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    Process of preparing N-substituted aldonamides
    1.
    发明授权
    Process of preparing N-substituted aldonamides 失效
    制备N-取代的异黄酮类药物的方法

    公开(公告)号：US5386018A

    公开(公告)日：1995-01-31

    申请号：US147699

    申请日：1993-11-04

    申请人： Van Au ,  Bijan Harichian ,  Michael I. Hill ,  Mikhail Raykh ,  Jerry J. Krupa

    发明人： Van Au ,  Bijan Harichian ,  Michael I. Hill ,  Mikhail Raykh ,  Jerry J. Krupa

    IPC分类号： C07C235/06 ,  C07H15/04 ,  C07G3/00

    CPC分类号： C07H15/04 ,  C07C235/06

    摘要： N-substituted aldonamides are synthesized by the reaction of alkylamines and aldonolactone. Commercially available sources of aldonolactones (e.g., lactobiono-1,5-lactone) include aldonic acid (e.g., lactobionic acid). The presence of the acid leads to the formation of an ammonium salt impurity. The ammonium salt formation during the synthesis of N-alkyl aldonamides was minimized by the addition of an external acid. External acids and, optionally, emulsifiers were utilized to substantially reduce or eliminate the formation of an ammonium salt and to obtain N-substituted aldonamides of high purity.

    摘要翻译： N-取代的异丁酰胺通过烷基胺和醛酮内酯的反应合成。 醛糖内酯（例如，乳糖-1,5-内酯）的商业来源包括醛糖酸（例如乳糖酸）。 酸的存在导致形成铵盐杂质。 通过加入外部酸，使N-烷基异黄酮合成期间的铵盐形成最小化。 使用外部酸和任选的乳化剂来显着降低或消除铵盐的形成并获得高纯度的N-取代的异黄酮酰胺。

    SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS
    7.
    发明申请
    SUNSCREEN COMPOSITION WITH POLYHYDROXY QUATERNARY AMMONIUM SALTS 有权
    含多羟基季铵盐的SUNSCREEN组合物

    公开(公告)号：US20130129644A1

    公开(公告)日：2013-05-23

    申请号：US13477564

    申请日：2012-05-22

    申请人： Bijan Harichian ,  Van Au ,  Neil Patrick Randle ,  Stephen Roy Barrow

    发明人： Bijan Harichian ,  Van Au ,  Neil Patrick Randle ,  Stephen Roy Barrow

    IPC分类号： A61K8/40 ,  A61Q17/04 ,  A61K8/35

    CPC分类号： A61K8/416 ,  A61Q17/04

    摘要： A cosmetic composition is provided including a water-insoluble UV-A organic sunscreen agent having a max ranging from 330 to 380 nm, a UV-B organic sunscreen agent having a max ranging from 280 to 400 nm, and a photoprotective enhancing agent which is a polyhydroxy quaternary ammonium salt such as bis(dihydroxypropyl)dimethylammonium chloride, in a cosmetically acceptable carrier, and wherein the composition exhibits an SPF value which is 1 to 30 units higher than in the absence of the photoprotective enhancing agent.

    摘要翻译： 提供一种化妆品组合物，其包含最大范围为330-380nm的水不溶性UV-A有机防晒剂，最大范围为280-400nm的UV-B有机防晒剂，以及光保护增强剂 多羟基季铵盐，例如双（二羟丙基）二甲基氯化铵，在化妆品上可接受的载体中，并且其中所述组合物表现出比不存在光保护性增强剂时高出1至30单位的SPF值。