公开(公告)号：US20240001004A1

公开(公告)日：2024-01-04

申请号：US18037684

申请日：2021-11-18

Applicant: University of Virginia Patent Foundation

Inventor： Steven R. Caliari ,  Ivan Basurto

IPC: A61L27/56 ,  A61L27/38 ,  A61L27/26 ,  A61N1/05

CPC classification number: A61L27/56 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/26 ,  A61N1/05 ,  A61L2430/30

Abstract: A multicompartment conductive collagen scaffold composite, comprising a scaffold comprising collagen and an electrically conductive material, optionally wherein the electrically conductive material comprises electrically conductive particles, and further comprising longitudinally aligned pores, and methods of making and using the same.

公开(公告)号：US20240157023A1

公开(公告)日：2024-05-16

申请号：US18277752

申请日：2022-02-17

Applicant: University of Virginia Patent Foundation

Inventor： Steven R. Caliari ,  Erica Hui ,  Thomas H. Barker

IPC: A61L26/00 ,  A61K41/00

CPC classification number: A61L26/0061 ,  A61K41/00 ,  A61L26/0023 ,  A61L26/008 ,  A61L2300/252 ,  A61L2400/06

Abstract: Disclosed are phototunable hydrogels, compositions that include the same, and methods for using the same for treating wounds and/or injuries, for inhibiting formation of scar tissue at wound sites, for inhibiting fibrosis in subjects in need thereof, for inhibiting lung fibrosis and/or scarring in subject in need thereof, for inhibiting formation of myofibroblasts from fibroblasts, and for inhibiting expression of α-smooth muscle actin (α-SMA) and/or type I collagen in fibroblasts.

公开(公告)号：US20240181129A1

公开(公告)日：2024-06-06

申请号：US18277676

申请日：2022-02-17

Applicant: University of Virginia Patent Foundation

Inventor： Steven R. Caliari ,  Beverly Miller

IPC: A61L27/20 ,  A61L27/52 ,  A61L27/54

CPC classification number: A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/62 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/10 ,  A61L2430/30

Abstract: Injectable fibrous hydrogel are provided. The injectable fibrous hydrogels include a guest macromer of a hyaluronic acid (HA) backbone and host macromer of a HA backbone, the guest macromer is a HA electrospun hydrogel nanofiber functionalized with adamantane (Ad), and the host macromer is a HA electrospun hydrogel nanofiber functionalized with β-cyclodextrin (CD). Injectable formulations that include the fibrous hydrogels are also provided, as are methods of making and using the same.