公开(公告)号：US20240101916A1

公开(公告)日：2024-03-28

申请号：US18535047

申请日：2023-12-11

Applicant: Shandong Tsingchuang Chemicals Co. Ltd.

Inventor： Guiguang CHEN ,  Chengjin WANG ,  Mian DUANMU ,  Yong SUN

IPC: C10L1/02 ,  B01J14/00 ,  B01J19/00 ,  B01J19/24 ,  C10G3/00 ,  C11C3/10

CPC classification number: C10L1/026 ,  B01J14/00 ,  B01J19/0066 ,  B01J19/0093 ,  B01J19/242 ,  C10G3/42 ,  C11C3/10 ,  B01J2219/00033 ,  B01J2219/00889 ,  B01J2219/00905 ,  C10G2400/04 ,  C10L2200/0476 ,  C10L2200/0484

Abstract: A micro-reaction device for preparing biodiesel by base catalysis includes a feeding system, a micro-reaction apparatus, and a separation apparatus. The feeding system is in communication with the micro-reaction apparatus, and the micro-reaction apparatus is in communication with the separation apparatus; the micro-reaction apparatus includes a micro-reactor, and the micro-reactor is a micro-dispersion micro-reactor; in the micro-reaction apparatus, an oil phase and short chain alcohols undergo an ester exchange reaction under base catalysis to generate fatty acid esters and by-product glycerol; and the micro-dispersion reactor is provided with a micro-dispersion structure for dispersing the short chain alcohols into micro-droplets. By the solution of the present application, the intrinsic safety of a process is improved, the reaction time is greatly shortened, the resistance to material flow is lower, the system operating pressure is low, and the single-channel treatment capacity is large, which is 10-500 times that of a micro-channel reactor.

公开(公告)号：US09987632B2

公开(公告)日：2018-06-05

申请号：US14376450

申请日：2013-02-01

Applicant: University of Cincinnati

Inventor： Ian Papautsky ,  Jian Zhou

IPC: B07B7/00 ,  B01L3/00 ,  B01J19/00 ,  B03B5/62

CPC classification number: B01L3/502761 ,  B01J19/0093 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00984 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B03B5/62 ,  B07B7/00 ,  Y10T137/0318

Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.

公开(公告)号：US09636655B2

公开(公告)日：2017-05-02

申请号：US13314170

申请日：2011-12-07

Applicant: Lester F. Ludwig

Inventor： Lester F. Ludwig

IPC: B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  G01N35/00

CPC classification number: B01J19/0093 ,  B01J2219/00835 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00905 ,  B01J2219/00986 ,  B01J2219/00997 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L9/52 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/086 ,  G01N35/0092 ,  Y10T436/12

Abstract: Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or smallscale chemical manufacturing.

公开(公告)号：US09546143B2

公开(公告)日：2017-01-17

申请号：US15201274

申请日：2016-07-01

Applicant: NANJING TECH UNIVERSITY (CN)

Inventor： Kai Guo ,  Zheng Fang ,  Xin Li ,  Ning Zhu ,  Li Wan ,  Wei He ,  Kai Zhang ,  Pingkai Ouyang

IPC: C07D301/18 ,  C07D301/16 ,  B01J19/00

CPC classification number: C07D301/16 ,  B01J19/0093 ,  B01J2219/00795 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905

Abstract: A method for preparing a high-quality epoxidized fatty acid ester with a micro-reaction device, including: respectively pumping an aqueous hydrogen peroxide solution and a carboxylic acid at the same time into a first micro-mixer; after the reaction in the first micro-reactor, respectively pumping the output material and an unsaturated fatty acid ester into a second micro-mixer;completely mixing them and then introducing the mixture into a second micro-reactor; and after a complete reaction, water-rinsing the organic phase part of the resultant reaction liquid and drying the same to obtain the epoxidized fatty acid ester.

Abstract translation: 完全混合，然后将混合物引入第二个微反应器; 在完全反应之后，水洗所得反应液的有机相部分并将其干燥，得到环氧化脂肪酸酯。

公开(公告)号：US09421284B2

公开(公告)日：2016-08-23

申请号：US14235005

申请日：2012-12-26

Applicant: Hitachi, Ltd.

