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公开(公告)号：US20170240599A1
公开(公告)日：2017-08-24
申请号：US15508928
申请日：2015-08-29
申请人： Vadlamani SURESH KUMAR , Dagadu PATIL NILESH , Shafee MOHAMMED ABDUL , Patil SANJAY DEVIDAS , Narayanan GOVINDARAJAN , AURO PEPTIDES LTD
发明人： Suresh Kumar Vadlamani , Patil Nilesh Dagadu , Shafee Mohammed Abdul , Sanjay Devidas Patil , Govindrajan Narayanan
CPC分类号： C07K7/08 , B01D15/325 , B01D15/426
摘要： The present invention relates to a process for the preparation of Linaclotide by oxidizing linear Linaclotide of formula (II) using combination of air and oxidizing agent followed by purification using RP-HPLC.
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公开(公告)号：US20180251511A1
公开(公告)日：2018-09-06
申请号：US15523384
申请日：2015-10-31
申请人： Vadlamami SURESH KUMAR , Dagadu PATIL NILESH , Shafee MOHAMMED ABDUL , Patil SANJAY DEVIDAS , Agasaladinni NAGANAGOUD , AURO PEPTIDES LTD
发明人： Suresh Kumar Vadlamani , Patil Nilesh Dagadu , Mohammed Abdul Shafee , Sanjay Devidas Patil , Nagana Goud Agasaladinni
IPC分类号： C07K14/605
CPC分类号： C07K14/605
摘要： The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.
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公开(公告)号：US11572386B2
公开(公告)日：2023-02-07
申请号：US15508928
申请日：2015-08-29
申请人： AURO PEPTIDES LTD , Suresh Kumar Vadlamani , Patil Nilesh Dagadu , Shafee Mohammed Abdul , Sanjay Devidas Patil , Govindrajan Narayanan
发明人： Suresh Kumar Vadlamani , Patil Nilesh Dagadu , Shafee Mohammed Abdul , Sanjay Devidas Patil , Govindrajan Narayanan
摘要： The present invention relates to a process for the preparation of Linaclotide by oxidizing linear Linaclotide of formula (II) using combination of air and oxidizing agent followed by purification using RP-HPLC.
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公开(公告)号：US10344069B2
公开(公告)日：2019-07-09
申请号：US15523384
申请日：2015-10-31
申请人： Auro Peptides Ltd , Suresh Kumar Vadlamani , Patil Nilesh Dagadu , Mohammed Abdul Shafee , Sanjay Devidas Patil , Nagana Goud Agasaladinni
发明人： Suresh Kumar Vadlamani , Patil Nilesh Dagadu , Mohammed Abdul Shafee , Sanjay Devidas Patil , Nagana Goud Agasaladinni
IPC分类号： C07K14/605
摘要： The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.
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