公开(公告)号：US20240299520A1

公开(公告)日：2024-09-12

申请号：US18276140

申请日：2022-02-08

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Guizhi ZHU ,  Yu ZHANG

IPC: A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C12N15/66

CPC classification number: A61K39/00119 ,  A61K39/001164 ,  A61K45/06 ,  A61P35/00 ,  C12N15/66 ,  C12Y101/01042 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/572

Abstract: Synthetic mini circular RNA vaccine constructs are provided. The synthetic mini circular RNA constructs encode one or more antigens and are used, for example, as vaccines against cancer or infectious agents. In some aspects, the one or more antigens are translated as concatemer peptides by rolling cycle translation (RCT) of the mini circular RNA.

公开(公告)号：US20240148900A1

公开(公告)日：2024-05-09

申请号：US18281108

申请日：2022-04-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Guizhi ZHU ,  Yu ZHANG

IPC: A61K47/69 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K47/6937 ,  A61K47/549 ,  A61P35/00

Abstract: Provided herein are pH-responsive nanovaccines (NVs) that stimulate the immune system. The NVs comprise nano- or micro-particles to which CDN-modified i-motif DNA is attached. When endocytosed within a subject to whom they are delivered, the change in pH to an acidic environment cause the CDNs to be released from the NVs. The CDNs are STING (stimulator of interferon genes) agonists and after their release, they bind to and activate STING, a critical step in stimulating the immune system. The NVs are used e.g. for cancer immunotherapy, to treat viral infections and/or as vaccine adjuvants.

公开(公告)号：US20220274040A1

公开(公告)日：2022-09-01

申请号：US17774389

申请日：2020-11-06

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION

Inventor： Sheng-Chieh CHEN ,  Weining WANG ,  Xiang HE ,  Yu ZHANG

IPC: B01D46/00 ,  B01D39/16 ,  B01D53/02 ,  B01J20/22 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

Abstract: Provided herein are electret-MOF filter embedded with particles derived from metal-organic frameworks (MOF) and their methods of manufacturing. The methods of manufacturing the electret-MOF filter can include suspending MOF particles in a solvent to form a MOF particle mixture, contacting a charged polymeric fibrous web with the MOF particle mixture, and coating the charged polymeric fibrous web with the MOF particles by flowing the MOF particle mixture through an inverse side of the polymeric fibrous web. The disclosed coating method can deposit MOF particles uniformly, without formation of films at interstitial spaces between fibers. The electret-MOF filter can simultaneously remove fine particulate matters (PMs) and hazardous gaseous pollutants (including volatile organic compounds (VOCs)) with high particle holding and gas adsorption capacities, and with very low air resistance.