公开(公告)号：US09393326B2

公开(公告)日：2016-07-19

申请号：US14205670

申请日：2014-03-12

Applicant: University Health Network

Inventor： David Jaffray ,  Christine Allen ,  Jinzi Zheng ,  Raymond Matthew Reilly ,  Gregory Jason Perkins

IPC: A61K49/00 ,  A61K51/00 ,  A61K49/04 ,  A61B5/00 ,  A61B6/00 ,  A61B8/08 ,  A61K9/127 ,  A61K49/18 ,  A61K51/12 ,  A61B5/055 ,  A61B8/00

CPC classification number: A61K49/04 ,  A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B6/00 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/5238 ,  A61K9/127 ,  A61K9/1271 ,  A61K49/0002 ,  A61K49/0466 ,  A61K49/1812 ,  A61K51/1234

Abstract: There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.

Abstract translation: 提供了用于医学成像的信号调节组合物，其包含对两种或多种成像模态特异的载体和信号调节剂。 所述组合物的特征在于保留效率，关于信号调节剂，其能够延长对比成像，而不会从载体中显着消耗信号调节剂。 本发明的载体是基于脂质或聚合物的，其物理化学性质可被修饰以捕获或螯合不同的信号调节剂及其混合物，并靶向哺乳动物内的特定器官或肿瘤或组织。

公开(公告)号：US11607454B2

公开(公告)日：2023-03-21

申请号：US16303400

申请日：2017-05-19

Applicant: UNIVERSITY HEALTH NETWORK ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Brian Wilson ,  Christine Allen

IPC: A61K41/00 ,  A61N5/10

Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.

公开(公告)号：US11077214B2

公开(公告)日：2021-08-03

申请号：US14892444

申请日：2014-05-26

Applicant: University Health Network

Inventor： Jinzi Zheng ,  David A. Jaffray ,  Christine Allen

IPC: A61K49/04 ,  A61K49/00

Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.

公开(公告)号：US20160095944A1

公开(公告)日：2016-04-07

申请号：US14892444

申请日：2014-05-26

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Jinzi Zheng ,  David A. Jaffray ,  Christine Allen

IPC: A61K49/04

CPC classification number: A61K49/0466 ,  A61K49/0084

Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.

Abstract translation: 本申请涉及包含碘化造影剂和共同包封在脂质体载体内的吲哚菁绿的组合物，其各种用途以及它们的制备方法。