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公开(公告)号：US11504075B2
公开(公告)日：2022-11-22
申请号：US16227845
申请日：2018-12-20
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Edward Taylor , David A. Jaffray , Ivan Wai Tong Yeung
IPC: A61B6/00 , A61B6/03 , G16H30/40 , A61B5/055 , A61K49/00 , G01T1/161 , G06T7/00 , A61K51/04 , G06T11/00 , G01T1/29
Abstract: Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (vd) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced—that is, trapping rates k3 are only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate k3 and TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate kb, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.
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公开(公告)号：US11266383B2
公开(公告)日：2022-03-08
申请号：US15762143
申请日：2016-09-22
Applicant: University Health Network
Inventor： Arash Zarrine-Afsar , David A. Jaffray , Alessandra Tata , Michael Woolman , Alexander Vitkin
IPC: G01N21/00 , A61B10/02 , A61B18/20 , H01J49/04 , G01N21/21 , A61B34/10 , A61B5/00 , A61B5/055 , A61B6/03 , A61B8/08 , A61B18/12 , H01J49/00 , A61B34/20 , A61B18/00
Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.
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3.发明授权公开(公告)号：US09545231B2
公开(公告)日：2017-01-17
申请号：US13842683
申请日：2013-03-15
Applicant: University Health Network
Inventor： David A. Jaffray , Sean Alexander Graham , Jeffrey Harold Siewerdsen , Steven Joe Bartolac
CPC classification number: A61B6/032 , A61B6/035 , A61B6/06 , A61B6/405 , A61B6/5282 , A61B6/542 , A61B6/545 , G21K1/04 , G21K1/043 , G21K1/046
Abstract: A method and imaging system for operating imaging computed tomography using at least one radiation source and at least one detector to generate an image of an object. The method includes: defining desired image characteristics; and performing calculations to determine the pattern of fluence to be applied by the at least one radiation source, to generate said desired image quality or characteristics. Then, the at least one radiation source is modulated, to generate the intended pattern of fluence between the beam source and the object to be imaged. The desired image characteristics can provide at least one of: desired image quality in at least one defined region of interest; and at least one desired distribution of said image quality.
Abstract translation: 一种用于使用至少一个辐射源和至少一个检测器来操作成像计算机断层摄影术以产生对象的图像的方法和成像系统。 该方法包括：定义所需的图像特征; 以及执行计算以确定要由所述至少一个辐射源施加的注量的模式，以产生所述期望的图像质量或特性。 然后，对该至少一个辐射源进行调制，以产生射束源和待成像对象之间的注量图形。 期望的图像特征可以提供至少一个：在至少一个限定的感兴趣区域中的期望图像质量; 以及所述图像质量的至少一个期望分布。
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公开(公告)号：US11385360B2
公开(公告)日：2022-07-12
申请号：US15578743
申请日：2016-06-03
Applicant: University Health Network
Abstract: Various embodiments are described herein for sensors that may be used to measure radiation from radiation generating device. The sensors may use a collector plate electrode with first and second collection regions having shapes that are inversely related with one another to provide ion chambers with varying sample volumes along a substantial portion of the first and second collection regions which provides virtual spatial sensitivity during use.
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公开(公告)号：US10001570B1
公开(公告)日：2018-06-19
申请号：US15055720
申请日：2016-02-29
Applicant: University Health Network
Inventor： David A. Jaffray
CPC classification number: G01T1/2985
Abstract: An apparatus for high resolution positron emission tomography (PET) imaging. The apparatus includes at least a first detector and a second detector arranged to detect gamma rays traveling from a target area, the first detector and the second detector being a detector pair. There is at least one collimator for filtering gamma rays reaching the first and second detectors. The collimator defines respective passages filtering gamma rays reaching the respective first and second detectors, the passages being defined to filter for only gamma ray pairs traveling from the target area at a predetermined range of angles with respect to each other, the predetermined range of angles being in the range of 180°-θE, where θE is less than 1° and greater than 0°.
