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18 条记录 (耗时 0.026 秒)

    Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Cancer
    6.
    发明申请
    Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Cancer 审中-公开
    细胞毒性T淋巴细胞诱导免疫原预防治疗和诊断癌症

    公开(公告)号：US20160022791A1

    公开(公告)日：2016-01-28

    申请号：US14819599

    申请日：2015-08-06

    申请人： Ramila Philip

    发明人： Ramila Philip

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K2039/572 ,  C07K14/4748 ,  G01N33/57423

    摘要： The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as lung carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against lung and other cancers.

    摘要翻译： 本发明涉及用于预防，治疗和诊断癌症，特别是癌症如肺癌的组合物和方法。 本发明公开了可用于刺激针对肺癌和其它癌症的CTL应答的肽，多肽和多核苷酸。

    Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity
    8.
    发明授权
    Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity 失效
    腺相关病毒脂质体及其在转染树突细胞中的用途，以刺激特异性免疫

    公开(公告)号：US06652850B1

    公开(公告)日：2003-11-25

    申请号：US09000003

    申请日：1998-06-15

    申请人： Ramila Philip ,  Jane S. Lebkowski

    发明人： Ramila Philip ,  Jane S. Lebkowski

    IPC分类号： A61K4800

    CPC分类号： C12N15/86 ,  A61K9/1272 ,  A61K47/6901 ,  A61K47/6911 ,  A61K48/00 ,  C07K14/47 ,  C07K14/55 ,  C07K14/70503 ,  C12N15/88 ,  C12N2710/10343 ,  C12N2750/14143

    摘要： A composition for genetic manipulation of cells comprises a liposome comprised of lipid material, and adeno-associated viral (AAV) material. Typically, the AAV material is plasmid, and comprises one or more terminal repeats of the AAV genome. Methods are disclosed for introducing DNA into cells using AAV/liposome complexes. The DNA is introduced and expressed in'stem cells, T cells, primary tumor cells, tumor cell lines and dendritic cells or other antigen-presenting cells. Such transfected cells are used in therapeutic methods to treat subjects with cancer or microbial infections. Dendritic cells with DNA encoding tumor or viral antigens and are used to treat subjects with tumors or viral infections by administration in vivo or by activation of antigen-specific lymphocytes ex vivo followed by administration of those lymphocytes to the subject.

    摘要翻译： 用于细胞遗传操作的组合物包括由脂质材料和腺相关病毒（AAV）材料组成的脂质体。 通常，AAV材料是质粒，并且包含AAV基因组的一个或多个末端重复序列。 公开了使用AAV /脂质体复合物将DNA引入细胞的方法。 引入DNA并在干细胞，T细胞，原代肿瘤细胞，肿瘤细胞系和树突状细胞或其他抗原呈递细胞中表达。 这种转染的细胞用于治疗患有癌症或微生物感染的受试者的治疗方法。 具有编码肿瘤或病毒抗原的DNA的树突状细胞用于通过在体内施用或通过在体外激活抗原特异性淋巴细胞来治疗患有肿瘤或病毒感染的受试者，然后向受试者施用那些淋巴细胞。