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1.发明申请公开(公告)号：US20250019349A1
公开(公告)日：2025-01-16
申请号：US18767363
申请日：2024-07-09
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY , IllExcor Therapeutics, LLC , KING ABDULAZIZ UNIVERSITY , CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP)
Inventor： Martin SAFO , Yan ZHANG , Andrew FLEISCHMAN , David LIGHT , Moustafa EL-ARABY , Abdelsattar OMAR , Osheiza ABDULMALIK
IPC: C07D213/30 , A61P7/06 , C07D239/26
Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).
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2.发明申请ESTER NITRATES DERIVATIVES OF AROMATIC ALDEHYDES WITH MULTIPLE PHARMALOGIC PROPERTIES TO TREAT SICKLE CELL DISEASE 审中-公开具有多种药物特性的芳香醛类化合物的衍生物治疗镰状细胞病公开(公告)号：US20160221978A1
公开(公告)日：2016-08-04
申请号：US14913180
申请日：2014-08-21
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Martin SAFO , Jurgen VENITZ , Richmond DANSO-DANQUAH , Tanvi DESPANDE , Yan ZHANG
IPC: C07D307/58 , C07D213/30
CPC classification number: C07D307/58 , C07D213/30
Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.
Abstract translation: 本发明提供了新的芳族醛化合物，其在提高Hb对于氧气的亲和力，更好的预防镰刀效力以及改善其他SCD症状的药理学性质方面具有更大的效力。 本发明还提供了通过向本发明的化合物提供具有SCD的受试者来治疗SCD的方法。
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3.发明公开公开(公告)号：US20240109843A1
公开(公告)日：2024-04-04
申请号：US18501244
申请日：2023-11-03
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY , KING ABDULAZIZ UNIVERSITY , THE CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP) , IllExcor Therapeutics, LLC
Inventor： Martin SAFO , Yan ZHANG , Piyusha Pradeep PAGARE , Guoyan XU , Mohini GHATGE , Jurgen VENITZ , Osheiza ABDULMALIK , Andrew FLEISCHMAN , David LIGHT , Moustafa EL-ARABY , Abdelsattar OMAR
IPC: C07D213/80 , A61K9/00 , A61P7/00 , C07D213/79 , C07D401/04 , C07D409/04
CPC classification number: C07D213/80 , A61K9/0053 , A61P7/00 , C07D213/79 , C07D401/04 , C07D409/04
Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).
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4.发明公开公开(公告)号：US20240174612A1
公开(公告)日：2024-05-30
申请号：US18386724
申请日：2023-11-03
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY , IllExcor Therapeutics, LLC , KING ABDULAZIZ UNIVERSITY , CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP)
Inventor： Martin SAFO , Yan ZHANG , Andrew FLEISCHMAN , David LIGHT , Moustafa EL-ARABY , Abdelsattar OMAR , Osheiza ABDULMALIK
IPC: C07D213/30 , A61P7/06 , C07D239/26
CPC classification number: C07D213/30 , A61P7/06 , C07D239/26
Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).
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