公开(公告)号：US20190231883A1

公开(公告)日：2019-08-01

申请号：US16265663

申请日：2019-02-01

Applicant: Utah State University

Inventor： Randolph V. Lewis ,  Justin A. Jones ,  Thomas Harris ,  Deven Smuin

IPC: A61K47/42 ,  A61K9/00 ,  A61K9/06 ,  A61K47/12 ,  A61K47/26

CPC classification number: A61K47/42 ,  A61K9/0063 ,  A61K9/06 ,  A61K47/12 ,  A61K47/26

Abstract: The present disclosure relates to drug delivery compositions that include recombinant spider silk and a medicinal agent and methods for preparing such materials and delivery medicinal agents. The disclosure also relates to compositions and methods of treating periodontal disease. A drug delivery composition can include a spider silk protein and a medicinal agent. The drug delivery composition can be in the form of a fiber, a solution, a gel, a hydrogel, a solid chip, a film, an adhesive, or a coating.

公开(公告)号：US12065660B2

公开(公告)日：2024-08-20

申请号：US16995372

申请日：2020-08-17

Applicant: Utah State University

Inventor： Randolph V. Lewis ,  Justin A. Jones ,  Xiaoli Zhang

IPC: C12N15/85 ,  C07K14/46 ,  C07K14/78

CPC classification number: C12N15/8509 ,  C07K14/461 ,  C07K14/78 ,  A01K2217/07 ,  A01K2227/706

Abstract: Transgenic silkworms stably expressing hagfish thread keratin genes or composite silkworm/hagfish thread keratin genes are disclosed. The exogenous hagfish thread keratin genes are stably integrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic hagfish thread keratin proteins and composite hagfish thread keratin-silkworm genes and proteins are provided. The expression of exogenous hagfish thread keratin genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/hagfish thread keratin fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.

公开(公告)号：US20150047532A1

公开(公告)日：2015-02-19

申请号：US14459244

申请日：2014-08-13

Applicant: Utah State University

Inventor： Randolph V. Lewis ,  Justin A. Jones

IPC: C07K14/435 ,  B29D99/00 ,  B29C47/00 ,  C09D189/00 ,  C08L89/00

CPC classification number: B29D99/0078 ,  B29K2089/00 ,  B29L2031/731 ,  C07K14/43518 ,  C08H1/00 ,  C08L89/00 ,  C09D189/00 ,  D01F4/02

Abstract: A method for solubilizing recombinant spider silk proteins in an aqueous solutions, where the method includes mixing recombinant spider silk proteins with water to form a mixture and heating the mixture in a closed vessel to form a solution.

Abstract translation: 一种将重组蜘蛛丝蛋白溶解在水溶液中的方法，其中所述方法包括将重组蜘蛛丝蛋白与水混合以形成混合物并在密闭容器中加热混合物以形成溶液。