公开(公告)号：US07769432B2

公开(公告)日：2010-08-03

申请号：US10866913

申请日：2004-06-14

申请人： V. Suzanne Klimberg ,  Sohelia Korourian ,  Steven Harms ,  Gal Shafirstein

发明人： V. Suzanne Klimberg ,  Sohelia Korourian ,  Steven Harms ,  Gal Shafirstein

IPC分类号： A61B6/00 ,  A61B8/00

CPC分类号： A61B10/0233 ,  A61B10/0041 ,  A61B10/0283 ,  A61B2017/008 ,  A61B2018/2005 ,  A61B2090/374

摘要： The present invention provides a treatment method to excise a cancerous lesion, such as in the breast, with subsequent ablation of the margin. The method provides for location and excision with ablation under open guidance or guided imaging and for diagnosis by cytology. The method may be a minimally, invasive same day method with diagnosis before or immediately after excision. Also provided is a method of treating close or positive margins of an excisional site of a cancerous lesion in a breast by ablating the margin while monitoring the fluorescence of a fluorophor at the site to determine when ablation of the close or positive margin has occurred.

摘要翻译： 本发明提供了一种治疗方法，用于消除诸如乳房中的癌性病变，随后消融边缘。 该方法提供了在开放引导或引导成像下进行消融的定位和切除，并通过细胞学诊断。 该方法可以是在切除之前或之后具有诊断的最小侵入性同一天方法。 还提供了一种通过在监测位点处的荧光体的荧光的同时消除边缘来处理乳房中的癌性病变的切除部位的接近或正边缘的方法，以确定何时发生接近或正边缘的消融。

公开(公告)号：US07361173B2

公开(公告)日：2008-04-22

申请号：US11028157

申请日：2005-01-03

申请人： Gal Shafirstein ,  Scott L. Ferguson ,  Milton Waner

发明人： Gal Shafirstein ,  Scott L. Ferguson ,  Milton Waner

IPC分类号： A61B18/18

CPC分类号： A61B18/082 ,  A61B2017/00084 ,  A61B2017/00867

摘要： An apparatus and method for thermally destroying tumors in which heat is generated by electrical resistance heating conducted to the target tissue. Computerized scanning is used to optimize the geometry of a thermal probe. The probe has a metal tip heated by a remote laser. The metal tip is mounted on the end of a wave guide fiber for transmitting the laser radiation to the metal tip. The tip is coated with a thin layer of biocompatible ceramic to avoid coagulated tissue sticking to the tip. The tip has one or more thin, thermally-conductive elements which deploy in stages to coagulate the tumor. The conductive elements may be thin wires or blades. On one embodiment, the conductive elements are composed of a shape memory material that is folded against the tip at lower temperatures and deploys at selected higher temperatures. In another embodiment, the conductive elements are blades that are deployed mechanically. The tip may be provided with a miniature thermocouple to provide temperature feedback information.

摘要翻译： 一种用于热破坏肿瘤的装置和方法，其中通过对靶组织进行电阻加热而产生热量。 电脑扫描用于优化热探头的几何形状。 探头具有由远程激光加热的金属尖端。 金属尖端安装在波导纤维的端部，用于将激光辐射传送到金属尖端。 尖端涂有薄层的生物相容性陶瓷，以避免凝结的组织粘附到尖端。 尖端具有一个或多个薄的导热元件，其分阶段地部分地凝结肿瘤。 导电元件可以是细线或刀片。 在一个实施例中，导电元件由形状记忆材料构成，该材料在较低温度下折叠在尖端上并在选定的较高温度下展开。 在另一个实施例中，导电元件是机械部署的刀片。 尖端可以设置有微型热电偶以提供温度反馈信息。

公开(公告)号：US20050238539A1

公开(公告)日：2005-10-27

申请号：US10816016

申请日：2004-04-01

申请人： Gal Shafirstein ,  Scott Ferguson ,  Louis Fink ,  Paula North ,  Milton Waner

发明人： Gal Shafirstein ,  Scott Ferguson ,  Louis Fink ,  Paula North ,  Milton Waner

