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公开(公告)号：US09139621B2
公开(公告)日：2015-09-22
申请号：US13070448
申请日：2011-03-23
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： C07K14/22 , A61K39/095 , A61K39/00 , A61K38/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US08524251B2
公开(公告)日：2013-09-03
申请号：US13359471
申请日：2012-01-26
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , A61K39/02 , A61K38/00 , C07K1/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20130005667A1
公开(公告)日：2013-01-03
申请号：US13340549
申请日：2011-12-29
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
IPC分类号： A61K38/16
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localisation, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US08287884B2
公开(公告)日：2012-10-16
申请号：US12573929
申请日：2009-10-06
申请人： Vega Masignani , Marirosa Mora , Maria Scarselli
发明人： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC分类号： A61K39/085 , C07K14/31 , C07H21/04
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus, including amino acid sequences and corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies, and as targets for antibiotics.
摘要翻译： 本发明提供了来自金黄色葡萄球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。 这些蛋白质可用于疫苗，免疫原性组合物，诊断，酶学研究和抗生素靶标。
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公开(公告)号：US20120052084A1
公开(公告)日：2012-03-01
申请号：US13292977
申请日：2011-11-09
申请人： Vega Masignani , Marirosa Mora , Maria Scarselli
发明人： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC分类号： A61K39/085 , A61K39/29 , A61K39/145 , A61K39/09 , A61P31/16 , A61K39/095 , A61P31/04 , A61P37/04 , A61P31/14 , A61P31/20 , C07K14/31 , A61K39/02
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US07714121B2
公开(公告)日：2010-05-11
申请号：US10695499
申请日：2003-10-28
IPC分类号： C07H21/04
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供来自脑膜炎奈瑟菌（A＆B）菌株的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号：US20090298099A1
公开(公告)日：2009-12-03
申请号：US12371691
申请日：2009-02-16
IPC分类号： G01N33/571 , C07K14/00 , C07K16/18 , C12N15/11
摘要： The invention provides proteins from gonococcus (Neisseria gonorrhoeae), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. They are also useful for distinguishing between gonococcus and meningococcus and, in particular, between gonococcus and serogroup B meningococcus.
摘要翻译： 本发明提供来自淋球菌（Neisseria gonorrhoeae）的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。 它们也可用于区分淋球菌和脑膜炎球菌，特别是在淋球菌和血清群B脑膜炎球菌之间。
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公开(公告)号：US07618636B1
公开(公告)日：2009-11-17
申请号：US10031289
申请日：2000-07-13
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , A61K2039/53 , Y10S530/825
摘要： WO99/36544 discloses a large number of proteins from Neisseria Meningitidis. The present invention relates to fragments of those proteins which comprise at least one antigenic determinant. Homologous sequences and proteins comprising these fragments are also disclosed.
摘要翻译： WO99 / 36544公开了大量来自脑膜炎奈瑟球菌的蛋白质。 本发明涉及包含至少一种抗原决定簇的那些蛋白质的片段。 还公开了包含这些片段的同源序列和蛋白质。
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公开(公告)号：US07612192B2
公开(公告)日：2009-11-03
申请号：US10915740
申请日：2004-08-11
申请人： Claire Marie Fraser , Erin Kathleen Hickey , Jeremy D. Peterson , Herve Tettelin , Craig Ventor , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
发明人： Claire Marie Fraser , Erin Kathleen Hickey , Jeremy D. Peterson , Herve Tettelin , Craig Ventor , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , C12Q1/689 , C12Q2600/156
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供了从包括奈瑟氏球菌在内的基因组序列获得免疫原性蛋白质的方法，包括氨基酸序列和相应的核苷酸序列，以及脑膜炎奈瑟氏球菌B的基因组序列。如此获得的蛋白质是疫苗，免疫原性组合物和 /或诊断。
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公开(公告)号：US20080267966A1
公开(公告)日：2008-10-30
申请号：US11596557
申请日：2005-05-16
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/505 , A61K2039/53
摘要： Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by H. influenzae, such as otitis media.
摘要翻译： 包含不可分型流感嗜血杆菌（NTHi）氨基酸序列的多肽。 公开了超过2500种特异性NTHi蛋白。 本发明还提供了相关的多肽，核酸，抗体和方法。 这些都可以用于治疗或预防由流感嗜血杆菌引起的疾病和/或感染的药物，例如中耳炎。
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