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公开(公告)号：US11857313B2
公开(公告)日：2024-01-02
申请号：US16645952
申请日：2018-09-11
发明人： Jason C. Heikenfeld
CPC分类号： A61B5/14517 , A61B5/1451 , A61B5/14503 , A61B5/14532 , A61B5/6802
摘要： A system 100, 200 for sensing one or more analytes in a first biofluid and a second biofluid and methods of using said system. The system 100, 200 may include a first subsystem 102, 200a, 200b with a first sensor 120, 122, 220, 222 for sensing a first analyte in the first biofluid and a second subsystem 104, 200b, 200c with a second sensor 124, 126, 222, 224 for sensing a second analyte in the second biofluid. The second analyte may be the same as or different from the first analyte and the second biofluid may be different from the first biofluid. In an embodiment, the first biofluid is a non-sweat biofluid and the second biofluid is sweat. The system 100, 200 may be used to detect lag time for measuring an analyte in one of the biofluids.
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公开(公告)号：US20200077988A1
公开(公告)日：2020-03-12
申请号：US16468464
申请日：2017-12-20
发明人： Jason C. Heikenfeld
IPC分类号： A61B10/00 , A61B5/145 , A61B5/00 , A61B5/1477
摘要： A device (100) for sensing a first analyte in sweat on skin includes an analyte-specific sensor (120) for sensing the first analyte and an active sweat coupling component (130) for transporting at least one sweat sample inside the device (100) and into fluid communication with the analyte-specific sensor (120). A method of sensing a first analyte in sweat on skin includes actively transporting at least one sweat sample into fluid communication with an analyte-specific sensor (120) for sensing the first analyte using an active sweat coupling component (130) and sensing the first analyte using the analyte-specific sensor (120).
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公开(公告)号：US20190029654A1
公开(公告)日：2019-01-31
申请号：US16069658
申请日：2017-01-13
摘要： A method of collecting and sensing a biofluid with enhanced concentration of analytes due to electroporation comprises electroporating biofluid glands (14) that are generating a biofluid and specifically sensing at least one analyte in said biofluid, the at least one analyte having a molecular weight greater than 50 Da. A device (100) wearable on a user's skin (12) for receiving an advective flow of a biofluid comprises at least one of a biofluid stimulation component (140), a biofluid sensor (220, 222) specific to an analyte, or a biofluid collection element (230, 232), at least one electroporation electrode (290) for enhancing concentration of at least one analyte in the biofluid having a molecular weight of greater than 50 Da, a counter electrode (195), and an electroporation waveform generator configured to cause the electroporation electrode (290) to generate and direct a plurality of electroporation pulses into the skin (12).
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公开(公告)号：US09625705B2
公开(公告)日：2017-04-18
申请号：US14676927
申请日：2015-04-02
发明人： Kenneth A. Dean , Jason C. Heikenfeld , Kaichang Zhou , Hari Mukunda Atkuri , Wyatt Austin Black Rodgers
IPC分类号： G02B26/00
CPC分类号： G02B26/005
摘要： A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate; providing a second plate and sealing a second plate onto the first plate forming stacked plates with at least one cavity between the plates, and leaving at least one fill port for a second fluid. Thereafter, the stacked plates are cooled to increase the viscosity of the first fluid so that the first fluid maintains a fixed position as a second fluid is filled into the cavity. Methods are disclosed.
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公开(公告)号：US20170095233A1
公开(公告)日：2017-04-06
申请号：US15314418
申请日：2015-05-28
发明人： Jason C. Heikenfeld
CPC分类号： A61B10/0064 , A61B5/0531 , A61B5/0537 , A61B5/14521 , A61B5/4266 , A61B5/6833 , A61B2560/0412
摘要： A sweat sensor device (400c) for sensing sweat on the skin (12) includes one or more sweat sensors (420) and a volume-reducing component that provides a volume-reduced pathway (480) for sweat between the one or more sweat sensors (420) and sweat glands in said skin (12) when the device (400c) is positioned on said skin (12). The volume-reducing component may include a volume-reducing material (470) and a pressure-permeated component (460), a sweat dissolvable material (490), a mechanically compliant material (570) for conforming to the skin (12), an adhesive with a vertically anisotropic sweat pathway, and microcap sules (1385) including a barrier material. The presence of a volume-reducing component reduces the sweat volume and decreases the sampling interval.
