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公开(公告)号：US10467755B2
公开(公告)日：2019-11-05
申请号：US14786366
申请日：2014-04-23
Applicant: UNIVERSITY OF MAINE SYSTEM BOARD OF TRUSTEES
Inventor： Andre Khalil , Kendra Ann Batchelder
Abstract: The present invention provides, among other things, methods of identifying cancerous or pre-cancerous tissue including providing a first region of tissue from a subject, calculating a roughness exponent for the first region of tissue, and comparing the roughness exponent of the first region of tissue to 0.5, wherein a difference of less than 0.2 between the roughness exponent of the first region of tissue and 0.5 indicates that the tissue is cancerous or pre-cancerous. Additionally, the present invention provides methods including providing a first view of a region of tissue, providing a second view of a region of tissue, calculating a first fractal dimension for the first view of the region of tissue, and calculating a second fractal dimension for the second view of the region of tissue, wherein if the fractal dimension of at least one of the first fractal dimension and the second fractal dimension is in the fractal zone, the region of tissue is considered cancerous. Also provided are systems for performing these assessments.
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公开(公告)号：US20160055636A1
公开(公告)日：2016-02-25
申请号：US14786366
申请日：2014-04-23
Applicant: UNIVERSITY OF MAINE SYSTEM BOARD OF TRUSTEES
Inventor： Andre Khalil , Kendra Ann Batchelder
CPC classification number: G06T7/0016 , A61B5/08 , A61B5/201 , A61B5/4064 , A61B5/4244 , A61B5/425 , A61B5/4325 , A61B5/444 , A61B5/7257 , A61B5/726 , A61B6/502 , A61B2576/00 , G06T7/48 , G06T2207/20021 , G06T2207/20064 , G06T2207/30024
Abstract: The present invention provides, among other things, methods of identifying cancerous or pre-cancerous tissue including providing a first region of tissue from a subject, calculating a roughness exponent for the first region of tissue, and comparing the roughness exponent of the first region of tissue to 0.5, wherein a difference of less than 0.2 between the roughness exponent of the first region of tissue and 0.5 indicates that the tissue is cancerous or pre-cancerous. Additionally, the present invention provides methods including providing a first view of a region of tissue, providing a second view of a region of tissue, calculating a first fractal dimension for the first view of the region of tissue, and calculating a second fractal dimension for the second view of the region of tissue, wherein if the fractal dimension of at least one of the first fractal dimension and the second fractal dimension is in the fractal zone, the region of tissue is considered cancerous. Also provided are systems for performing these assessments.
Abstract translation: 本发明尤其提供了鉴定癌症或癌前组织的方法，包括提供来自受试者的组织的第一区域，计算组织的第一区域的粗糙度指数，并且比较第一区域的粗糙度指数 组织为0.5，其中在组织的第一区域的粗糙度指数之间小于0.2的差异指示组织是癌性的或癌前的。 另外，本发明提供了包括提供组织区域的第一视图，提供组织区域的第二视图，计算组织区域的第一视图的第一分形维数以及计算第二分形维数的方法， 组织区域的第二视图，其中如果第一分形维数和第二分形维数中的至少一个的分形维数在分形区域中，则组织区域被认为是癌性的。 还提供了执行这些评估的系统。
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公开(公告)号：US10769790B2
公开(公告)日：2020-09-08
申请号：US16577238
申请日：2019-09-20
Applicant: University of Maine System Board of Trustees
Inventor： Andre Khalil , Kendra Ann Batchelder
Abstract: The present invention provides, among other things, methods of identifying cancerous or pre-cancerous tissue including providing a first region of tissue from a subject, calculating a roughness exponent for the first region of tissue, and comparing the roughness exponent of the first region of tissue to 0.5, wherein a difference of less than 0.2 between the roughness exponent of the first region of tissue and 0.5 indicates that the tissue is cancerous or pre-cancerous. Additionally, the present invention provides methods including providing a first view of a region of tissue, providing a second view of a region of tissue, calculating a first fractal dimension for the first view of the region of tissue, and calculating a second fractal dimension for the second view of the region of tissue, wherein if the fractal dimension of at least one of the first fractal dimension and the second fractal dimension is in the fractal zone, the region of tissue is considered cancerous. Also provided are systems for performing these assessments.
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公开(公告)号：US20200082532A1
公开(公告)日：2020-03-12
申请号：US16577238
申请日：2019-09-20
Applicant: University of Maine System Board of Trustees
Inventor： Andre Khalil , Kendra Ann Batchelder
Abstract: The present invention provides, among other things, methods of identifying cancerous or pre-cancerous tissue including providing a first region of tissue from a subject, calculating a roughness exponent for the first region of tissue, and comparing the roughness exponent of the first region of tissue to 0.5, wherein a difference of less than 0.2 between the roughness exponent of the first region of tissue and 0.5 indicates that the tissue is cancerous or pre-cancerous. Additionally, the present invention provides methods including providing a first view of a region of tissue, providing a second view of a region of tissue, calculating a first fractal dimension for the first view of the region of tissue, and calculating a second fractal dimension for the second view of the region of tissue, wherein if the fractal dimension of at least one of the first fractal dimension and the second fractal dimension is in the fractal zone, the region of tissue is considered cancerous. Also provided are systems for performing these assessments.
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