Inventor： Nami Sugita ,  Naomi Manri ,  Wataru Takeuchi ,  Yuichi Morimoto ,  Hiroko Hanzawa

IPC: B01J19/24 ,  A61K51/08 ,  B01J19/00 ,  B01L3/00 ,  B01F13/00 ,  C07B59/00

CPC classification number: A61K51/088 ,  B01F13/0062 ,  B01F13/0066 ,  B01J19/0006 ,  B01J19/0093 ,  B01J19/24 ,  B01J2219/00049 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00842 ,  B01J2219/00873 ,  B01J2219/0088 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/24 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  C07B59/00 ,  Y10T436/12

Abstract: A reaction container in which to mix a first chemical compound with a second chemical compound has a main body and a lid member formed oppositely on a top face side of the main body; a flow channel on the top face of the main body; and a labeling agent solidification section at an intermediate section of the flow channel to remove a solvent in a solution of the second chemical compound and solidify the second chemical compound. First and second chemical compound supply sections and a mixture discharge section are formed on the upstream and downstream sides of the labeling agent solidification section, respectively. The reactor is provided with a liquid sending unit to supply the first and second chemical compounds and reciprocally send a solution of the first chemical compound to an upper part of the second chemical compound solidified at the solidification section.

Abstract translation: 将第一化合物与第二化合物混合的反应容器具有主体和在主体的顶面相对地形成的盖部件; 主体顶面上的流路; 以及在流路的中间部分处的标记剂固化部分，以除去第二化合物的溶液中的溶剂并固化第二化合物。 分别在标签试剂凝固部的上游侧和下游侧形成第一和第二化合物供给部和混合物排出部。 反应器设有一个送液单元，用于供应第一和第二化合物，并将第一化合物的溶液往凝固段固化的第二化合物的上部相互转移。

公开(公告)号：US20150335769A1

公开(公告)日：2015-11-26

申请号：US14235005

申请日：2012-12-26

Applicant: Hitachi, Ltd.

Inventor： Nami SUGITA ,  Naomi MANRI ,  Wataru TAKEUCHI ,  Yuichi MORIMOTO ,  Hiroko HANZAWA

IPC: A61K51/08 ,  B01J19/24 ,  B01J19/00

CPC classification number: A61K51/088 ,  B01F13/0062 ,  B01F13/0066 ,  B01J19/0006 ,  B01J19/0093 ,  B01J19/24 ,  B01J2219/00049 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00842 ,  B01J2219/00873 ,  B01J2219/0088 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/24 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  C07B59/00 ,  Y10T436/12

Abstract: A reaction container in which to mix a first chemical compound with a second chemical compound has a main body and a lid member formed oppositely on a top face side of the main body; a flow channel on the top face of the main body; and a labeling agent solidification section at an intermediate section of the flow channel to remove a solvent in a solution of the second chemical compound and solidify the second chemical compound. First and second chemical compound supply sections and a mixture discharge section are formed on the upstream and downstream sides of the labeling agent solidification section, respectively. The reactor is provided with a liquid sending unit to supply the first and second chemical compounds and reciprocally send a solution of the first chemical compound to an upper part of the second chemical compound solidified at the solidification section.

Abstract translation: 将第一化合物与第二化合物混合的反应容器具有主体和在主体的顶面相对地形成的盖部件; 主体顶面上的流路; 以及在流路的中间部分处的标记剂固化部分，以除去第二化合物的溶液中的溶剂并固化第二化合物。 分别在标签试剂凝固部的上游侧和下游侧形成第一和第二化合物供给部和混合物排出部。 反应器设有一个送液单元，用于供应第一和第二化合物，并将第一化合物的溶液往凝固段固化的第二化合物的上部相互转移。

公开(公告)号：US20150152206A1

公开(公告)日：2015-06-04

申请号：US14406202

申请日：2013-06-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Pei Yuin Keng ,  Rehana Ismail ,  Ariella Machness ,  Kyoung-Joo Jenny Park

IPC: C08F212/14 ,  B01J19/00 ,  C08F236/20 ,  C07H13/04 ,  C07B59/00

CPC classification number: C08F212/14 ,  A61B5/1405 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1514 ,  B01D15/363 ,  B01J19/0093 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/328 ,  B01J2219/00831 ,  B01J2219/00844 ,  B01J2219/00846 ,  B01J2219/00905 ,  B01J2219/00918 ,  B01J2219/00936 ,  B01J2219/00943 ,  B01J2220/82 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0883 ,  C07B59/005 ,  C07H13/04 ,  C08F236/20

Abstract: The present disclosure relates to the novel multistep procedure for preparation of polymer monoliths for use in solvent exchange, such as methods to exchange and activate fluoride ions on a flow through microfluidic chip for subsequent chemical synthesis. Methods according to the present disclosure include the application of such microfluidic platforms for rapid F18 radiosynthesis on a flow through microfluidic chip with high efficiency, followed by a subsequent nucleophilic fluorination reaction. Various other methods of exchanging and activating fluoride ions on a flow through microfluidic chip are also disclosed. Methods incorporating features of the present invention can be applicable to any flow through microfluidic device in any field, such as radiosyntheses, chemical syntheses, concentration of ions for environmental analyses and sample preparation such as concentrating minute amounts of analyte to improve the downstream detection.

