公开(公告)号：US20140165221A1

公开(公告)日：2014-06-12

申请号：US14182705

申请日：2014-02-18

申请人： VERENIUM CORPORATION

发明人： DAVID P. WEINER ,  PETER LUGINBUHL ,  ANALIA BUENO ,  JOSLIN M. CUENCA ,  ERIN MARASCO

IPC分类号： C12N9/10 ,  C12N9/04 ,  C12N15/113

CPC分类号： C12N9/1096 ,  A21D8/042 ,  A61K38/00 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0014 ,  C12N9/10 ,  C12N15/1137 ,  C12N15/63 ,  C12N15/86 ,  C12P7/10 ,  C12Q1/6876 ,  C12Y206/01021 ,  D06L4/40 ,  D06M16/003 ,  G01N33/573 ,  Y02E50/16 ,  Y02P20/52 ,  Y02T50/678

摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., d-amino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H2O+acceptor a 2-oxo acid+NH3+reduced acceptor.

摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有转移酶活性的酶，例如转氨酶活性，例如d-氨基酸转移酶活性和/或氧化还原酶活性，例如 ，脱氢酶活性，例如，d-氨基酸脱氢酶活性和/或催化化学基团的转移，催化转氨酶，催化反应：D-丙氨酸+ 2-氧戊二酸酯<=>丙酮酸盐+ D-谷氨酸盐和/ 或催化氧化还原反应，催化氢原子的去除和/或催化反应：D-氨基酸+ H 2 O +受体<=> 2-氧代酸+ NH 3 +还原受体。