公开(公告)号：US20240109843A1

公开(公告)日：2024-04-04

申请号：US18501244

申请日：2023-11-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  KING ABDULAZIZ UNIVERSITY ,  THE CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP) ,  IllExcor Therapeutics, LLC

Inventor： Martin SAFO ,  Yan ZHANG ,  Piyusha Pradeep PAGARE ,  Guoyan XU ,  Mohini GHATGE ,  Jurgen VENITZ ,  Osheiza ABDULMALIK ,  Andrew FLEISCHMAN ,  David LIGHT ,  Moustafa EL-ARABY ,  Abdelsattar OMAR

IPC: C07D213/80 ,  A61K9/00 ,  A61P7/00 ,  C07D213/79 ,  C07D401/04 ,  C07D409/04

CPC classification number: C07D213/80 ,  A61K9/0053 ,  A61P7/00 ,  C07D213/79 ,  C07D401/04 ,  C07D409/04

Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).

公开(公告)号：US20220340531A1

公开(公告)日：2022-10-27

申请号：US17846101

申请日：2022-06-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  THE CHILDREN'S HOSPITAL OF PHILADELPHIA

Inventor： Martin K. SAFO ,  Yan ZHANG ,  Piyusha Pradeep PAGARE ,  Guoyan XU ,  Mohini GHATGE ,  Jurgen VENITZ ,  Osheiza ABDULMALIK

IPC: C07D213/80 ,  A61P7/00 ,  A61K9/00 ,  C07D213/79 ,  C07D401/04 ,  C07D409/04

Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are based on vanillin which is chemically modified to increase bioavailability and activity, e.g. so that the compounds bind to the F helix of hemoglobin (Hb) and prevent adhesion of red blood cells (RBCs).

公开(公告)号：US20210002225A1

公开(公告)日：2021-01-07

申请号：US16982745

申请日：2019-03-18

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  THE CHILDREN'S HOSPITAL OF PHILADELPHIA

Inventor： Martin K. SAFO ,  Yan ZHANG ,  Piyusha Pradeep PARAGE ,  Guoyan XU ,  Mohini GHATGE ,  Jurgen VENITZ ,  Osheiza ABDULMALIK

IPC: C07D213/80 ,  C07D213/79 ,  C07D401/04 ,  C07D409/04 ,  A61K9/00 ,  A61P7/00

Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are based on vanillin which is chemically modified to increase bioavailability and activity, e.g. so that the compounds bind to the F helix of hemoglobin (Hb) and prevent adhesion of red blood cells (RBCs).

公开(公告)号：US20160326097A1

公开(公告)日：2016-11-10

申请号：US15107962

申请日：2014-12-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. SAFO ,  Richmond DANSO-DANQUAH ,  Mohini GHATGE ,  Jurgen VENITZ ,  Martin MANGINO ,  Kevin R. WARD

IPC: C07C235/38 ,  A61K33/00 ,  A61K45/06 ,  A61K31/216 ,  C07C245/24 ,  A61K31/655

CPC classification number: C07C235/38 ,  A61K31/216 ,  A61K31/40 ,  A61K31/655 ,  A61K33/00 ,  A61K45/06 ,  C07C245/24 ,  Y02A50/411 ,  A61K2300/00

Abstract: Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.

Abstract translation: 含有一氧化氮（NO）部分的血红蛋白的变构血红蛋白（Hb）改性剂允许体内释放NO。 化合物保留变构血红蛋白改性剂的氧传递能力以结合Hb并增强Hb将氧递送至细胞和组织的能力，并且还从NO部分释放NO。 还提供了向细胞和组织输送氧和/或NO的方法。

公开(公告)号：US20160221978A1

公开(公告)日：2016-08-04

申请号：US14913180

申请日：2014-08-21

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin SAFO ,  Jurgen VENITZ ,  Richmond DANSO-DANQUAH ,  Tanvi DESPANDE ,  Yan ZHANG

IPC: C07D307/58 ,  C07D213/30

CPC classification number: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

Abstract translation: 本发明提供了新的芳族醛化合物，其在提高Hb对于氧气的亲和力，更好的预防镰刀效力以及改善其他SCD症状的药理学性质方面具有更大的效力。 本发明还提供了通过向本发明的化合物提供具有SCD的受试者来治疗SCD的方法。