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    COMPOSITIONS AND METHODS FOR REDUCING OXIDATIVE DAMAGE
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR REDUCING OXIDATIVE DAMAGE 有权
    用于减少氧化损伤的组合物和方法

    公开(公告)号：US20150290230A1

    公开(公告)日：2015-10-15

    申请号：US14646660

    申请日：2013-11-21

    申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC

    发明人： Tongalp H. Tezel ,  Andrea S. Gobin ,  Martin G. O'Toole

    IPC分类号： A61K31/7016 ,  A61K47/38 ,  A61K9/00 ,  A61K47/32 ,  C08L1/28 ,  C08L33/14

    CPC分类号： A61K31/7016 ,  A61F9/00 ,  A61K9/0048 ,  A61K9/0051 ,  A61K47/32 ,  A61K47/38 ,  C08L1/284 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  C08L33/14 ,  C08L2205/05 ,  C08L71/02

    摘要： Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

    摘要翻译： 提供聚合物组合物，其包括聚（乙二醇），粘弹性聚合物和抗氧化剂，其中聚合形式的组合物具有约1.30至约1.40的折射率。 还提供了合成组合物的方法，包括加热一定量的水的步骤; 向水中加入缓冲剂形成缓冲溶液; 将聚（乙二醇）和粘弹性聚合物混合到缓冲溶液中以形成反应性混合物; 向反应混合物中加入多种抗氧化剂颗粒; 并从反应混合物中除去悬浮气泡。 进一步提供了防止受试者的眼晶状体的氧化损伤的方法，包括将前述聚合物组合物给予受试者的眼晶状体。

    Compositions and Methods for Reducing Oxidative Damage
    5.
    发明申请
    Compositions and Methods for Reducing Oxidative Damage 审中-公开

    公开(公告)号：US20190350956A1

    公开(公告)日：2019-11-21

    申请号：US16227680

    申请日：2018-12-20

    申请人： University of Louisville Research Foundation, Inc.

    发明人： Tongalp H. Tezel ,  Andrea S. Gobin ,  Martin G. O'Toole

    IPC分类号： A61K31/7016 ,  A61K9/00 ,  C08L1/28 ,  C08L33/14 ,  A61K47/38 ,  A61K47/32 ,  C08L5/10 ,  C08L5/08 ,  C08L5/02

    摘要： Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

    Compositions and Methods for Reducing Oxidative Damage
    8.
    发明申请
    Compositions and Methods for Reducing Oxidative Damage 有权

    公开(公告)号：US20220110959A1

    公开(公告)日：2022-04-14

    申请号：US17356082

    申请日：2021-06-23

    申请人： University of Louisville Research Foundation, Inc.

    发明人： Tongalp H. Tezel ,  Andrea S. Gobin ,  Martin G. O'Toole

    IPC分类号： A61K31/7016 ,  C08L1/28 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  A61K9/00 ,  A61K47/32 ,  A61K47/38 ,  C08L33/14

    摘要： Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

    Compositions and methods for reducing oxidative damage
    9.
    发明授权
    Compositions and methods for reducing oxidative damage 有权
    减少氧化损伤的组合物和方法

    公开(公告)号：US09555054B2

    公开(公告)日：2017-01-31

    申请号：US14646660

    申请日：2013-11-21

    申请人： University of Louisville Research Foundation, Inc.

    发明人： Tongalp H. Tezel ,  Andrea S. Gobin ,  Martin G. O'Toole

    IPC分类号： C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  A61K31/7016 ,  C08L1/28 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  A61K9/00 ,  A61K47/32 ,  A61K47/38 ,  C08L33/14 ,  A61F9/00

    CPC分类号： A61K31/7016 ,  A61F9/00 ,  A61K9/0048 ,  A61K9/0051 ,  A61K47/32 ,  A61K47/38 ,  C08L1/284 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  C08L33/14 ,  C08L2205/05 ,  C08L71/02

    摘要： Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

    摘要翻译： 提供聚合物组合物，其包括聚（乙二醇），粘弹性聚合物和抗氧化剂，其中聚合形式的组合物具有约1.30至约1.40的折射率。 还提供了合成组合物的方法，包括加热一定量的水的步骤; 向水中加入缓冲剂形成缓冲溶液; 将聚（乙二醇）和粘弹性聚合物混合到缓冲溶液中以形成反应性混合物; 向反应混合物中加入多种抗氧化剂颗粒; 并从反应混合物中除去悬浮气泡。 进一步提供了防止受试者的眼晶状体的氧化损伤的方法，包括将前述聚合物组合物给予受试者的眼晶状体。