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公开(公告)号:US20180194717A1
公开(公告)日:2018-07-12
申请号:US15850006
申请日:2017-12-21
发明人: Rao S. Bezwada
IPC分类号: C07C235/12 , A61L31/10 , C07C229/42 , C07C265/14 , C07C237/36 , C07C265/12 , A61K47/34 , C07C235/10
CPC分类号: C07C235/12 , A61K47/34 , A61L15/26 , A61L17/10 , A61L24/046 , A61L26/0019 , A61L27/18 , A61L31/06 , A61L31/10 , A61L2420/00 , C07C229/36 , C07C229/42 , C07C235/10 , C07C237/36 , C07C265/12 , C07C265/14 , C08G18/38 , C08G18/48 , C08G18/4837 , C08G18/6607 , C08G18/771 , C08G18/7812 , C08G2101/00 , Y10T428/139 , Y10T428/249921 , Y10T442/10 , C08L77/04
摘要: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.
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公开(公告)号:US09950996B2
公开(公告)日:2018-04-24
申请号:US15539189
申请日:2015-12-23
IPC分类号: C07C263/12 , C07C247/24 , C08G18/77 , C08G18/32 , C08G18/24 , C08G71/04 , C07C265/14
CPC分类号: C07C263/12 , C07C247/24 , C07C265/14 , C08G18/246 , C08G18/3206 , C08G18/771 , C08G71/04
摘要: The present invention provides bio-based aromatic diisocyanate of formula (I). [Formula should be inserted here] wherein X is OCH3, Y is selected from —H or OCH3, and m=0-12. The present invention further provides a method for preparation of aromatic diisocyanate of formula (I) useful for preparation of polyurethane.
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公开(公告)号:US20170313808A1
公开(公告)日:2017-11-02
申请号:US15652135
申请日:2017-07-17
IPC分类号: C08G18/73 , C08G18/42 , A61L27/18 , C08G64/02 , C08G18/48 , A61L27/52 , A61L24/00 , C08G18/34 , C08G18/32 , C08G18/12 , C08L75/04 , C08G18/44
CPC分类号: C08G18/73 , A61L24/0021 , A61L27/18 , A61L27/52 , A61L27/54 , A61L2300/404 , A61L2300/416 , A61L2300/426 , A61L2400/06 , A61L2430/06 , C08G18/12 , C08G18/244 , C08G18/3206 , C08G18/341 , C08G18/4244 , C08G18/428 , C08G18/4283 , C08G18/44 , C08G18/4808 , C08G18/4837 , C08G18/4854 , C08G18/4887 , C08G18/758 , C08G18/771 , C08G64/0241 , C08G2230/00 , C08L75/04 , C09J133/18 , C08G18/3228 , C08L75/06 , C08L71/02
摘要: Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.
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公开(公告)号:US20170226243A1
公开(公告)日:2017-08-10
申请号:US15581229
申请日:2017-04-28
IPC分类号: C08F122/20 , C09J135/02
CPC分类号: C08F122/20 , C07D493/04 , C08G18/3218 , C08G18/771 , C08L75/08 , C08L2201/50 , C09J4/00 , C09J135/02
摘要: The present invention relates to tackifier compounds and methods of using the same. In various embodiments, the present invention provides a tackifier compound including independently substituted or unsubstituted fused rings A and B each independently chosen from (C5-C10)cycloalkyl and (C2-C10)heterocyclyl. Fused ring A is substituted with (R1)1-8 and fused ring B is substituted with —(OC(O)R′C(O)R2)1-8. At each occurrence R′ is independently chosen from (C2-C10)alkanylene, (C2-C10)alkenylene, (C2-C10)alkynylene, (C5-C20(arylene), and (C1-C20)heteroarylene, wherein R′ is unsubstituted or substituted. At each occurrence R′ is independently selected from —OH, —OR3, and —OC(O)R′C(O)R2. At each occurrence R2 is independently chosen from —OH, —OR3, —NH2, —NHR3, and —NR32. At each occurrence R3 is independently chosen from (C1-C10)alkanyl, (C2-C10)alkenyl, (C2-C10)alkynyl, C5-C20(aryl), and (C1-C20)heteroaryl, wherein R3 is unsubstituted or substituted.
