剂，投影乳房X线照相术的灵敏度可以达到最现代的方法，如磁共振断层扫描（MRT）的灵敏度，同时具有更大的灵活性，避免了MRT的成本。 新过程可以简单实现，对患者没有特别的压力，并且对a）对乳房局灶性病变检测的敏感度以及b）关于先前检测到的病变性质的额外信息提供了显着的改善。