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Patent Agency Ranking
公开(公告)号：US20160095944A1
公开(公告)日：2016-04-07
申请号：US14892444
申请日：2014-05-26
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Jinzi Zheng , David A. Jaffray , Christine Allen
IPC: A61K49/04
CPC classification number: A61K49/0466 , A61K49/0084
Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.
Abstract translation: 本申请涉及包含碘化造影剂和共同包封在脂质体载体内的吲哚菁绿的组合物，其各种用途以及它们的制备方法。
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公开(公告)号：US11077214B2
公开(公告)日：2021-08-03
申请号：US14892444
申请日：2014-05-26
Applicant: University Health Network
Inventor： Jinzi Zheng , David A. Jaffray , Christine Allen
Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.
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公开(公告)号：US20180271502A1
公开(公告)日：2018-09-27
申请号：US15762143
申请日：2016-09-22
Applicant: University Health Network
Inventor： Arash Zarrine-Afsar , David A. Jaffray , Alessandra Tata , Michael Woolman , Alexander Vitkin
IPC: A61B10/02 , H01J49/00 , H01J49/04 , A61B34/10 , A61B18/12 , A61B18/20 , A61B5/00 , A61B5/055 , A61B6/03 , A61B8/08
CPC classification number: A61B10/0266 , A61B5/0095 , A61B5/055 , A61B6/032 , A61B6/037 , A61B8/085 , A61B10/0233 , A61B18/12 , A61B18/20 , A61B34/10 , A61B2018/00577 , A61B2018/00595 , A61B2018/00904 , A61B2034/107 , A61B2034/2072 , G01N21/21 , H01J49/0004 , H01J49/0031 , H01J49/04
Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments. polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.
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公开(公告)号：US20180172845A1
公开(公告)日：2018-06-21
申请号：US15578743
申请日：2016-06-03
Applicant: University Health Network
CPC classification number: G01T1/185 , G01T1/2935 , H01J47/02
Abstract: Various embodiments are described herein for sensors that may be used to measure radiation from radiation generating device. The sensors may use a collector plate electrode with first and second collection regions having shapes that are inversely related with one another to provide ion chambers with varying sample volumes along a substantial portion of the first and second collection regions which provides virtual spatial sensitivity during use.
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10.发明申请OPTIMIZED APERTURE SELECTION IMAGING COMPUTED TOMOGRAPHY SYSTEM AND METHOD 有权优化的APERTURE选择成像计算机图像系统和方法公开(公告)号：US20130294572A1
公开(公告)日：2013-11-07
申请号：US13842683
申请日：2013-03-15
Applicant: University Health Network
Inventor： David A. Jaffray , Sean Alexander Graham , Jeffrey Harold Siewerdsen , Steven Joe Bartolac
IPC: A61B6/03
CPC classification number: A61B6/032 , A61B6/035 , A61B6/06 , A61B6/405 , A61B6/5282 , A61B6/542 , A61B6/545 , G21K1/04 , G21K1/043 , G21K1/046
Abstract: A method and imaging system for operating imaging computed tomography using at least one radiation source and at least one detector to generate an image of an object. The method includes: defining desired image characteristics; and performing calculations to determine the pattern of fluence to be applied by the at least one radiation source, to generate said desired image quality or characteristics. Then, the at least one radiation source is modulated, to generate the intended pattern of fluence between the beam source and the object to be imaged. The desired image characteristics can provide at least one of: desired image quality in at least one defined region of interest; and at least one desired distribution of said image quality.
Abstract translation: 一种用于使用至少一个辐射源和至少一个检测器来操作成像计算机断层摄影术以产生对象的图像的方法和成像系统。 该方法包括：定义所需的图像特征; 以及执行计算以确定要由所述至少一个辐射源施加的注量的模式，以产生所述期望的图像质量或特性。 然后，对该至少一个辐射源进行调制，以产生射束源和待成像对象之间的注量图形。 期望的图像特征可以提供至少一个：在至少一个限定的感兴趣区域中的期望图像质量; 以及所述图像质量的至少一个期望分布。
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