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公开(公告)号:US09573889B2
公开(公告)日:2017-02-21
申请号:US15048541
申请日:2016-02-19
IPC分类号: C07C265/14 , C07C263/10 , C07C263/20 , C01B31/28 , C08G18/00 , C08G18/77 , C08G18/32
CPC分类号: C07C265/14 , C01B32/80 , C07C263/10 , C07C263/20 , C08G18/3206 , C08G18/771
摘要: A method of making an amino acid triisocyanate is provided, the method comprising reacting an amino acid trihydrochloride with phosgene to form the amino acid triisocyanate. In some embodiments, the amino acid trihydrochloride comprises lysine ester trihydrochloride salt and the amino acid triisocyanate comprises lysine ester triisocyanate. In some embodiments, there is a lysine ester triisocyanate having a purity of at least about 98%, the lysine ester triisocyanate having a structure resulting from reacting lysine ester trihydrochloride salt with phosgene to form the lysine ester triisocyanate. These lysine ester triisocyanates can be used to make biodegradable polyurethanes.
摘要翻译: 提供了制备氨基酸三异氰酸酯的方法,该方法包括使氨基酸三盐酸盐与光气反应形成氨基酸三异氰酸酯。 在一些实施方案中,氨基酸三盐酸盐包含赖氨酸三盐酸盐,氨基酸三异氰酸酯包含赖氨酸三异氰酸酯。 在一些实施方案中,存在纯度为至少约98%的赖氨酸三异氰酸酯,赖氨酸三异氰酸酯具有由赖氨酸三盐酸盐与光气反应形成赖氨酸三异氰酸酯的结构。 这些赖氨酸酯三异氰酸酯可用于制造可生物降解的聚氨酯。
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公开(公告)号:US20160289412A1
公开(公告)日:2016-10-06
申请号:US15038705
申请日:2014-12-02
IPC分类号: C08J11/16 , C07C263/10 , C07C265/04 , C07D317/28 , C08G18/48 , C08J11/28 , C08G18/58 , C08J11/24 , C08L75/08 , C08J5/24 , C08K7/06 , C08K3/04 , C07C265/12 , C08G18/77
CPC分类号: C08J11/16 , B32B5/26 , B32B2260/023 , B32B2260/046 , B32B2262/101 , B32B2262/106 , B32B2307/716 , B32B2307/7163 , C07C263/00 , C07C263/10 , C07C265/00 , C07C265/04 , C07C265/08 , C07C265/10 , C07C265/12 , C07C265/14 , C07D317/28 , C08G18/4841 , C08G18/58 , C08G18/771 , C08G2230/00 , C08J5/24 , C08J11/24 , C08J11/28 , C08J2375/08 , C08K3/04 , C08K3/041 , C08K7/06 , C08L75/08 , C08L2201/06 , C08L2203/16 , C08L2205/025 , C08L2207/20
摘要: Degradable isocyanate compounds, methods for making these compounds, and uses of these compounds for preparing degradable cross-linked polymers and composite materials are provided.
摘要翻译: 提供可降解异氰酸酯化合物,制备这些化合物的方法,以及这些化合物用于制备可降解交联聚合物和复合材料的用途。
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公开(公告)号:US09458332B2
公开(公告)日:2016-10-04
申请号:US14650791
申请日:2013-09-10
申请人: BYK-Chemie GmbH
发明人: Daniela Leutfeld , René Nagelsdiek , Jürgen Omeis , Jasmin Rudner
CPC分类号: C09D7/65 , C08G18/28 , C08G18/2825 , C08G18/283 , C08G18/284 , C08G18/3819 , C08G18/3825 , C08G18/7621 , C08G18/771 , C08G18/792 , C08G18/8064 , C08K5/20 , C08L75/02 , C08L75/04 , C09D5/04 , C09D17/002 , C10M161/00 , C10M2201/08 , C10M2215/08 , C10M2215/0806 , C10M2215/102 , C10M2217/0456 , C09D175/04 , C08L75/12 , C09D175/06
摘要: The present invention relates to a composition effective as a rheology additive containing 15-95 wt.-% of an oxygen compound (A), 5-75 wt.-% of a urea compound (B), 0-50 wt.-% of an ionogenic compound (C) and 0-35 wt.-% of an organic solvent (D).
