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公开(公告)号：US20200158680A1
公开(公告)日：2020-05-21
申请号：US16743101
申请日：2020-01-15
Applicant: University Of Cincinnati
Inventor： Joshua A. Hagen , Jason C. Heikenfeld , Ian Papautsky , Linlin Hou , Rajesh Naik , Nancy Kelley - Loughnane , Morley Stone , John Busbee , Xiao Wang
IPC: G01N27/327 , G01N27/414 , A61B5/145 , B01L3/00 , A61B5/1477 , A61B10/00 , A61B5/00
Abstract: Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector 10 and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor 50, or on a continuous basis using a chemical, field effect transducer 98.
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公开(公告)号：US09987632B2
公开(公告)日：2018-06-05
申请号：US14376450
申请日：2013-02-01
Applicant: University of Cincinnati
Inventor： Ian Papautsky , Jian Zhou
CPC classification number: B01L3/502761 , B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01J2219/00905 , B01J2219/00984 , B01L3/502753 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B03B5/62 , B07B7/00 , Y10T137/0318
Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.
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公开(公告)号：US20220412914A1
公开(公告)日：2022-12-29
申请号：US17823286
申请日：2022-08-30
Applicant: University Of Cincinnati
Inventor： Joshua A. Hagen , Jason C. Heikenfeld , Ian Papautsky , Linlin Hou , Rajesh Naik , Nancy Kelley-Loughnan , Morley O. Stone , John Busbee , Xiao Wang
IPC: G01N27/327 , A61B5/00 , A61B10/00 , A61B5/145 , A61B5/1477 , B01L3/00 , G01N27/414
Abstract: Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.
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公开(公告)号：US11460430B2
公开(公告)日：2022-10-04
申请号：US14388416
申请日：2013-04-03
Applicant: University of Cincinnati
Inventor： Joshua A. Hagen , Jason Charles Heikenfeld , Ian Papautsky , Linlin Hou , Rajesh Naik , Nancy Kelley-Loughnane , Morley O. Stone , John Busbee , Xiao Wang
IPC: G01N27/327 , A61B5/00 , A61B10/00 , A61B5/145 , A61B5/1477 , B01L3/00 , G01N27/414
Abstract: Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.
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公开(公告)号：US10512913B2
公开(公告)日：2019-12-24
申请号：US15983815
申请日：2018-05-18
Applicant: University Of Cincinnati
Inventor： Ian Papautsky , Jian Zhou
Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.
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Patent Agency Ranking
公开(公告)号：US20150055134A1
公开(公告)日：2015-02-26
申请号：US14376324
申请日：2013-02-04
Applicant: University of Cincinnati , United States of America as Represented by the Secretary of the Air Force
Inventor： Ian Papautsky , Li Shen , Rajesh Naik , Joshua Hagen , Morley Stone
CPC classification number: G01N21/25 , G01J3/46 , G01N21/278 , G01N21/293 , G01N21/78 , G01N2201/061 , G01N2201/127 , G01N2201/13
Abstract: Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in the image, converting the intensity data for at least one of the red channel, the green channel, or the blue channel to a first data point, recalling a predetermined standardized curve, comparing the first data point with the standardized curve, and identifying the value for the assay parameter from the standardized curve.
Abstract translation: 本文描述了一种用于分析比色测定法的方法，系统和计算机程序，其包括获得测定图像，可选地校正图像中的环境光照条件，转换红色通道，绿色通道中的至少一个的强度数据 或蓝色通道移动到第一数据点，回忆预定的标准化曲线，将第一数据点与标准化曲线进行比较，并从标准化曲线识别测定参数的值。
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公开(公告)号：US20140374324A1
公开(公告)日：2014-12-25
申请号：US14376450
申请日：2013-02-01
Applicant: University of Cincinnati
Inventor： Ian Papautsky , Jian Zhou
CPC classification number: B01L3/502761 , B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01J2219/00905 , B01J2219/00984 , B01L3/502753 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B03B5/62 , B07B7/00 , Y10T137/0318
Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.