IPC分类号： B01L3/00 ,  B23Q15/24 ,  C12M3/08 ,  G01N1/04 ,  G01N1/06

CPC分类号： G01N1/06 ,  C12M45/07 ,  G01N2001/045

摘要： An apparatus for sectioning fresh unfixed tissue into very thin layers with preserved tissue architecture, antigenicity, mRNA content, and amenable to 3-D computer reconstruction. An electro-discharge machine (EDM) to accurately slice tissues through electro-dissociation of the tissue without mechanical or thermal damage. The tissue sample is placed on a holder submerged in a cooling bath comprising a liquid such as saline or water to minimize thermal effects and to provide a sink for dissociated ions. A cutting tool is electrically biased with respect to the tissue sample. A computer controlled EDM machine with x-y-z translation stage slices the tissue as defined by a predetermined program. The liquid in the cooling bath may be cooled to minimize tissue heating during cutting. In a preferred embodiment, the cutting tool may use focused RF energy to produce consecutive thin sections of fresh tissue for immunohistochemical and nucleic acids analyses by electro-dissociation without mechanical or thermal damage, ultimately allowing high-resolution volumetric reconstruction of gene and protein expression patterns of large tissue specimens.

摘要翻译： 将新鲜未固定组织切片成非常薄的装置，其具有保存的组织结构，抗原性，mRNA含量，并适用于3-D计算机重建。 一种放电机（EDM），用于通过组织的电解解来精确地切片组织，而没有机械或热损伤。 将组织样品放置在浸没在包含液体如盐水或水的冷却浴中的保持器上以最小化热效应并提供用于离解离子的沉淀。 切割工具相对于组织样品被电偏置。 具有x-y-z平移台的计算机控制的电火花成型机根据预定的程序限定组织切片。 冷却浴中的液体可以被冷却以最小化切割期间的组织加热。 在优选实施例中，切割工具可以使用聚焦RF能量来产生新鲜组织的连续薄片，用于免疫组织化学和核酸分析，通过电解解而没有机械或热损伤，最终允许基因和蛋白质表达模式的高分辨率体积重建 的大组织标本。

公开(公告)号：US06780177B2

公开(公告)日：2004-08-24

申请号：US10228482

申请日：2002-08-27

申请人： Gal Shafirstein ,  Scott L. Ferguson ,  Milton Waner

发明人： Gal Shafirstein ,  Scott L. Ferguson ,  Milton Waner

IPC分类号： A61B1818

CPC分类号： A61B18/082 ,  A61B2017/00084 ,  A61B2017/00867

摘要： An apparatus and method for thermally destroying tumors in which heat is generated by electrical resistance heating conducted to the target tissue. Computerized scanning is used to optimize the geometry of a thermal probe. The probe has a themally conductive tip containing an electrical resistance heating element. The thermally conductive tip is mounted on the end of a fiber that contains the electrical power leads and other electrical leads connecting to monitoring devices associated with the tip. The tip is coated with a thin layer of biocompatible ceramic to avoid coagulated tissue sticking to the tip. The tip has one or more thin, thermally-conductive elements which deploy in stages to coagulate the tumor. The conductive elements may be thin wires or blades. On one embodiment, the conductive elements are composed of a shape memory material that is folded against the tip at lower temperatures and deploys at selected higher temperatures. In another embodiment, the conductive elements are blades that are deployed mechanically. The tip may be provided with a miniature thermocouple to provide temperature feedback information. The resistance heating element may be pyrolytic graphite.

摘要翻译： 一种用于热破坏肿瘤的装置和方法，其中通过对靶组织进行电阻加热而产生热量。 电脑扫描用于优化热探头的几何形状。 探头具有包含电阻加热元件的导电尖端。 导热尖端安装在包含电力引线和连接到与尖端相关联的监测装置的其它电引线的光纤的端部上。 尖端涂有薄层的生物相容性陶瓷，以避免凝结的组织粘附到尖端。 尖端具有一个或多个薄的导热元件，其分阶段地部分地凝结肿瘤。 导电元件可以是细线或刀片。 在一个实施例中，导电元件由形状记忆材料构成，该材料在较低温度下折叠在尖端上并在选定的较高温度下展开。 在另一个实施例中，导电元件是机械部署的刀片。 尖端可以设置有微型热电偶以提供温度反馈信息。 电阻加热元件可以是热解石墨。

