公开(公告)号：US20240181444A1

公开(公告)日：2024-06-06

申请号：US18577356

申请日：2022-09-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Zhonghui Hugh Fan ,  Carlos Manzanas ,  Morteza Alipanahrostami ,  John A. Lednicky ,  Chang-Yu Wu

IPC: B01L3/00 ,  C12Q1/6844

CPC classification number: B01L3/5025 ,  C12Q1/6844 ,  B01L2200/16 ,  B01L2300/0829 ,  B01L2300/1827 ,  B01L2400/0616

Abstract: Provided are multiplex devices for nucleic acid detection and methods for nucleic acid detection. The device includes at least two parallel buffer units comprised of buffer wells arranged in a row. The buffer units are connected to form a multiplex device. A mixing unit is slides along a bottom of each buffer unit to align with each buffer well in turn. When the mixing unit is aligned with a buffer well, a ball valve releases buffer from the buffer well into the mixing well. The device includes a detection unit removably coupled to the bottom of each mixing unit to receive fluids from the mixing well.

公开(公告)号：US20250043231A1

公开(公告)日：2025-02-06

申请号：US18774053

申请日：2024-07-16

Applicant: University of Florida Research Foundation, Inc.

Inventor： Zhonghui Hugh Fan ,  Xiao Jiang ,  Trevor B. Tilly ,  John Lednicky ,  Chang-Yu Wu

IPC: C12M1/34 ,  B01L3/00 ,  C12M1/36 ,  C12M3/00 ,  G01N33/569

Abstract: An apparatus and method are provided for performing detection of microorganisms (e.g., viruses) with high sensitivity. The apparatus and method are well suited for point-of-care (POC) testing in resource-limited regions and are capable of being operated with very little manual intervention and without the need for lab equipment. A variety of viruses can be detected with high sensitivity, including, for example, coronaviruses, Zika virus and flu viruses.

公开(公告)号：US12071610B2

公开(公告)日：2024-08-27

申请号：US17140696

申请日：2021-01-04

Applicant: University of Florida Research Foundation, Inc.

Inventor： Zhonghui Hugh Fan ,  Xiao Jiang ,  Trevor B. Tilly ,  John Lednicky ,  Chang-Yu Wu

IPC: C12M1/34 ,  B01L3/00 ,  C12M1/36 ,  C12M3/00 ,  G01N33/569

CPC classification number: C12M41/46 ,  B01L3/527 ,  C12M23/44 ,  C12M41/48 ,  G01N33/56916 ,  G01N33/56983 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2400/0616

Abstract: An apparatus and method are provided for performing detection of microorganisms (e.g., viruses) with high sensitivity. The apparatus and method are well suited for point-of-care (POC) testing in resource-limited regions and are capable of being operated with very little manual intervention and without the need for lab equipment. A variety of viruses can be detected with high sensitivity, including, for example, coronaviruses, Zika virus and flu viruses.

公开(公告)号：US11845997B2

公开(公告)日：2023-12-19

申请号：US17104525

申请日：2020-11-25

Applicant: University of Florida Research Foundation, Inc.

Inventor： Chang-Yu Wu ,  Xiao Jiang ,  Maohua Pan ,  John Lednicky ,  Alexandros Demetrios Theodore ,  Zhonghui Hugh Fan ,  Nima Afshar Mohajer

IPC: C12Q1/70 ,  G01N33/569

CPC classification number: C12Q1/70 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2333/165

Abstract: Described herein are bioaerosol detection systems and methods of use. In embodiments of bioaerosol detection systems and methods of use as described herein, systems and methods detect one or more coronaviruses and/or one or more influenza strains. In embodiments, coronaviruses according to systems and methods as described herein are SARS-CoV-2 coronavirus. In embodiments, influenza strains and/or particles according to the present disclosure are H1N1 influenza.

公开(公告)号：US10859473B2

公开(公告)日：2020-12-08

申请号：US16089099

申请日：2017-04-06

Applicant: THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Chang-Yu Wu ,  Xiao Jiang ,  Maohua Pan ,  John Lednicky ,  Alexandros Demetrios Theodore ,  Zhonghui Hugh Fan ,  Nima Afshar Mohajer

IPC: C12Q1/70 ,  G01N33/569 ,  G01N1/22 ,  G01N33/543

Abstract: Described herein are bioaerosol detection systems and methods of use.

公开(公告)号：US20210230533A1

公开(公告)日：2021-07-29

申请号：US17140696

申请日：2021-01-04

Applicant: University of Florida Research Foundation, Inc.

Inventor： Zhonghui Hugh Fan ,  Xiao Jiang ,  Trevor B. Tilly ,  John Lednicky ,  Chang-Yu Wu

IPC: C12M1/34 ,  C12M3/00 ,  C12M1/36 ,  G01N33/569

Abstract: An apparatus and method are provided for performing detection of microorganisms (e.g., viruses) with high sensitivity. The apparatus and method are well suited for point-of-care (POC) testing in resource-limited regions and are capable of being operated with very little manual intervention and without the need for lab equipment. A variety of viruses can be detected with high sensitivity, including, for example, coronaviruses, Zika virus and flu viruses.