公开(公告)号：US20220289673A1

公开(公告)日：2022-09-15

申请号：US17631114

申请日：2020-07-29

Applicant: Vanderbilt University

Inventor： William P. Tansey ,  Stephen W. Fesik ,  Shaun R. Stauffer ,  Alex G. Waterson ,  Changho Han ,  Joseph R. Alvarado ,  Jonathan D. MacDonald ,  Selena Chacon Simon ,  Sameer S. Nikhar ,  Alexey Kuznetsov

IPC: C07C311/21 ,  C07C311/29 ,  C07C311/39 ,  C07C311/43 ,  C07C317/34 ,  C07C317/38 ,  C07C317/48 ,  C07C323/49 ,  C07C381/00 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/48 ,  C07D207/27 ,  C07D213/40 ,  C07D213/56 ,  C07D213/64 ,  C07D215/36 ,  C07D233/36 ,  C07D239/26 ,  C07D249/14 ,  C07D265/30 ,  C07D241/04 ,  C07D305/08 ,  C07D307/14 ,  C07D307/18 ,  C07D307/22 ,  C07D307/52 ,  C07D307/79 ,  C07D309/04 ,  C07D309/10 ,  C07D309/14 ,  C07D309/22 ,  C07D333/20 ,  C07D333/24

Abstract: Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

公开(公告)号：US20230022304A1

公开(公告)日：2023-01-26

申请号：US17777686

申请日：2020-11-18

Applicant: Vanderbilt University

Inventor： Selena Chacon Simon ,  Alex Waterson ,  Jonathan D. MacDonald ,  Stephen Fesik ,  Shaun R. Stauffer ,  William P. Tansey

IPC: C07D233/88 ,  C07D405/06 ,  C07D401/12 ,  C07D403/04 ,  C07D231/42 ,  C07D249/14 ,  C07D277/82 ,  C07D277/54 ,  C07D403/06 ,  C07D403/12

Abstract: Substituted N-heteroaryl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject such as cancer cell proliferation.