摘要翻译: 本发明涉及作为流变助剂有效的组合物,其含有15-95重量%的氧化合物(A),5-75重量%的脲化合物(B),0-50重量% 的离子型化合物(C)和0-35重量%的有机溶剂(D)。
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公开(公告)号:US09422393B2
公开(公告)日:2016-08-23
申请号:US14079171
申请日:2013-11-13
申请人: Patrick T. Mather , Gu Xinzhu
发明人: Patrick T. Mather , Gu Xinzhu
CPC分类号: C08G18/4833 , C08G18/4018 , C08G18/4277 , C08G18/771 , C08G2280/00
摘要: Water-triggered shape memory polymers based on poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) multiblock hybrid thermoplastic polyurethanes. Urethane linkages were formed through the addition reaction between isocyanate groups of the lysine methyl-ester diisocyanate (LDI) and the hydroxyl groups of either (PEG) or PCL diol.
摘要翻译: 基于聚(ε-己内酯)(PCL)和聚(乙二醇)(PEG)多嵌段杂化热塑性聚氨酯的水触发形状记忆聚合物。 通过赖氨酸甲酯二异氰酸酯(LDI)的异氰酸酯基与(PEG)或PCL二醇的羟基之间的加成反应形成氨基甲酸酯键。
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公开(公告)号:US20160185985A1
公开(公告)日:2016-06-30
申请号:US14650791
申请日:2013-09-10
申请人: BYK-CHEMIE GMBH
发明人: Daniela LEUTFELD , René NAGELSDIEK , Jürgen OMEIS , Jasmin RUDNER
CPC分类号: C09D7/65 , C08G18/28 , C08G18/2825 , C08G18/283 , C08G18/284 , C08G18/3819 , C08G18/3825 , C08G18/7621 , C08G18/771 , C08G18/792 , C08G18/8064 , C08K5/20 , C08L75/02 , C08L75/04 , C09D5/04 , C09D17/002 , C10M161/00 , C10M2201/08 , C10M2215/08 , C10M2215/0806 , C10M2215/102 , C10M2217/0456 , C09D175/04 , C08L75/12 , C09D175/06
摘要: The present invention relates to a composition effective as a rheology additive containing 15-95 wt.-% of an oxygen compound (A), 5-75 wt.-% of a urea compound (B), 0-50 wt.-% of an ionogenic compound (C) and 0-35 wt.-% of an organic solvent (D).
摘要翻译: 本发明涉及作为流变助剂有效的组合物,其含有15-95重量%的氧化合物(A),5-75重量%的脲化合物(B),0-50重量% 的离子型化合物(C)和0-35重量%的有机溶剂(D)。
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公开(公告)号:US09328192B2
公开(公告)日:2016-05-03
申请号:US14645522
申请日:2015-03-12
发明人: Rao S Bezwada , Neeti Srivastava
IPC分类号: C08G18/76 , C08G71/02 , C08G69/00 , C08G73/02 , C08G18/60 , C08G18/77 , C08G18/81 , C07C265/14
CPC分类号: C08G18/7657 , C07C265/14 , C08G18/603 , C08G18/771 , C08G18/8125 , C08G69/00 , C08G71/02 , C08G73/02 , C08G2230/00 , Y10T428/1352 , Y10T428/1355 , Y10T428/1393 , Y10T428/24999 , Y10T428/249991 , Y10T428/2804 , Y10T428/2896 , Y10T428/31551 , Y10T428/31605 , Y10T442/20
摘要: Described are novel ricinoleic acid/12-hydroxy stearic acid-based diisocyanates, which are useful as monomers to form polymers, which have applications inter alia as medical devices.
摘要翻译: 描述了新颖的蓖麻油酸/ 12-羟基硬脂酸基二异氰酸酯,其可用作形成聚合物的单体,其尤其可用作医疗装置。
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