公开(公告)号：US08913248B2

公开(公告)日：2014-12-16

申请号：US13489368

申请日：2012-06-05

申请人： Utkarsh Sharma ,  Lingfeng Yu ,  Alexandre R. Tumlinson ,  Matthew J. Everett

发明人： Utkarsh Sharma ,  Lingfeng Yu ,  Alexandre R. Tumlinson ,  Matthew J. Everett

IPC分类号： G01B9/02 ,  G01B11/02 ,  A61B5/00 ,  A61B3/10

CPC分类号： A61B5/0066 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02058 ,  G01B9/0207 ,  G01B9/02091

摘要： Systems and methods for reducing noise in balanced detection based optical coherence tomography (OCT) systems are described. Embodiments including both optical hardware and electronic based solutions to spectrally filter and attenuate the source reference light in optical coherence tomography in an effort to reduce RIN and FPN noise in OCT systems are presented. A novel application to electronic balanced detection schemes in which a single source of reference detection is balanced against the interferometric signals from multiple interferometers is also presented.

摘要翻译： 描述了基于平衡检测的光学相干断层扫描（OCT）系统中降低噪声的系统和方法。 提出了包括光学硬件和基于电子的解决方案的实施例，以在光学相干断层摄影中频谱滤波和衰减源参考光，以努力降低OCT系统中的RIN和FPN噪声。 还提出了一种电子平衡检测方案的新颖应用，其中单个参考检测源与来自多个干涉仪的干涉信号平衡。

公开(公告)号：US08433393B2

公开(公告)日：2013-04-30

申请号：US13543373

申请日：2012-07-06

申请人： Utkarsh Sharma ,  Matthew J. Everett ,  Lingfeng Yu

发明人： Utkarsh Sharma ,  Matthew J. Everett ,  Lingfeng Yu

IPC分类号： A61B5/00

CPC分类号： A61B3/102 ,  A61B5/0066 ,  A61B5/0261

摘要： Techniques for collecting and processing complex OCT data to detect localized motion contrast information with enhanced accuracy and sensitivity are presented. In a preferred embodiment, vector differences between complex OCT signals taken at the same location on the sample are used to detect blood flow in the retina. Additional embodiments involving non-linear intensity weighting of the motion contrast information, normalization of the vector difference amplitudes, and calculating the absolute value of the standard deviation of Doppler signal are described. Image processing techniques to enhance the images resulting from these motion contrast techniques are also presented.

公开(公告)号：US20130010302A1

公开(公告)日：2013-01-10

申请号：US13489368

申请日：2012-06-05

申请人： Utkarsh SHARMA ,  Lingfeng Yu ,  Alexandre R. Tumlinson ,  Matthew J. Everett

发明人： Utkarsh SHARMA ,  Lingfeng Yu ,  Alexandre R. Tumlinson ,  Matthew J. Everett

IPC分类号： G01B9/02

CPC分类号： A61B5/0066 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02058 ,  G01B9/0207 ,  G01B9/02091

摘要： Systems and methods for reducing noise in balanced detection based optical coherence tomography (OCT) systems are described. Embodiments including both optical hardware and electronic based solutions to spectrally filter and attenuate the source reference light in optical coherence tomography in an effort to reduce RIN and FPN noise in OCT systems are presented. A novel application to electronic balanced detection schemes in which a single source of reference detection is balanced against the interferometric signals from multiple interferometers is also presented.

摘要翻译： 描述了基于平衡检测的光学相干断层扫描（OCT）系统中降低噪声的系统和方法。 提出了包括光学硬件和基于电子的解决方案的实施例，以在光学相干断层摄影中频谱滤波和衰减源参考光，以努力降低OCT系统中的RIN和FPN噪声。 还提出了一种电子平衡检测方案的新颖应用，其中单个参考检测源与来自多个干涉仪的干涉信号平衡。

