公开(公告)号：US20220067105A1

公开(公告)日：2022-03-03

申请号：US17003661

申请日：2020-08-26

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Yoram Vodovotz ,  Fayten El-Dehaibi ,  Qi Mi

IPC分类号： G06F16/903 ,  G16H10/60 ,  G16B50/30 ,  G16B20/20

摘要： This document describes a search engine that accepts as input different types of data files and conditions for search parameters, including both single and multiple time points, concatenates these data, and outputs data from the different types of files that satisfies the specified search conditions. In one aspect, a method includes receiving a selection of a multiple input data files that each include data on which a search is to be performed. The input data files include different types of data files having different data formats. An in-memory data structure that includes the data of the input data files arranged in a common format is generated. For each of one or more search parameters, data indicating a condition for the search parameter is received. A set of data that satisfies the condition of each of the one or more search parameters is identified in the in-memory data structure.

公开(公告)号：US09981048B2

公开(公告)日：2018-05-29

申请号：US14177928

申请日：2014-02-11

申请人： University of Pittsburgh—of the Commonwealth System of Higher Education

发明人： Ira Jacob Fox ,  Aaron W. Bell ,  Taichiro N. Nishikawa ,  Alejandro Soto-Gutierrez ,  Yoram Vodovotz

IPC分类号： A61K48/00 ,  A61K31/343 ,  C07K14/47 ,  A61K45/06 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  C12N15/86

CPC分类号： A61K48/005 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61K31/343 ,  A61K45/06 ,  C07K14/4702 ,  C12N15/86 ,  C12N2750/14141 ,  C12N2750/14171 ,  A61K2300/00

摘要： The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an animal model of cirrhosis, resulting in improvement in hepatic function, treatment of cirrhosis, and prolonged survival.

公开(公告)号：US11854701B2

公开(公告)日：2023-12-26

申请号：US17473726

申请日：2021-09-13

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Gregory M. Constantine ,  Timothy Billiar ,  Qi Mi ,  Rami Namas ,  Lukas Schimunek ,  Yoram Vodovotz

IPC分类号： G16H50/30 ,  G16H20/10 ,  G16H50/20 ,  G16H50/70 ,  G16B20/20 ,  G16B40/00 ,  G16B40/30 ,  G16H70/40

CPC分类号： G16H50/30 ,  G16B20/20 ,  G16B40/00 ,  G16B40/30 ,  G16H20/10 ,  G16H50/20 ,  G16H50/70 ,  G16H70/40

摘要： Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.

公开(公告)号：US11004543B2

公开(公告)日：2021-05-11

申请号：US15223367

申请日：2016-07-29

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Joyeeta Dutta-Moscato ,  Liang-I Kang ,  Qi Mi ,  Kari Nejak-Bowen ,  Yoram Vodovotz

IPC分类号： G16B50/00 ,  G16H50/50

摘要： Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.

公开(公告)号：US10137236B2

公开(公告)日：2018-11-27

申请号：US14301734

申请日：2014-06-11

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Yoram Vodovotz ,  Alexey Solovyev ,  David Okonkwo ,  Maxim Mikheev ,  Qi Mi ,  Jorg Gerlach ,  Gregory M Constantine

IPC分类号： A61M1/34 ,  A61M1/00 ,  B01D63/02 ,  A61M1/36

摘要： A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

公开(公告)号：US20220215963A1

公开(公告)日：2022-07-07

申请号：US17473726

申请日：2021-09-13

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Gregory M. Constantine ,  Timothy Billiar ,  Qi Mi ,  Rami Namas ,  Lukas Schimunek ,  Yoram Vodovotz

IPC分类号： G16H50/30 ,  G16H20/10 ,  G16H50/20 ,  G16H50/70 ,  G16B20/20 ,  G16B40/00 ,  G16B40/30

摘要： Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.

公开(公告)号：US20180322956A1

公开(公告)日：2018-11-08

申请号：US15971519

申请日：2018-05-04

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Gregory M. Constantine ,  Timothy Billiar ,  Qi Mi ,  Yoram Vodovotz ,  Rami Namas ,  Lukas Schimunek

IPC分类号： G16H50/30 ,  G16H50/20 ,  G16H20/10

CPC分类号： G16H50/30 ,  G16H20/10 ,  G16H50/20 ,  G16H70/40

摘要： Provided herein are methods for segregating trauma, e.g., blunt trauma, patients into different cohorts based on risk of multiple organ dysfunction syndrome using patient data obtained within a short time window following injury. The methods are useful in providing treatment to trauma patients, and for separating trauma patients into cohorts.

公开(公告)号：US20150104807A1

公开(公告)日：2015-04-16

申请号：US14463481

申请日：2014-08-19

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： CHANRASHEKHAR R. GANDHI ,  Yoram Vodovotz

IPC分类号： G01N33/573

CPC分类号： G01N33/573 ,  A01K2207/20 ,  A01K2207/30 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K31/00 ,  C07K16/18 ,  C07K16/22 ,  C12N15/113 ,  C12N2310/11 ,  G01N33/6893 ,  G01N2333/71 ,  G01N2333/90212 ,  G01N2800/24 ,  G01N2800/26 ,  G01N2800/7095

摘要： The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver Regeneration (“ALR”) is an early marker of these conditions. Accordingly, in other embodiments, the present invention provides for a method of treating sepsis, traumatic/hemorrhagic shock and inflammation by inhibiting ALR.

摘要翻译： 本发明提供了用于检测受试者中败血症，创伤/出血或炎症的方法和试剂盒。 至少部分基于发现肝脏再生增强剂（“ALR”）是这些病症的早期标志。 因此，在其它实施方案中，本发明提供了通过抑制ALR来治疗败血症，创伤/出血性休克和炎症的方法。

公开(公告)号：US11224685B2

公开(公告)日：2022-01-18

申请号：US16156277

申请日：2018-10-10

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Yoram Vodovotz ,  Alexey Solovyev ,  David Okonkwo ,  Maxim Mikheev ,  Qi Mi ,  Jorg Gerlach ,  Gregory M. Constantine

IPC分类号： A61M1/34 ,  A61M1/00 ,  A61M1/36 ,  B01D63/02

摘要： A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

公开(公告)号：US20170083683A1

公开(公告)日：2017-03-23

申请号：US15223367

申请日：2016-07-29

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Joyeeta Dutta-Moscato ,  Liang-I Kang ,  Qi Mi ,  Kari Nejak-Bowen ,  Yoram Vodovotz

IPC分类号： G06F19/00 ,  G06F19/28

CPC分类号： G16B50/00 ,  G16H50/50

摘要： Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.