公开(公告)号：US06262098B1

公开(公告)日：2001-07-17

申请号：US09369748

申请日：1999-08-06

申请人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

发明人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

IPC分类号： A61K3142

CPC分类号： C07D261/10 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D413/04 ,  C07D413/12

摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

公开(公告)号：US06743815B2

公开(公告)日：2004-06-01

申请号：US10134302

申请日：2002-04-25

申请人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

发明人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

IPC分类号： A61K3142

CPC分类号： C07D261/10 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D413/04 ,  C07D413/12

摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

公开(公告)号：US06869969B2

公开(公告)日：2005-03-22

申请号：US10713621

申请日：2003-11-13

申请人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

发明人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

IPC分类号： A61K31/42 ,  A61K31/422 ,  A61K31/423 ,  A61K31/424 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4745 ,  A61P5/30 ,  A61P19/10 ,  A61P25/28 ,  A61P43/00 ,  C07D261/08 ,  C07D261/10 ,  C07D261/18 ,  C07D261/20 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D498/04 ,  C07D261/02 ,  C07D261/06

CPC分类号： C07D261/10 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D413/04 ,  C07D413/12

摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

摘要翻译： 描述了在调节雌激素受体活性方面具有出人意料的和惊人的活性的异恶唑雌激素受体激动剂和拮抗剂化合物。 此外，公开了治疗或预防雌激素受体介导的病症的方法和组合物。 本发明的化合物，方法和组合物可用于预防或治疗雌激素受体介导的障碍，例如骨质疏松症，乳腺和子宫内膜癌，动脉粥样硬化和阿尔茨海默氏病。

公开(公告)号：US06387920B2

公开(公告)日：2002-05-14

申请号：US09833392

申请日：2001-04-11

申请人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

发明人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

IPC分类号： A61K3144

CPC分类号： C07D261/10 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D413/04 ,  C07D413/12

摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

摘要翻译： 描述了在调节雌激素受体活性方面具有出人意料的和惊人的活性的异恶唑雌激素受体激动剂和拮抗剂化合物。 此外，公开了治疗或预防雌激素受体介导的病症的方法和组合物。 本发明的化合物，方法和组合物可用于预防或治疗雌激素受体介导的障碍，例如骨质疏松症，乳腺和子宫内膜癌，动脉粥样硬化和阿尔茨海默氏病。

公开(公告)号：US20080112938A1

公开(公告)日：2008-05-15

申请号：US11864435

申请日：2007-09-28

申请人： Ronald Li ,  Jennifer C. Moore

发明人： Ronald Li ,  Jennifer C. Moore

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C12N5/08

CPC分类号： A61K9/0004 ,  A61K9/1688 ,  A61K48/00 ,  C07K14/705 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2320/50

摘要： This invention provides a eukaryotic cell that stably expresses exogenous, ectopic SID-1 to confer enhanced polynucleotide, e.g. siRNA or dsRNA, uptake. Thus, in one aspect, this invention provides a eukaryotic cell which stably expresses exogenous SID-1 polynucleotide and is. The cells stably expressing SID-1 are particularly useful for high throughput screening of gene activity using RNA interference. Methods for producing and using the cells also are provided in this application.

摘要翻译： 本发明提供了稳定表达外源性异位SID-1以赋予增强多核苷酸的真核细胞，例如， siRNA或dsRNA，摄取。 因此，一方面，本发明提供了稳定表达外源SID-1多核苷酸的真核细胞。 稳定表达SID-1的细胞对于使用RNA干扰的基因活性的高通量筛选是特别有用的。 本申请中还提供了生产和使用细胞的方法。