公开(公告)号：US20050185192A1

公开(公告)日：2005-08-25

申请号：US11063499

申请日：2005-02-22

申请人： Myung Kim ,  Lingfeng Yu

发明人： Myung Kim ,  Lingfeng Yu

IPC分类号： A61B5/00 ,  G01B9/02

CPC分类号： A61B5/0073 ,  A61B5/0066 ,  G01B9/02007 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795

摘要： Two-dimensional and three-dimensional optical coherence tomography is obtained by differential imaging of full-frame interference images using a white light source. Full-color tomographic imaging is also possible by processing the three-color channels of the interference images. A technique is described to obtain two-dimensional OCT images with full natural color representation. In a particular embodiment, the interference image is acquired using a color camera and the three-color channels are processed separately, recomposing the final image. In an additional embodiment, the interference images are acquired using separate red, blue and green light sources and the three color channels are combined to recompose the final image.

摘要翻译： 通过使用白光源对全帧干涉图像进行差分成像，获得二维和三维光学相干断层扫描。 通过处理干涉图像的三色通道也可以进行全色断层成像。 描述了一种技术来获得具有完全自然色彩表示的二维OCT图像。 在特定实施例中，使用彩色照相机获取干涉图像，并分别处理三色通道，重新构成最终图像。 在另外的实施例中，使用单独的红色，蓝色和绿色光源获取干涉图像，并且将三个颜色通道组合以重构最终图像。

公开(公告)号：US07317540B1

公开(公告)日：2008-01-08

申请号：US11290848

申请日：2005-11-30

申请人： Myung K. Kim ,  Lingfeng Yu

发明人： Myung K. Kim ,  Lingfeng Yu

IPC分类号： G01B11/02

CPC分类号： G01B9/02087 ,  G01B9/02007 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/1787

摘要： Two-dimensional and three-dimensional optical coherence tomography is obtained by differential imaging of full-frame interference images using a white light source. Full-color tomographic imaging is also possible by processing the three-color channels of the interference images. A technique is described to obtain two-dimensional OCT images with full natural color representation. In a particular embodiment, the interference image is acquired using a color camera and the three-color channels are processed separately, recomposing the final image. In an additional embodiment, the interference images are acquired using separate red, blue and green light sources and the three color channels are combined to recompose the final image.

摘要翻译： 通过使用白光源对全帧干涉图像进行差分成像，获得二维和三维光学相干断层扫描。 通过处理干涉图像的三色通道也可以进行全色断层成像。 描述了一种技术来获得具有完全自然色彩表示的二维OCT图像。 在特定实施例中，使用彩色照相机获取干涉图像，并分别处理三色通道，重新构成最终图像。 在另外的实施例中，使用单独的红色，蓝色和绿色光源获取干涉图像，并且将三个颜色通道组合以重构最终图像。

公开(公告)号：US07095503B2

公开(公告)日：2006-08-22

申请号：US11063499

申请日：2005-02-22

申请人： Myung K. Kim ,  Lingfeng Yu

发明人： Myung K. Kim ,  Lingfeng Yu

IPC分类号： G01B9/02

CPC分类号： A61B5/0073 ,  A61B5/0066 ,  G01B9/02007 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795

摘要： Two-dimensional and three-dimensional optical coherence tomography is obtained by differential imaging of full-frame interference images using a white light source. Full-color tomographic imaging is also possible by processing the three-color channels of the interference images. A technique is described to obtain two-dimensional OCT images with full natural color representation. In a particular embodiment, the interference image is acquired using a color camera and the three-color channels are processed separately, recomposing the final image. In an additional embodiment, the interference images are acquired using separate red, blue and green light sources and the three color channels are combined to recompose the final image.

摘要翻译： 通过使用白光源对全帧干涉图像进行差分成像，获得二维和三维光学相干断层扫描。 通过处理干涉图像的三色通道也可以进行全色断层成像。 描述了一种技术来获得具有完全自然色彩表示的二维OCT图像。 在特定实施例中，使用彩色照相机获取干涉图像，并分别处理三色通道，重新构成最终图像。 在另外的实施例中，使用单独的红色，蓝色和绿色光源获取干涉图像，并且将三个颜色通道组合以重构最终图像。