公开(公告)号：US11155868B2

公开(公告)日：2021-10-26

申请号：US17155226

申请日：2021-01-22

Applicant: Ultima Genomics, Inc.

Inventor： Gilad Almogy ,  Nathan Beckett ,  Jacob A. Wolf ,  Nathan Caswell ,  Joseph Anthony ,  Jose Martin Sosa ,  Phillip Lee ,  Stephanie Kubecka

IPC: C12Q1/6874 ,  C12Q1/6825 ,  C12Q1/6809 ,  B01J19/00 ,  B01L3/00

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US11268143B2

公开(公告)日：2022-03-08

申请号：US17308241

申请日：2021-05-05

Applicant: Ultima Genomics, Inc.

Inventor： Nathan Beckett ,  Gilad Almogy ,  Nathan Caswell ,  Jacob A. Wolf ,  Kristopher Barbee ,  Denis Pristinski ,  Mark Pratt ,  Gene Polovy ,  Osip Schwartz ,  Stephanie Kubecka ,  Steven Menchen ,  Joseph Anthony ,  Jose Martin Sosa ,  Phillip You Fai Lee

IPC: C12Q1/68 ,  G01N35/10 ,  C12Q1/6874

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US11118223B2

公开(公告)日：2021-09-14

申请号：US16953071

申请日：2020-11-19

Applicant: Ultima Genomics, Inc.

Inventor： Gilad Almogy ,  Nathan Beckett ,  Stephanie Kubecka

IPC: G01N35/00 ,  C12Q1/6874 ,  G01N35/10 ,  C12Q1/68

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US12031180B2

公开(公告)日：2024-07-09

申请号：US17543521

申请日：2021-12-06

Applicant: Ultima Genomics, Inc.

Inventor： Nathan Beckett ,  Gilad Almogy ,  Nathan Caswell ,  Jacob A. Wolf ,  Kristopher Barbee ,  Denis Pristinski ,  Mark Pratt ,  Gene Polovy ,  Osip Schwartz ,  Stephanie Kubecka ,  Steven Menchen ,  Joseph Anthony ,  Jose Martin Sosa ,  Phillip You Fai Lee

IPC: C12Q1/6874 ,  G01N35/10

CPC classification number: C12Q1/6874 ,  G01N35/1002

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US20220064727A1

公开(公告)日：2022-03-03

申请号：US17475256

申请日：2021-09-14

Applicant: Ultima Genomics, Inc.

Inventor： Gilad Almogy ,  Nathan Beckett ,  Jacob A. Wolf ,  Nathan Caswell ,  Joseph Anthony ,  Jose Martin Sosa ,  Phillip Lee ,  Stephanie Kubecka

IPC: C12Q1/6874 ,  C12Q1/6825 ,  C12Q1/6809 ,  B01J19/00 ,  B01L3/00

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US10900078B2

公开(公告)日：2021-01-26

申请号：US16445798

申请日：2019-06-19

Applicant: Ultima Genomics, Inc.

Inventor： Gilad Almogy ,  Nathan Beckett ,  Jacob A. Wolf ,  Nathan Caswell ,  Joseph Anthony ,  Jose Martin Sosa ,  Phillip Lee ,  Stephanie Kubecka

IPC: C12Q1/6874 ,  C12Q1/6825 ,  C12Q1/6809 ,  B01J19/00 ,  B01L3/00

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.