公开(公告)号：US10717964B2

公开(公告)日：2020-07-21

申请号：US16042257

申请日：2018-07-23

申请人： University of Delaware

发明人： Eleftherios T. Papoutsakis ,  Sergios Nicolaou ,  Alan Fast ,  Vasiliki Falara ,  Robert Kyle Bennett ,  William Brian Whitaker ,  Nicholas Richard Sandoval ,  Jacqueline Gonzalez ,  Maciek Antoniewicz

IPC分类号： C12N1/32 ,  C12P7/16 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12N9/04 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70

摘要： A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.

公开(公告)号：US10059920B2

公开(公告)日：2018-08-28

申请号：US15112364

申请日：2015-01-09

申请人： University of Delaware

发明人： Eleftherios T. Papoutsakis ,  Sergios Nicolaou ,  Alan Fast ,  Vasiliki Falara ,  Robert Kyle Bennett ,  William Brian Whitaker ,  Nicholas Richard Sandoval ,  Jacqueline Gonzalez ,  Maciek Antoniewicz

IPC分类号： C12N1/32 ,  C12P7/16 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12N9/04 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70

CPC分类号： C12N1/32 ,  C12N9/0006 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70 ,  C12P7/16 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/625 ,  Y02E50/10

摘要： A non-naturally occurring microbe capable of growing in a medium comprising methanol is provided. The methanol contributes to a significant percentage (e.g., at least 40%) of the carbon source for the non-naturally occurring microbe, which expresses heterologous methanol dehydrogenase (MDH) and heterologous ribulose monophosphate (RuMP) pathway enzymes. Methods for producing liquid fuels and chemicals by the non-naturally occurring microbe and methods for preparing the non-naturally occurring microbe are also provided.