公开(公告)号：US09687268B2

公开(公告)日：2017-06-27

申请号：US14183788

申请日：2014-02-19

申请人： Gal Shafirstein ,  Anjay K. Khandelwal ,  James C. Walker

发明人： Gal Shafirstein ,  Anjay K. Khandelwal ,  James C. Walker

IPC分类号： A61B17/50 ,  A61B17/322

CPC分类号： A61B17/322

摘要： A dermatome including a battery unit, a handle, and a head portion. The head portion includes guards capable of being adjusted to control the width and the depth of the cut without an interruption in the medical procedure.

公开(公告)号：US20100318077A1

公开(公告)日：2010-12-16

申请号：US12806561

申请日：2010-08-16

申请人： Gal Shafirstein

发明人： Gal Shafirstein

IPC分类号： A61B18/04

CPC分类号： A61B18/082 ,  A61B18/20 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/00101 ,  A61B2017/00867 ,  A61B2018/00011 ,  A61B2018/00577 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/2005

摘要： An apparatus and method for thermally destroying tumors. A tip has a plurality of deployable thermal conductive elements whose temperatures are individually controllable. This allows the shape of the thermal field to be controlled and for specific areas to be protected from excessive heat by cooling those specific areas while ablating other areas. In another embodiment, the deployable thermal conductive elements are individually deployable to various lengths to further aid in shaping the thermal field. The temperatures and the shape of the thermal field may be monitored and controlled by a data processing device, such as a microprocessor. Further selectivity in defining the area of tissue to be treated may be achieved by introducing into the tissue thermal additives that alter the thermal properties of the tissue.

摘要翻译： 一种用于热破坏肿瘤的装置和方法。 尖端具有多个可部署的导热元件，其温度可单独控制。 这允许控制热场的形状并且通过在烧蚀其他区域时冷却这些特定区域来保护特定区域免受过热。 在另一个实施例中，可展开的导热元件可单独地展开到各种长度以进一步有助于成形热场。 热场的温度和形状可以由诸如微处理器的数据处理装置来监测和控制。 限定待处理组织面积的进一步的选择性可以通过将组织的热添加剂引入组织热添加剂来实现。

公开(公告)号：US20100298911A1

公开(公告)日：2010-11-25

申请号：US12661014

申请日：2010-03-09

申请人： Gal Shafirstein

发明人： Gal Shafirstein

IPC分类号： A61N5/067

CPC分类号： A61B18/203 ,  A61B2018/00452 ,  A61B2018/00458

摘要： A method and apparatus for personalized interactive laser therapy (PILT) treatment of Port Wine Stains (PWS) in real time in which low radiant exposure from a laser hand piece slightly heats up the treatment site while an infrared sensor in the laser hand piece measures the temperature increase. A mathematical algorithm calculates the vessel size distribution at the treatment site. The appropriate radiant exposure (based on the vessel size distribution) is then delivered to the treatment site.

摘要翻译： 一种用于个性化交互式激光治疗（PILT）实时处理端口葡萄酒渍（PWS）的方法和装置，其中来自激光手段的低辐射暴露稍微加热治疗部位，而激光手段中的红外传感器测量 温度升高。 数学算法计算处理部位的血管尺寸分布。 然后将适当的辐射暴露（基于血管尺寸分布）输送到治疗部位。

公开(公告)号：US20140378956A1

公开(公告)日：2014-12-25

申请号：US14482382

申请日：2014-09-10

申请人： Gal Shafirstein

发明人： Gal Shafirstein

IPC分类号： A61B18/08 ,  A61B18/20

CPC分类号： A61B18/082 ,  A61B18/20 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/00101 ,  A61B2017/00867 ,  A61B2018/00011 ,  A61B2018/00577 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/2005

摘要： An apparatus and method for thermally destroying tumors. A tip has a plurality of deployable thermal conductive elements whose temperatures are individually controllable. This allows the shape of the thermal field to be controlled and for specific areas to be protected from excessive heat by cooling those specific areas while ablating other areas. In another embodiment, the deployable thermal conductive elements are individually deployable to various lengths to further aid in shaping the thermal field. The temperatures and the shape of the thermal field may be monitored and controlled by a data processing device, such as a microprocessor. Further selectivity in defining the area of tissue to be treated may be achieved by introducing into the tissue thermal additives that alter the thermal properties of the tissue.

