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公开(公告)号：US07919520B2
公开(公告)日：2011-04-05
申请号：US12269429
申请日：2008-11-12
申请人： Upul Bandarage , Jon Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Shi Kai Tian , Tiansheng Wang
发明人： Upul Bandarage , Jon Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Shi Kai Tian , Tiansheng Wang
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D401/12 , C07C323/65 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D261/04 , C07D403/12 , C07D413/12
摘要： The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
摘要翻译： 本发明涉及抑制TACE的化合物，其组合物，以及使用这些化合物和组合物治疗疾病的方法。
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公开(公告)号：US20090176782A1
公开(公告)日：2009-07-09
申请号：US12269429
申请日：2008-11-12
申请人： Upul Bandarage , Jon Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Shi Kai Tian , Tiansheng Wang
发明人： Upul Bandarage , Jon Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Shi Kai Tian , Tiansheng Wang
IPC分类号： A61K31/40 , C07D207/48 , C07D413/12 , A61K31/5377 , A61P11/00 , A61P25/00 , A61P3/00 , A61P35/00
CPC分类号： C07D401/12 , C07C323/65 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D261/04 , C07D403/12 , C07D413/12
摘要： The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
摘要翻译： 本发明涉及抑制TACE的化合物，其组合物，以及使用这些化合物和组合物治疗疾病的方法。
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公开(公告)号：US07485664B2
公开(公告)日：2009-02-03
申请号：US10741164
申请日：2003-12-19
申请人： Upul Bandarage , Jon H. Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Tiansheng Wang , Shi-Kai Tian
发明人： Upul Bandarage , Jon H. Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Tiansheng Wang , Shi-Kai Tian
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D401/12 , C07C323/65 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D261/04 , C07D403/12 , C07D413/12
摘要： The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
摘要翻译： 本发明涉及抑制TACE的化合物，其组合物，以及使用这些化合物和组合物治疗疾病的方法。
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公开(公告)号：US20130023525A1
公开(公告)日：2013-01-24
申请号：US13454510
申请日：2012-04-24
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/4184 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D405/14 , A61P31/04 , A61K31/4545 , C07D491/056 , A61K31/4355 , C07D413/14 , A61K31/5377 , A61K31/5513 , C07D403/14 , C07D403/10
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号：US20120010222A1
公开(公告)日：2012-01-12
申请号：US13234634
申请日：2011-09-16
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/506 , A61K31/4184 , A61P31/04 , A61K31/4439
CPC分类号： C07D413/14 , A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译： 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗，预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
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公开(公告)号：US07569591B2
公开(公告)日：2009-08-04
申请号：US10901928
申请日：2004-07-29
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/4439 , C07D401/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号：US20130030004A1
公开(公告)日：2013-01-31
申请号：US11593418
申请日：2006-11-06
申请人： Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
发明人： Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
IPC分类号： A61K31/506 , C07D403/10 , A61K31/4184 , A61P31/04 , A61K31/4439 , C07D401/14 , A61K31/4545 , C07D403/14 , C07D401/10
CPC分类号： C07D403/04 , C07D401/04 , C07D403/14
摘要： The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, that inhibit bacterial gyrase and/or TopoIV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌促旋酶和/或TopoIV的式I化合物或其药学上可接受的盐以及包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US20090325955A1
公开(公告)日：2009-12-31
申请号：US12483312
申请日：2009-06-12
申请人： PAUL Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： PAUL Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/506 , A61K31/5377 , A61P31/04 , A61K31/519 , A61K31/4439 , A61K31/4184
CPC分类号： A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译： 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗，预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
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公开(公告)号：US07618974B2
公开(公告)日：2009-11-17
申请号：US10971573
申请日：2004-10-21
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean P. Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean P. Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌回旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US20060122196A9
公开(公告)日：2006-06-08
申请号：US10971573
申请日：2004-10-21
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/506 , C07D403/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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