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公开(公告)号：US20220409166A1
公开(公告)日：2022-12-29
申请号：US17929080
申请日：2022-09-01
发明人： Kang Kim , Ahmed M. Mahmoud , Debaditya Dutta
摘要： A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the target area using an ultrasound scanner, and quantifying the amount of fat in the targeted area based on the thermal strain imaging. In some embodiments, the thermal strain imaging is performed using high-resolution, phase-sensitive speckle tracking to differentiate between fat-based tissue and water-based tissue.
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2.发明授权公开(公告)号：US11529122B2
公开(公告)日：2022-12-20
申请号：US16726089
申请日：2019-12-23
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , The Regents of the University of Michigan
发明人： Kang Kim , Jingping Xu , Jonathan M Rubin
摘要： A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.
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公开(公告)号：US10299685B2
公开(公告)日：2019-05-28
申请号：US14366666
申请日：2012-12-21
发明人： Kang Kim , Zhaohui Wang , Seung Han Ha
摘要： Photoacoustic probes include reflective surfaces situated to redirect scattered or reflected optical radiation from a specimen surface back to the specimen. A reflective coating can reflect probe radiation while transmitting visible radiation so that a technician can view the specimen. One or more optical fibers and acoustic transducers can be secured to a lens or other substrate on which the reflective surface is defined. The light collector is configured to block scattered light so that an operator and a subject are not exposed to the scattered light.
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4.发明申请METHOD AND APPARATUS TO DETECT LIPID CONTENTS IN TISSUES USING ULTRASOUND 审中-公开使用超声波检测组织中的脂质含量的方法和装置公开(公告)号：US20150327835A1
公开(公告)日：2015-11-19
申请号：US14409378
申请日：2013-07-03
发明人： Kang Kim , Ahmed M. Mahmoud , Debaditya Dutta
CPC分类号： A61B8/08 , A61B5/0095 , A61B5/015 , A61B5/4872 , A61B8/4416 , A61B8/48 , A61B8/485 , A61B8/5223 , A61B8/543
摘要： A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the target area using an ultrasound scanner, and quantifying the amount of fat in the targeted area based on the thermal strain imaging. In some embodiments, the thermal strain imaging is performed using high-resolution, phase-sensitive speckle tracking to differentiate between fat-based tissue and water-based tissue.
摘要翻译： 用于定量体内包含在受试者的肝脏或其他组织中的脂肪量的方法包括改变受试者的目标区域的温度，使用超声波扫描仪成像目标区域的热应变，并且定量脂肪的量 在目标区域基于热应变成像。 在一些实施例中，使用高分辨率，相敏斑点跟踪来进行热应变成像，以区分基于脂肪的组织和水基组织。
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公开(公告)号：US11464479B2
公开(公告)日：2022-10-11
申请号：US16430315
申请日：2019-06-03
发明人： Kang Kim , Ahmed M. Mahmoud , Debaditya Dutta
摘要： A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the target area using an ultrasound scanner, and quantifying the amount of fat in the targeted area based on the thermal strain imaging. In some embodiments, the thermal strain imaging is performed using high-resolution, phase-sensitive speckle tracking to differentiate between fat-based tissue and water-based tissue.
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6.发明申请公开(公告)号：US20170100099A1
公开(公告)日：2017-04-13
申请号：US15389036
申请日：2016-12-22
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , The Regents of the University of Michigan
发明人： Kang Kim , Jingping Xu , Jonathan M. Rubin
CPC分类号： A61B8/485 , A61B8/08 , A61B8/085 , A61B8/0858 , A61B8/4281 , A61B8/4483 , A61B8/461 , A61B8/5223 , G01N29/0654 , G01N29/07 , G01N2291/02475 , G01N2291/0422
摘要： A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.
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7.发明申请公开(公告)号：US20200146654A1
公开(公告)日：2020-05-14
申请号：US16726089
申请日：2019-12-23
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , The Regents of the University of Michigan
发明人： Kang Kim , Jingping Xu , Jonathan M Rubin
摘要： A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.
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8.发明申请METHOD AND APPARATUS TO ENHANCE LIGHT ILLUMINATING INTENSITY AND DIFFUSIVITY 审中-公开方法和装置，以增强光照射强度和差异公开(公告)号：US20150005613A1
公开(公告)日：2015-01-01
申请号：US14366666
申请日：2012-12-21
发明人： Kang Kim , Zhaohui Wang , Seung Han Ha
CPC分类号： A61B5/0095 , A61B5/441 , A61B5/4836 , A61N5/0616 , A61N2005/063 , G01N21/1702 , G01N21/474 , G01N29/0654 , G01N29/2418
摘要： Photoacoustic probes include reflective surfaces situated to redirect scattered or reflected optical radiation from a specimen surface back to the specimen. A reflective coating can reflect probe radiation while transmitting visible radiation so that a technician can view the specimen. One or more optical fibers and acoustic transducers can be secured to a lens or other substrate on which the reflective surface is defined. The light collector is configured to block scattered light so that an operator and a subject are not exposed to the scattered light.
摘要翻译： 光声探测器包括反射表面，用于将来自样品表面的散射或反射的光辐射重新定向到样品。 反射涂层可以在透射可见辐射的同时反射探测辐射，从而技术人员可以观察样品。 可以将一个或多个光纤和声换能器固定到其上限定有反射表面的透镜或其它基板。 集光器被配置为阻挡散射光，使得操作者和被摄体不暴露于散射光。
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公开(公告)号：US20190282198A1
公开(公告)日：2019-09-19
申请号：US16430315
申请日：2019-06-03
发明人： Kang Kim , Ahmed M. Mahmoud , Debaditya Dutta
摘要： A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the target area using an ultrasound scanner, and quantifying the amount of fat in the targeted area based on the thermal strain imaging. In some embodiments, the thermal strain imaging is performed using high-resolution, phase-sensitive speckle tracking to differentiate between fat-based tissue and water-based tissue.
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公开(公告)号：US10357223B2
公开(公告)日：2019-07-23
申请号：US14409378
申请日：2013-07-03
发明人： Kang Kim , Ahmed M. Mahmoud , Debaditya Dutta
摘要： A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the target area using an ultrasound scanner, and quantifying the amount of fat in the targeted area based on the thermal strain imaging. In some embodiments, the thermal strain imaging is performed using high-resolution, phase-sensitive speckle tracking to differentiate between fat-based tissue and water-based tissue.
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