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    Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
    4.
    发明授权
    Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them 有权
    转移酶和氧化还原酶，编码它们的核酸以及制备和使用它们的方法

    公开(公告)号：US08709772B2

    公开(公告)日：2014-04-29

    申请号：US12810057

    申请日：2008-12-31

    申请人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca ,  Erin Marasco

    发明人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca ,  Erin Marasco

    IPC分类号： C12N9/10 ,  C12Q1/00 ,  C12Q1/68 ,  C12P21/06 ,  C12P21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P7/00 ,  C12P13/04 ,  C07H21/04

    CPC分类号： C12N9/1096 ,  A21D8/042 ,  A61K38/00 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0014 ,  C12N9/10 ,  C12N15/1137 ,  C12N15/63 ,  C12N15/86 ,  C12P7/10 ,  C12Q1/6876 ,  C12Y206/01021 ,  D06L4/40 ,  D06M16/003 ,  G01N33/573 ,  Y02E50/16 ,  Y02P20/52 ,  Y02T50/678

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H2O+acceptor a 2-oxo acid+NH3+reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有转移酶活性的酶，例如转氨酶活性，例如d-氨基酸转移酶活性和/或氧化还原酶活性，例如 ，脱氢酶活性，例如脱氨酸脱氢酶活性和/或催化化学基团的转移，催化转氨酶，催化反应：D-丙氨酸+ 2-氧戊二酸酯<=>丙酮酸盐+ D-谷氨酸盐和/或催化 催化氢原子的去除和/或催化反应：D-氨基酸+ H 2 O +受体 2-氧代酸+ NH 3 +还原受体。 因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。