公开(公告)号：US20240197671A1

公开(公告)日：2024-06-20

申请号：US18416734

申请日：2024-01-18

申请人： Vanda Pharmaceuticals Inc.

发明人： Marlene Michelle Dressman ,  John Joseph Feeney ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC分类号： A61K31/343 ,  A61K9/00 ,  A61K31/00 ,  A61K31/05 ,  A61K31/15 ,  A61K31/277 ,  A61K31/496 ,  A61K45/06 ,  G01N30/72 ,  G01N33/68 ,  G01N33/74 ,  G16H50/20

CPC分类号： A61K31/343 ,  A61K9/0053 ,  A61K9/006 ,  A61K31/00 ,  A61K31/05 ,  A61K31/15 ,  A61K31/277 ,  A61K31/496 ,  A61K45/06 ,  G01N30/7233 ,  G01N33/6893 ,  G01N33/74 ,  G16H50/20 ,  G01N2800/2864

摘要： Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20230210810A1

公开(公告)日：2023-07-06

申请号：US18183655

申请日：2023-03-14

申请人： Vanda Pharmaceuticals Inc.

发明人： Marlene Michelle Dressman ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC分类号： A61K31/343 ,  A61P25/20

CPC分类号： A61K31/343 ,  A61P25/20

摘要： Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20220168264A1

公开(公告)日：2022-06-02

申请号：US17651232

申请日：2022-02-15

申请人： Vanda Pharmaceuticals Inc.

发明人： Marlene Michelle Dressman ,  John Joseph Feeney ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC分类号： A61K31/343 ,  A61K31/00 ,  A61K45/06 ,  A61K31/15 ,  A61K31/277 ,  A61K31/496 ,  G01N30/72 ,  G16H50/20 ,  G01N33/74 ,  G01N33/68 ,  A61K9/00

摘要： Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20210205261A1

公开(公告)日：2021-07-08

申请号：US17206811

申请日：2021-03-19

申请人： Vanda Pharmaceuticals Inc.

发明人： Marlene Michelle Dressman ,  John Joseph Feeney ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC分类号： A61K31/343 ,  A61K31/00 ,  A61K45/06 ,  A61K31/15 ,  A61K31/277 ,  A61K31/496 ,  G01N30/72 ,  G16H50/20 ,  G01N33/74 ,  G01N33/68 ,  A61K9/00

摘要： Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20210161854A1

公开(公告)日：2021-06-03

申请号：US17169928

申请日：2021-02-08

申请人： Vanda Pharmaceuticals Inc.

发明人： Marlene Michelle Dressman ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC分类号： A61K31/343 ,  A61K31/00 ,  A61K45/06 ,  A61K31/15 ,  A61K31/277 ,  A61K31/496 ,  G01N30/72 ,  G16H50/20 ,  G01N33/74 ,  G01N33/68 ,  A61K9/00

摘要： Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20200179326A1

公开(公告)日：2020-06-11

申请号：US16792275

申请日：2020-02-16

申请人： Vanda Pharmaceuticals Inc.

发明人： Marlene Michelle Dressman ,  John Joseph Feeney ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC分类号： A61K31/343 ,  A61K9/00 ,  G01N33/68 ,  A61K31/496 ,  A61K31/277 ,  A61K31/15 ,  A61K45/06 ,  A61K31/00 ,  G01N33/74 ,  G16H50/20 ,  G01N30/72

摘要： Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20180071245A1

公开(公告)日：2018-03-15

申请号：US15822162

申请日：2017-11-26

申请人： Vanda Pharmaceuticals Inc.

发明人： Marlene Michelle Dressman ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC分类号： A61K31/343 ,  A61K9/00 ,  G01N33/68 ,  A61K31/00

CPC分类号： A61K31/343 ,  A61K9/0053 ,  A61K9/006 ,  A61K31/00 ,  A61K31/15 ,  A61K31/277 ,  A61K31/496 ,  A61K45/06 ,  G01N33/6893 ,  G01N2800/2864 ,  G16H50/20 ,  A61K2300/00

摘要： Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20170174617A1

公开(公告)日：2017-06-22

申请号：US15447946

申请日：2017-03-02

申请人： Vanda Pharmaceuticals, Inc.

发明人： Marlene Michelle Dressman ,  Deepak Phadke

IPC分类号： C07C231/12

CPC分类号： C07C231/12 ,  A61K31/133 ,  C07B2200/13 ,  C07C233/18 ,  C07C233/25 ,  C07C233/47 ,  C07C2601/02

摘要： Isolated metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]-methyl]propanamide, methods for their use, and compositions containing the metabolites.

公开(公告)号：US09617203B2

公开(公告)日：2017-04-11

申请号：US14937786

申请日：2015-11-10

申请人： Vanda Pharmaceuticals, Inc.

发明人： Marlene Michelle Dressman ,  Deepak Phadke

IPC分类号： A61K31/133 ,  C07C233/47 ,  C07C233/25 ,  C07C233/18

CPC分类号： C07C231/12 ,  A61K31/133 ,  C07B2200/13 ,  C07C233/18 ,  C07C233/25 ,  C07C233/47 ,  C07C2601/02

摘要： Isolated metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]-methyl]propanamide, methods for their use, and compositions containing the metabolites.

公开(公告)号：US20160060212A1

公开(公告)日：2016-03-03

申请号：US14937786

申请日：2015-11-10

申请人： Vanda Pharmaceuticals, Inc.

发明人： Marlene Michelle Dressman ,  Deepak Phadke

IPC分类号： C07C233/47 ,  C07C233/18

CPC分类号： C07C231/12 ,  A61K31/133 ,  C07B2200/13 ,  C07C233/18 ,  C07C233/25 ,  C07C233/47 ,  C07C2601/02

摘要： Isolated metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]-methyl]propanamide, methods for their use, and compositions containing the metabolites.