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    Microfluidic methods for passive separation of cells and particles
    1.
    发明授权
    Microfluidic methods for passive separation of cells and particles 有权

    公开(公告)号：US10512913B2

    公开(公告)日：2019-12-24

    申请号：US15983815

    申请日：2018-05-18

    Applicant: University Of Cincinnati

    Inventor： Ian Papautsky ,  Jian Zhou

    IPC: B01L3/00 ,  B01J19/00 ,  B03B5/62 ,  B07B7/00

    Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.

    MICROFLUIDIC METHODS FOR PASSIVE SEPARATION OF CELLS AND PARTICLES
    2.
    发明申请
    MICROFLUIDIC METHODS FOR PASSIVE SEPARATION OF CELLS AND PARTICLES 有权
    用于被动分离细胞和颗粒的微流化方法

    公开(公告)号：US20140374324A1

    公开(公告)日：2014-12-25

    申请号：US14376450

    申请日：2013-02-01

    Applicant: University of Cincinnati

    Inventor： Ian Papautsky ,  Jian Zhou

    IPC: B01L3/00 ,  B07B7/00 ,  B03B5/62

    CPC classification number: B01L3/502761 ,  B01J19/0093 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00984 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B03B5/62 ,  B07B7/00 ,  Y10T137/0318

    Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.

    Abstract translation: 一种从流体的一部分分离多个颗粒（14）的方法，包括将多个颗粒（14）引导到微通道（12）中。 颗粒（14）的第一部分（16）被聚焦到微通道（12）中的平衡位置。 聚焦的第一部分（16）被引导到与平衡位置对准的第一出口（18）中。 一部分流体被引导到一个或多个出口（20,22）中。 一种用于从流体的一部分分离多个颗粒（14）的微流体装置（10），包括具有第一长宽比和长度L的微通道（12），从而将引导到其中的颗粒（14）聚焦到平衡位置 在所述微通道中，其中所述颗粒（14）的至少第一部分（16）以与所述微通道（12）的开始处的距离X聚焦。 在第一部分（16）聚焦到微通道（12）中的平衡位置之后，设置在距离X之后并与平衡位置对准的第一出口（18）以接收至少第一部分（16） 。 至少第二出口（20），用于在第二部分聚焦到平衡位置之前接收颗粒（14）的第二部分。

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