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    DRUG CORES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS
    2.
    发明申请
    DRUG CORES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS 有权
    用于持续释放治疗药物的药物

    公开(公告)号：US20120187594A1

    公开(公告)日：2012-07-26

    申请号：US13367823

    申请日：2012-02-07

    申请人： Deepank Utkhede ,  Robert W. Shimizu ,  Rachna Jain ,  Stephen Boyd ,  Hanson S. Gifford ,  Eugene de Juan ,  Cary J. Reich

    发明人： Deepank Utkhede ,  Robert W. Shimizu ,  Rachna Jain ,  Stephen Boyd ,  Hanson S. Gifford ,  Eugene de Juan ,  Cary J. Reich

    IPC分类号： B28B11/12

    CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61F9/00772 ,  A61F2230/0069 ,  A61F2250/0067 ,  A61K31/5575 ,  A61K47/34 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/602 ,  A61L2300/802 ,  Y02A50/395

    摘要： A solid drug core insert can be manufactured by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into a sheath body. The injection can be conducted at subambient temperatures. The mixture is cured to form a solid drug-matrix core. The therapeutic agent can be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. A surface of the solid drug core is exposed, for example by cutting the tube, and the exposed surface of the solid drug core releases therapeutic quantities of the therapeutic agent when implanted into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, for example with a material substantially impermeable to the therapeutic agent, such that the therapeutic quantities are released through the exposed surface, thereby avoiding release of the therapeutic agent to non-target tissues.

    摘要翻译： 可以通过将包含治疗剂和基质前体的液体混合物注入鞘体来制造固体药物核心插入物。 注射可以在低于环境温度下进行。 将混合物固化以形成固体药物基质核心。 治疗剂可以是在约室温下的液体，其形成液滴在基质材料中的分散体。 固体药物核心的表面例如通过切割管而暴露，并且固体药物核心的暴露表面在植入患者体内释放治疗剂量。 在一些实施方案中，插入体抑制治疗剂的释放，例如具有对治疗剂基本上不可渗透的材料，使得治疗量通过暴露表面释放，从而避免将治疗剂释放到非靶组织 。

    Controlled release bioactive agent delivery device
    5.
    发明申请
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US20050287188A1

    公开(公告)日：2005-12-29

    申请号：US11203981

    申请日：2005-08-15

    申请人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    发明人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    IPC分类号： A61K9/00 ,  A61K31/58 ,  A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.

    摘要翻译： 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

    Method and apparatus for intraocular brachytherapy
    6.
    发明申请
    Method and apparatus for intraocular brachytherapy 失效
    眼内近距离放射疗法的方法和装置

    公开(公告)号：US20050277802A1

    公开(公告)日：2005-12-15

    申请号：US11056763

    申请日：2005-02-11

    申请人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

    发明人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

    IPC分类号： A61N5/00 ,  A61N5/10

    CPC分类号： A61N5/1017

    摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

    摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

    Liquid level sensing and monitoring system for medical fluid infusion systems
    7.
    发明授权
    Liquid level sensing and monitoring system for medical fluid infusion systems 失效
    液体液体输液系统液位感应监测系统

    公开(公告)号：US5563584A

    公开(公告)日：1996-10-08

    申请号：US152012

    申请日：1993-11-15

    申请人： R. Scott Rader ,  Eric H. Schallen ,  Alexander C. Walsh ,  Carl C. Awh ,  Eugene de Juan

    发明人： R. Scott Rader ,  Eric H. Schallen ,  Alexander C. Walsh ,  Carl C. Awh ,  Eugene de Juan

    IPC分类号： A61M5/168 ,  G08B21/00

    CPC分类号： A61M5/1684 ,  Y10S128/13 ,  Y10T137/7339

    摘要： A liquid level sensing and monitoring system for a medical fluid infusion system has an IV spike with a pressure sensor which contacts fluid in an infusion container such as an IV bag or bottle. When an adequate amount of fluid is in the container, the resulting pressure on the sensor is at a relatively high level; however, when the fluid reservoir is nearly depleted, the pressure on the sensor falls to a low level, thereby activating the sensor and associated control circuitry which operates an alarm or warning indicator. In lieu of the pressure sensor, the device may use a resistive or capacitive sensor. When the liquid level falls below the electrical sensor, its state changes, and the alarm circuitry is activated.

    摘要翻译： 用于医疗液体输注系统的液位感测和监测系统具有IV尖峰，其具有接触诸如IV袋或瓶的输注容器中的流体的压力传感器。 当容器中有足够量的流体时，传感器上产生的压力处于较高的水平; 然而，当流体储存器几乎耗尽时，传感器上的压力下降到低水平，由此激活操作警报或警告指示器的传感器和相关联的控制电路。 代替压力传感器，该装置可以使用电阻或电容传感器。 当液位低于电传感器时，其状态改变，并且报警电路被激活。

    Flexible Circuit Electrode Array with Wire or Film Support
    8.
    发明申请
    Flexible Circuit Electrode Array with Wire or Film Support 有权
    带电线或薄膜支架的柔性电路电极阵列

    公开(公告)号：US20080288036A1

    公开(公告)日：2008-11-20

    申请号：US12032627

    申请日：2008-02-15

    申请人： Robert J. Greenberg ,  Eugene de Juan ,  Mark S. Humayun ,  Kelly H. McClure ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Brian V. Mech ,  James Singleton Little ,  Mohamed Khaldi

    发明人： Robert J. Greenberg ,  Eugene de Juan ,  Mark S. Humayun ,  Kelly H. McClure ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Brian V. Mech ,  James Singleton Little ,  Mohamed Khaldi

    IPC分类号： A61N1/04

    CPC分类号： A61N1/0543 ,  A61N1/05 ,  A61N1/0541 ,  H05K1/0393 ,  H05K1/118

    摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.

    摘要翻译： 本发明涉及柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及嵌入在所述阵列中的至少一个支撑。 本发明还涉及一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及将电极阵列与互连衬垫连接的折叠柔性电路电缆。 本公开还涉及一种制造柔性电路电极阵列的方法，包括：沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 将所述柔性电路电极阵列加热到模具中以在所述柔性电路电极阵列中形成三维形状，至少在基层，顶层或基底与顶层之间嵌入支撑件，和/或折叠柔性电路电缆 至少一次将电极阵列与互连衬垫连接在一起。

    Controlled release bioactive agent delivery device
    9.
    发明申请
    Controlled release bioactive agent delivery device 审中-公开
    控制释放生物活性剂输送装置

    公开(公告)号：US20050281863A1

    公开(公告)日：2005-12-22

    申请号：US11203931

    申请日：2005-08-15

    申请人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    发明人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

    IPC分类号： A61K9/00 ,  A61K31/58 ,  A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides controlled release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer and the second polymer are hydrophobic. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making controlled release bioactive agent delivery devices.

    摘要翻译： 本发明提供控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物和所述第二聚合物是疏水性的。 本发明还提供了以受控释放方式将生物活性剂递送至患者的方法，以及制备控制释放的生物活性剂递送装置的方法。