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公开(公告)号：US20150112165A1
公开(公告)日：2015-04-23
申请号：US14516974
申请日：2014-10-17
发明人： Jason C. Heikenfeld
CPC分类号： A61B5/0531 , A61B5/14521 , A61B5/4266 , A61B5/443 , A61B5/7221 , A61B5/7292 , A61B10/0064 , A61B2018/00654 , A61B2018/124 , A61B2562/0295 , A61B2562/168
摘要： Devices that sense sweat and are capable of providing chronological assurance are described. The device uses at least one sensor to measure sweat or its components and to determine a sweat sampling rate. The chronological assurance is determined, at least in part, using the sweat sampling rate. The sweat sampling rate may be determined, at least in part, using a sweat volume and/or a sweat generation rate, both of which may be measured or predetermined.
摘要翻译： 描述感觉汗水并且能够提供按时间顺序的保证的装置。 该装置使用至少一个传感器来测量汗液或其组分并确定汗液采样率。 至少部分地使用汗水采样率来确定时间顺序的保证。 可以至少部分地使用汗液体积和/或汗液产生速率确定汗液采样率，这两者可以被测量或预定。
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7.发明公开公开(公告)号：US20230417102A1
公开(公告)日：2023-12-28
申请号：US18458422
申请日：2023-08-30
IPC分类号： E06B9/24 , G02B26/00 , G02B26/02 , G02F1/16762 , G02F1/16756 , G02F1/1679 , G02F1/167
CPC分类号： E06B9/24 , G02B26/007 , G02B26/026 , G02F1/16762 , G02F2001/1678 , G02F1/1679 , G02F1/167 , E06B2009/2464 , G02F1/16756
摘要： A laminate which can serve as either a smart window or a smart mirror is formed using first and second substrates coated with transparent first and second electrodes which are separated by foraminous layer and a third grid-like linear electrode insulated from the first and second electrodes. The foraminous layer includes spacers defining a cell space which is filled with a colloidal ink having first and second particles. The first particles have a positive charge and a first color and second particles having a negative charge and a second color different from the first color. By altering the voltages of the first, second and third electrodes, one can achieve different light transmission characteristics which, for example, can alter the color temperature of the light transmitted through the laminate or enhance reflective colors.
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公开(公告)号：US11369349B2
公开(公告)日：2022-06-28
申请号：US16468464
申请日：2017-12-20
发明人： Jason C. Heikenfeld
IPC分类号： A61B10/00 , A61B5/145 , A61B5/1477 , A61B5/00
摘要： A device (100) for sensing a first analyte in sweat on skin includes an analyte-specific sensor (120) for sensing the first analyte and an active sweat coupling component (130) for transporting at least one sweat sample inside the device (100) and into fluid communication with the analyte-specific sensor (120). A method of sensing a first analyte in sweat on skin includes actively transporting at least one sweat sample into fluid communication with an analyte-specific sensor (120) for sensing the first analyte using an active sweat coupling component (130) and sensing the first analyte using the analyte-specific sensor (120).
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9.发明授权公开(公告)号：US10182795B2
公开(公告)日：2019-01-22
申请号：US14516962
申请日：2014-10-17
IPC分类号： A61B5/05 , A61B10/00 , A61B5/053 , A61B5/1491 , A61B5/00 , A61N1/32 , A61B5/145 , A61B5/0408
摘要： A sweat sensing device includes a plurality of sweat collection pads communicating with a sensor. Each of the pads is activated by a timing circuit which allows one or more of the pads to be activated at a selected time and subsequent deactivated after a defined period of time. This allows for selective collection of sweat from a plurality of pads over a prolonged period of time. An impedance measuring circuit can be employed to determine if one or more of the pads becomes disconnected, in order to avoid irritation. Further, the devices can use a common microfluidic device which both transports sweat activating substance, such as pilocarpine, to the surface of the skin and directs sweat away from the skin to a sensing device.
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公开(公告)号：US20170245788A1
公开(公告)日：2017-08-31
申请号：US15512982
申请日：2015-09-22
发明人： Jason C. Heikenfeld
IPC分类号： A61B5/145 , A61B5/1495 , A61B5/00
CPC分类号： A61B5/14517 , A61B5/1495 , A61B5/4266 , A61B5/6801 , A61B5/6832 , A61B2560/0223
摘要： A sweat sensor device (200) with analytical assurance includes at least one sensor (220) for detecting a first analyte, and at least one calibration medium (270) containing at least the first analyte. When the first analyte in the at least one calibration medium (270) comes into contact with the at least one sensor (220), the calibration medium (270) provides a calibration of the at least one sensor (220). A sweat sensor device (200) may further include a carrier (240) having at least one aperture (220a) and a reservoir (254) for storing the at least one calibration medium (270). The at least one aperture (220a) provides fluidic access to the at least one sensor (220) from the reservoir (254).
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