Abstract translation: 一种从流体的一部分分离多个颗粒（14）的方法，包括将多个颗粒（14）引导到微通道（12）中。 颗粒（14）的第一部分（16）被聚焦到微通道（12）中的平衡位置。 聚焦的第一部分（16）被引导到与平衡位置对准的第一出口（18）中。 一部分流体被引导到一个或多个出口（20,22）中。 一种用于从流体的一部分分离多个颗粒（14）的微流体装置（10），包括具有第一长宽比和长度L的微通道（12），从而将引导到其中的颗粒（14）聚焦到平衡位置 在所述微通道中，其中所述颗粒（14）的至少第一部分（16）以与所述微通道（12）的开始处的距离X聚焦。 在第一部分（16）聚焦到微通道（12）中的平衡位置之后，设置在距离X之后并与平衡位置对准的第一出口（18）以接收至少第一部分（16） 。 至少第二出口（20），用于在第二部分聚焦到平衡位置之前接收颗粒（14）的第二部分。
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公开(公告)号：US20180264473A1
公开(公告)日：2018-09-20
申请号：US15983815
申请日：2018-05-18
Applicant: University Of Cincinnati
Inventor： Ian Papautsky , Jian Zhou
CPC classification number: B01L3/502761 , B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01J2219/00905 , B01J2219/00984 , B01L3/502753 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B03B5/62 , B07B7/00 , Y10T137/0318
Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12). A first outlet (18) disposed after distance X and aligned with the equilibrium position to receive at least the first portion (16) of the particles (14) after the first portion (16) focuses into an equilibrium position in the microchannel (12). At least a second outlet (20) for receiving a second portion of the particles (14) before the second portion focuses into an equilibrium position.
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公开(公告)号：US09506855B2
公开(公告)日：2016-11-29
申请号：US14376324
申请日：2013-02-04
Applicant: University of Cincinnati , The United States of America as Represented by the Secretary of the Air Force
Inventor： Ian Papautsky , Li Shen , Joshua Hagen , Morley Stone
CPC classification number: G01N21/25 , G01J3/46 , G01N21/278 , G01N21/293 , G01N21/78 , G01N2201/061 , G01N2201/127 , G01N2201/13
Abstract: Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in the image, converting the intensity data for at least one of the red channel, the green channel, or the blue channel to a first data point, recalling a predetermined standardized curve, comparing the first data point with the standardized curve, and identifying the value for the assay parameter from the standardized curve.
Abstract translation: 本文描述了一种用于分析比色测定法的方法，系统和计算机程序，其包括获得测定图像，可选地校正图像中的环境光照条件，转换红色通道，绿色通道中的至少一个的强度数据 或蓝色通道移动到第一数据点，回忆预定的标准化曲线，将第一数据点与标准化曲线进行比较，并从标准化曲线识别测定参数的值。
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公开(公告)号：US20150057515A1
公开(公告)日：2015-02-26
申请号：US14388416
申请日：2013-04-03
Applicant: University of Cincinnati
Inventor： Joshua A Hagen , Jason C. Heikenfeld , Ian Papautsky , Linlin Hou , Rajesh Naik , Nancy Kelly-Loughnane , Morley Stone , John Busbee , Xiao Wang
IPC: G01N27/327 , G01N27/414 , A61B5/145
CPC classification number: G01N27/3273 , A61B5/0002 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1477 , A61B5/681 , A61B10/0064 , A61B10/0096 , B01L3/5023 , B01L2200/0621 , B01L2300/022 , B01L2300/023 , B01L2300/0645 , B01L2300/069 , B01L2300/0803 , B01L2300/0864 , B01L2400/0406 , B01L2400/0677 , B01L2400/086 , G01N27/4145
Abstract: Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.
Abstract translation: 血液中可能发现的生物化学物质是通过收集汗液并确定所选择的化学物质在汗液中的浓度或含义来测量的。 可以使用基于时间的间隔收集器收集汗液，并使用外部设备进行分析。 也可以使用灵活的化学电容器，或者使用化学的场效应传感器在连续的基础上一次收集。
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