Abstract translation: 本公开涉及用于制备用于溶剂交换的聚合物整料的新型多步骤方法，例如在通过微流体芯片的流动上交换和活化氟离子以用于随后的化学合成的方法。 根据本公开的方法包括将这种微流体平台用于快速F18放射合成在高效率流过微流控芯片的流体上，随后进行亲核氟化反应。 还公开了在流过微流体芯片的流动上交换和激活氟离子的各种其它方法。 结合本发明的特征的方法可以适用于任何领域中的任何流过微流体装置的流体，例如放射合成，化学合成，用于环境分析的离子浓度和样品制备，例如浓缩微量分析物以改善下游检测。

公开(公告)号：US20140316130A1

公开(公告)日：2014-10-23

申请号：US14253049

申请日：2014-04-15

Applicant: HAMMERSMITH IMANET LIMITED

Inventor： FRANK BRADY ,  SAJINDER KAUR LUTHRA ,  JAMES MILLAR GILLIES ,  NICHOLAS TOBY JEFFREY

IPC: C07H5/02 ,  C07D401/04 ,  C07D223/16 ,  C07C211/48 ,  C07C229/36

CPC classification number: C07H5/02 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00952 ,  B01L3/5027 ,  B01L3/502715 ,  C07B59/00 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07C211/48 ,  C07C229/36 ,  C07D223/16 ,  C07D401/04

Abstract: This invention relates to the miniaturisation of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).

Abstract translation: 本发明涉及在微加工装置上放射合成的小型化，特别是涉及使用微加工装置进行放射性合成，分离和分析用于正电子发射断层扫描（PET）的放射性示踪剂。

公开(公告)号：US20130130309A1

公开(公告)日：2013-05-23

申请号：US13446334

申请日：2012-04-13

Applicant: Ronald Nutt ,  Antony M. Giamis ,  Aaron McFarland

Inventor： Ronald Nutt ,  Antony M. Giamis ,  Aaron McFarland

IPC: G01N30/74 ,  G01N33/60

CPC classification number: G01N30/74 ,  A61K51/0491 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  G01N30/88 ,  G01N33/60 ,  G01N2030/77 ,  G01N2030/8872

Abstract: HPLC-based quality control systems to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an integrated PET biomarker radiopharmaceutical production system, the present general inventive concept permits a manufacturer to produce product and conduct quality control tests with lower per dose costs.

Abstract translation: 基于HPLC的质量控制系统，在合成后不久就对放射性药物溶液进行质量控制测试。 基于HPLC的质量控制系统有效利用样品体积，并与各种放射性同位素和放射性药物化合物相容。 在几个实施例中，基于HPLC的质量控制系统的自动化性质允许快速进行质量控制测试并且对用户工作流程的影响最小。 当作为PET生物标志物整合放射性药物生产系统的一部分使用时，本发明总体上允许制造商生产产品并以较低的每剂量成本进行质量控制测试。

公开(公告)号：US08378163B2

公开(公告)日：2013-02-19

申请号：US11088692

申请日：2005-03-23

Applicant: Junko Ida ,  Francis P. Daly ,  Terry Mazanec ,  Barry L. Yang ,  Richard Long

Inventor： Junko Ida ,  Francis P. Daly ,  Terry Mazanec ,  Barry L. Yang ,  Richard Long

IPC: C07C5/48

CPC classification number: B01J19/0093 ,  B01J23/42 ,  B01J23/6567 ,  B01J35/0006 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0215 ,  B01J37/0225 ,  B01J37/0226 ,  B01J37/0238 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00995 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/086 ,  B01L2400/088 ,  C01B3/384 ,  C01B3/386 ,  C01B2203/0233 ,  C01B2203/0261 ,  C01B2203/0811 ,  C01B2203/0844 ,  C01B2203/1041 ,  C01B2203/107 ,  C01B2203/1241 ,  C01B2203/141 ,  C01B2203/82 ,  F23C13/00 ,  F23C2900/03001 ,  Y02P20/52

Abstract: The invention describes catalysts, methods of making catalysts, methods of making a microchannel reactor, and methods of conducting chemical reactions. It has been discovered that superior performance can be obtained from a catalyst formed by directly depositing a catalytic material onto a (low surface area) thermally-grown alumina layer. Improved methods of conducting oxidative dehydrogenations are also described.

Abstract translation: 本发明描述了催化剂，制备催化剂的方法，制备微通道反应器的方法和进行化学反应的方法。 已经发现，通过将催化材料直接沉积到（低表面积）热生长氧化铝层上形成的催化剂可以获得优异的性能。 还描述了改进的进行氧化脱氢的方法。