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公开(公告)号：US09211214B2
公开(公告)日：2015-12-15
申请号：US13426470
申请日：2012-03-21
CPC分类号： A61F9/00821 , A61B2018/2035 , A61F9/00823 , A61F2009/00844 , A61F2009/00863 , A61N5/062 , A61N2005/063 , A61N2005/0643 , A61N2005/0667 , A61N2005/067
摘要： A laser system including: a laser source operable to emit a first and a second laser beam having first and second operating wavelengths, respectively; a fiber optic cable to guide and homogenize the laser beams; an expander to increase the diameter of the laser beams; a cylinder to guide the laser beams and limit respective diameters of the first and second laser beams, wherein the cylinder is positioned after the expander on an optical path of the laser beam; a first optical system to collimate the laser beams, wherein the optical system is positioned after the cylinder on the optical path of the laser beams; a spot-size selector comprising a plurality of apertures, wherein the spot-size selector is positioned after the first optical system on the optical path of the laser beams; and a second optical system to focus the laser beams on a tissue of the patient.
摘要翻译： 一种激光系统，包括：激光源，其可操作地分别发射具有第一和第二工作波长的第一和第二激光束; 用于引导和均匀化激光束的光纤电缆; 一个扩张器来增加激光束的直径; 引导激光束并限制第一和第二激光束的相应直径的圆柱体，其中圆柱体位于激光束的光路上的扩展器之后; 用于准直激光束的第一光学系统，其中光学系统位于激光束的光路上的圆柱体之后; 一个点尺寸选择器，包括多个孔，其中光斑尺寸选择器位于激光束的光路上的第一光学系统之后; 以及将激光束聚焦在患者的组织上的第二光学系统。
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公开(公告)号：US20130253411A1
公开(公告)日：2013-09-26
申请号：US13426470
申请日：2012-03-21
CPC分类号： A61F9/00821 , A61B2018/2035 , A61F9/00823 , A61F2009/00844 , A61F2009/00863 , A61N5/062 , A61N2005/063 , A61N2005/0643 , A61N2005/0667 , A61N2005/067
摘要： A laser system including: a laser source operable to emit a first and a second laser beam having first and second operating wavelengths, respectively; a fiber optic cable to guide and homogenize the laser beams; an expander to increase the diameter of the laser beams; a cylinder to guide the laser beams and limit respective diameters of the first and second laser beams, wherein the cylinder is positioned after the expander on an optical path of the laser beam; a first optical system to collimate the laser beams, wherein the optical system is positioned after the cylinder on the optical path of the laser beams; a spot-size selector comprising a plurality of apertures, wherein the spot-size selector is positioned after the first optical system on the optical path of the laser beams; and a second optical system to focus the laser beams on a tissue of the patient.
摘要翻译： 一种激光系统，包括：激光源，其可操作地分别发射具有第一和第二工作波长的第一和第二激光束; 用于引导和均匀化激光束的光纤电缆; 一个扩张器来增加激光束的直径; 引导激光束并限制第一和第二激光束的相应直径的圆柱体，其中圆柱体位于激光束的光路上的扩展器之后; 用于准直激光束的第一光学系统，其中光学系统位于激光束的光路上的圆柱体之后; 一个点尺寸选择器，包括多个孔，其中点尺寸选择器位于激光束的光路上的第一光学系统之后; 以及将激光束聚焦在患者的组织上的第二光学系统。
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3.发明申请SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION 审中-公开持续释放活性药剂以治疗玻尿酸和高血压公开(公告)号：US20130053794A1
公开(公告)日：2013-02-28
申请号：US13598573
申请日：2012-08-29
CPC分类号： A61K31/5575 , A61F9/0017 , A61F9/00772 , A61F9/00781 , A61K9/0051 , A61K9/0092 , A61K31/216
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.
摘要翻译： 在有需要的患者的眼睛中减少眼内压（IOP）的方法包括将第一泪液植入物通过第一泪点植入，并进入患者眼睛的第一泪小管。 该方法还可以包括将第二泪液植入物植入穿过第二泪点并进入患者眼睛的第二泪小管，并持续释放治疗有效量的眼内压降治疗剂。
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公开(公告)号：US20100274204A1
公开(公告)日：2010-10-28
申请号：US12710855
申请日：2010-02-23
CPC分类号： A61F9/00772 , A61F2250/0003 , A61K9/0051
摘要： Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures.
摘要翻译： 公开了泪液植入物和相关方法，其提供眼泪内的泪点和相关小管内的牢固的可嵌入的保留。 泪液植入物可以包括植入体，其构造成用于至少部分插入通过泪点并进入小管。 植入体可以包括第一和第二部分，并且可以从限定纵向近端轴线的第一部分的近端延伸到限定纵向远侧轴线的第二部分的远端。 植入物本体可以被配置成使得当使用整体式扩张器植入时，在近轴和远轴之间存在成角度的交叉。 以这种方式，植入物主体的至少一部分可以抵靠位于或相对于小管曲率的远侧的泪小管的至少一部分偏置，从而使用解剖结构保留泪液植入物的植入位置。
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公开(公告)号：US10238535B2
公开(公告)日：2019-03-26
申请号：US12710855
申请日：2010-02-23
摘要： Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures.
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公开(公告)号：US20090105749A1
公开(公告)日：2009-04-23
申请号：US12231984
申请日：2008-09-05
申请人： Eugene de Juan , Cary J. Reich , Stephen Boyd , Alan R. Rapacki , Robert W. Shimizu , Valery Rubinchik , Charles Richard Kjellbotn
发明人： Eugene de Juan , Cary J. Reich , Stephen Boyd , Alan R. Rapacki , Robert W. Shimizu , Valery Rubinchik , Charles Richard Kjellbotn
CPC分类号： A61F9/00772 , A61B17/3468 , A61B2090/036
摘要： Insertion and extraction tool, systems, and methods for use with lacrimal implants. An insertion tool is disclosed that includes a proximal end, a distal end, and a tool body therebetween. The distal end includes a mechanical coupling to receive a cartridge preloaded with a lacrimal implant, and a plunger configured to dispense the lacrimal implant from a preloaded cartridge.
摘要翻译： 插入和提取工具，系统和使用泪道植入物的方法。 公开了一种插入工具，其包括近端，远端和其间的工具主体。 远端包括用于接收预先装有泪管植入物的药筒的机械联接器，以及配置成从预装药筒分配泪道植入物的柱塞。
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