摘要翻译： 一种用于热破坏肿瘤的装置和方法。 尖端具有多个可部署的导热元件，其温度可单独控制。 这允许控制热场的形状并且通过在烧蚀其他区域时冷却这些特定区域来保护特定区域免受过热。 在另一个实施例中，可展开的导热元件可单独地展开到各种长度以进一步有助于成形热场。 热场的温度和形状可以由诸如微处理器的数据处理装置来监测和控制。 限定待处理组织面积的进一步的选择性可以通过将组织的热添加剂引入组织热添加剂来实现。

公开(公告)号：US08858545B2

公开(公告)日：2014-10-14

申请号：US12806561

申请日：2010-08-16

申请人： Gal Shafirstein

发明人： Gal Shafirstein

IPC分类号： A61B18/14 ,  A61B18/08 ,  A61B18/24 ,  A61B17/00 ,  A61B18/00

CPC分类号： A61B18/082 ,  A61B18/20 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/00101 ,  A61B2017/00867 ,  A61B2018/00011 ,  A61B2018/00577 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/2005

摘要： An apparatus and method for thermally destroying tumors. A tip has a plurality of deployable thermal conductive elements whose temperatures are individually controllable. This allows the shape of the thermal field to be controlled and for specific areas to be protected from excessive heat by cooling those specific areas while ablating other areas. In another embodiment, the deployable thermal conductive elements are individually deployable to various lengths to further aid in shaping the thermal field. The temperatures and the shape of the thermal field may be monitored and controlled by a data processing device, such as a microprocessor. Further selectivity in defining the area of tissue to be treated may be achieved by introducing into the tissue thermal additives that alter the thermal properties of the tissue.

摘要翻译： 一种用于热破坏肿瘤的装置和方法。 尖端具有多个可部署的导热元件，其温度可单独控制。 这允许控制热场的形状并且通过在烧蚀其他区域时冷却这些特定区域来保护特定区域免受过热。 在另一个实施例中，可展开的导热元件可单独地展开到各种长度以进一步有助于成形热场。 热场的温度和形状可以由诸如微处理器的数据处理装置来监测和控制。 限定待处理组织面积的进一步的选择性可以通过将组织的热添加剂引入组织热添加剂来实现。

公开(公告)号：US20080205776A1

公开(公告)日：2008-08-28

申请号：US11711738

申请日：2007-02-27

申请人： Gal Shafirstein ,  Xiaowei Xu ,  Mutlu Mete

发明人： Gal Shafirstein ,  Xiaowei Xu ,  Mutlu Mete

IPC分类号： G06K9/36

CPC分类号： G06K9/0014 ,  Y10S128/922 ,  Y10S128/925

摘要： An automated method for analyzing whether all cancerous or abnormal tissue has been removed as a result of surgical resection is disclosed. A number of tissue section slides are prepared representing all or a relatively large percentage of the tissue sample, and high-resolution digital microscopic images are formed of the sections. A clustering algorithm forms an image showing the healthy tissue margins, such representation being stored in a file of significantly smaller size than the original photograph. These two-dimensional image files may be formed into a three-dimensional image of the entire resected tissue, thereby improving the accuracy and ease by which a pathologist may determine if further surgery or radiation therapy, for example, are indicated.

摘要翻译： 公开了一种用于分析是否已经通过手术切除术去除所有癌性或异常组织的自动化方法。 准备了许多代表所有或相对较大比例的组织样本的组织切片，并且由分段形成高分辨率数字显微镜图像。 聚类算法形成显示健康组织边缘的图像，这种表示被存储在比原始照片小得多的文件中。 这些二维图像文件可以形成为整个切除的组织的三维图像，从而提高了病理学家可以确定是否进一步手术或放射疗法的准确性和容易程度。