公开(公告)号：US20220409772A1

公开(公告)日：2022-12-29

申请号：US17715829

申请日：2022-04-07

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Sichang Lu ,  Madison A.P. McGough ,  Katarzyna J. Zienkiewicz

IPC分类号： A61L27/48 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L27/46 ,  C08G18/77 ,  C08G18/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  C04B26/16 ,  C08G18/10 ,  C08G18/38 ,  C08G18/80

摘要： A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.

公开(公告)号：US20180311413A1

公开(公告)日：2018-11-01

申请号：US15768810

申请日：2016-10-17

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Sichang Lu ,  Madison A.P. McGough ,  Katarzyna L. Zienkiewicz

IPC分类号： A61L27/48 ,  C08G18/38 ,  C08G18/80 ,  C08G18/10 ,  C04B26/16 ,  A61L27/20 ,  A61L27/18 ,  A61L27/26 ,  A61L27/58 ,  A61L27/56 ,  A61L27/10 ,  A61L27/54

CPC分类号： A61L27/46 ,  A01K2207/20 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/404 ,  A61L2400/06 ,  C08L75/04

摘要： A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.

公开(公告)号：US20240335592A1

公开(公告)日：2024-10-10

申请号：US18743016

申请日：2024-06-13

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Sichang Lu ,  Madison A.P. McGough ,  Katarzyna J. Zienkiewicz

IPC分类号： A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C04B111/00 ,  C08G18/10 ,  C08G18/38 ,  C08G18/48 ,  C08G18/77 ,  C08G18/80

CPC分类号： A61L27/48 ,  A61L27/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C04B26/16 ,  C08G18/10 ,  C08G18/3868 ,  C08G18/4833 ,  C08G18/771 ,  C08G18/8061 ,  A01K2207/20 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  C04B2111/00836

摘要： A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.