公开(公告)号：US11248039B2

公开(公告)日：2022-02-15

申请号：US16566542

申请日：2019-09-10

申请人： VIB VZW ,  UNIVERSITEIT GENT ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  TRUSTEES OF DARTMOUTH COLLEGE

发明人： Xavier Saelens ,  Bert Schepens ,  Iebe Rossey ,  Barney Graham ,  Jason McLellan ,  Morgan Gilman

IPC分类号： C07K16/10 ,  A61P31/14 ,  A61K39/12 ,  A61K39/00

摘要： The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.

公开(公告)号：US20210106673A1

公开(公告)日：2021-04-15

申请号：US17078704

申请日：2020-10-23

申请人： VIB VZW ,  Universiteit Gent

发明人： Xavier Saelens ,  Bert Schepens ,  Walter Fiers

IPC分类号： A61K39/155 ,  A61K39/12 ,  C12N7/02 ,  A61K39/385 ,  C07K16/10 ,  C07K7/06 ,  C07K14/005 ,  C07K14/78 ,  C12N7/00

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

公开(公告)号：US20190083605A1

公开(公告)日：2019-03-21

申请号：US16144007

申请日：2018-09-27

申请人： VIB VZW ,  Universiteit Gent

发明人： Xavier Saelens ,  Bert Schepens ,  Walter Fiers

IPC分类号： A61K39/155 ,  C12N7/00 ,  C07K16/10 ,  A61K39/385 ,  C07K14/78 ,  C07K14/005 ,  C07K7/06 ,  A61K39/12 ,  C12N7/02 ,  A61K39/00

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

公开(公告)号：US10117926B2

公开(公告)日：2018-11-06

申请号：US15197001

申请日：2016-06-29

申请人： VIB VZW ,  Universiteit Gent

发明人： Xavier Saelens ,  Bert Schepens ,  Walter Fiers

IPC分类号： A61K39/155 ,  A61K39/12 ,  C07K16/10 ,  C12N7/02 ,  C07K7/06 ,  C07K14/005 ,  C07K14/78 ,  A61K39/385 ,  C12N7/00 ,  A61K39/00

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

公开(公告)号：US20160346379A1

公开(公告)日：2016-12-01

申请号：US15197001

申请日：2016-06-29

申请人： VIB VZW ,  Universiteit Gent

发明人： Xavier Saelens ,  Bert Schepens ,  Walter Fiers

IPC分类号： A61K39/155 ,  C07K16/10 ,  A61K39/385 ,  C12N7/00

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6075 ,  A61K2039/6081 ,  A61K2039/645 ,  C07K7/06 ,  C07K14/005 ,  C07K14/78 ,  C07K16/1027 ,  C07K2317/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N7/02 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

摘要翻译： 描述了一种针对呼吸道合胞病毒（RSV）的疫苗。 更具体地，描述了包含RSV编码的小疏水（SH）蛋白的胞外域的重组亚单位疫苗。 SH的胞外域被称为SHe。 胞外结构域通常以低聚物或五聚体形式存在。 还描述了针对胞外结构域或针对胞外结构域特异性的抗体，以及它们用于保护受试者免受RSV感染和/或用于治疗受感染受试者的用途。