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公开(公告)号：US06262098B1
公开(公告)日：2001-07-17
申请号：US09369748
申请日：1999-08-06
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
IPC分类号： A61K3142
CPC分类号： C07D261/10 , C07D261/08 , C07D261/18 , C07D261/20 , C07D413/04 , C07D413/12
摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
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公开(公告)号：US06743815B2
公开(公告)日：2004-06-01
申请号：US10134302
申请日：2002-04-25
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
IPC分类号： A61K3142
CPC分类号： C07D261/10 , C07D261/08 , C07D261/18 , C07D261/20 , C07D413/04 , C07D413/12
摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
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公开(公告)号：US06869969B2
公开(公告)日：2005-03-22
申请号：US10713621
申请日：2003-11-13
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
IPC分类号： A61K31/42 , A61K31/422 , A61K31/423 , A61K31/424 , A61K31/4433 , A61K31/4439 , A61K31/454 , A61K31/4745 , A61P5/30 , A61P19/10 , A61P25/28 , A61P43/00 , C07D261/08 , C07D261/10 , C07D261/18 , C07D261/20 , C07D409/04 , C07D413/04 , C07D413/12 , C07D498/04 , C07D261/02 , C07D261/06
CPC分类号： C07D261/10 , C07D261/08 , C07D261/18 , C07D261/20 , C07D413/04 , C07D413/12
摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
摘要翻译： 描述了在调节雌激素受体活性方面具有出人意料的和惊人的活性的异恶唑雌激素受体激动剂和拮抗剂化合物。 此外，公开了治疗或预防雌激素受体介导的病症的方法和组合物。 本发明的化合物，方法和组合物可用于预防或治疗雌激素受体介导的障碍，例如骨质疏松症，乳腺和子宫内膜癌，动脉粥样硬化和阿尔茨海默氏病。
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公开(公告)号：US06387920B2
公开(公告)日：2002-05-14
申请号：US09833392
申请日：2001-04-11
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Jennifer C. Moore , Beata Krywult , Thayalan Navaratnam , Rajinder Singh , Rob Trainor , Liang Wang
IPC分类号： A61K3144
CPC分类号： C07D261/10 , C07D261/08 , C07D261/18 , C07D261/20 , C07D413/04 , C07D413/12
摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
摘要翻译： 描述了在调节雌激素受体活性方面具有出人意料的和惊人的活性的异恶唑雌激素受体激动剂和拮抗剂化合物。 此外，公开了治疗或预防雌激素受体介导的病症的方法和组合物。 本发明的化合物，方法和组合物可用于预防或治疗雌激素受体介导的障碍，例如骨质疏松症，乳腺和子宫内膜癌，动脉粥样硬化和阿尔茨海默氏病。
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公开(公告)号：US06727273B2
公开(公告)日：2004-04-27
申请号：US09954039
申请日：2001-09-18
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
IPC分类号： A61K31416
CPC分类号： C07D261/08 , C07D231/12 , C07D231/54 , C07D261/10 , C07D261/18 , C07D261/20 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D413/12
摘要： Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
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公开(公告)号：US06291505B1
公开(公告)日：2001-09-18
申请号：US09369747
申请日：1999-08-06
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj Desai , Beata Krywult , Rajinder Singh , Liang Wang
IPC分类号： A61K31415
CPC分类号： C07D261/08 , C07D231/12 , C07D231/54 , C07D261/10 , C07D261/18 , C07D261/20 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D413/12
摘要： Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
摘要翻译： 除了用于治疗或预防雌激素受体介导的病症的方法和组合物之外还描述了雌激素受体调节性吡唑化合物。 已经发现所描述的化合物在调节雌激素受体活性方面具有意想不到的和惊人的活性。 因此，本发明的化合物可用于预防或治疗雌激素受体介导的疾病如骨质疏松症，乳腺癌和子宫内膜癌，动脉粥样硬化和阿尔茨海默氏病。
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公开(公告)号：USRE39708E1
公开(公告)日：2007-06-26
申请号：US10757347
申请日：2004-01-13
申请人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj C. Desai , Beata Krywult , Rajinder Singh , Liang Wang
发明人： Verena D. Huebner , Xiaodong Lin , Ian James , Liya Chen , Manoj C. Desai , Beata Krywult , Rajinder Singh , Liang Wang
IPC分类号： A61K31/415 , A61P19/10 , C07D231/12
CPC分类号： C07D401/04 , C07D231/12 , C07D231/54 , C07D403/04 , C07D409/04
摘要： Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
摘要翻译： 除了用于治疗或预防雌激素受体介导的病症的方法和组合物之外还描述了雌激素受体调节性吡唑化合物。 已经发现所描述的化合物在调节雌激素受体活性方面具有意想不到的和惊人的活性。 因此，本发明的化合物可用于预防或治疗雌激素受体介导的疾病如骨质疏松症，乳腺癌和子宫内膜癌，动脉粥样硬化和阿尔茨海默氏病。
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公开(公告)号：US20180312623A1
公开(公告)日：2018-11-01
申请号：US15582362
申请日：2017-04-28
申请人： Liang Wang , Viktoria Wang
发明人： Liang Wang , Viktoria Wang
摘要： The present invention relates to polyurethane-urea elastomers with exceptional mechanical properties and enhanced elasticity based on molecular structure analysis. The present invention involves the synthesis of a polyurethane-urea elastomer using a combination of commercially available materials: (1) polyols with ultralow unsaturation and narrow polydispersity, (2) diisocyanates with symmetric steric conformation, and (3) bulky diamines between functional groups. The preparation method for the novel polyurethane-urea is disclosed. The subject elastomers have the highest reported elongation-at-break among known polyurethane elastomers.
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公开(公告)号：US09670304B2
公开(公告)日：2017-06-06
申请号：US13669131
申请日：2012-11-05
申请人： Liang Wang , Viktoria Ren Wang
发明人： Liang Wang , Viktoria Ren Wang
CPC分类号： C08G18/06 , C08J7/042 , C08J7/047 , C08J2483/04 , Y10T428/31544 , Y10T428/31573 , Y10T428/31663
摘要： The present invention relates to a novel composite for preventing ice adhesion. A superhydrophobic or superhydrophilic surface with a hydrophobic, low freezing point liquid adsorbed onto surface asperities results in a durable, renewable anti-icing surface. The preparation method for novel icing and rain protecting surface is disclosed.
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公开(公告)号：US09196765B2
公开(公告)日：2015-11-24
申请号：US14716233
申请日：2015-05-19
申请人： Shuqiang Yang , Michael N. Miller , Mohamed M. Hilali , Fen Wan , Gerard M. Schmid , Liang Wang , Sidlgata V. Sreenivasan , Frank Y. Xu
发明人： Shuqiang Yang , Michael N. Miller , Mohamed M. Hilali , Fen Wan , Gerard M. Schmid , Liang Wang , Sidlgata V. Sreenivasan , Frank Y. Xu
IPC分类号： H01L31/0236 , C23C14/34 , H01L31/20
CPC分类号： H01L31/02363 , B82Y20/00 , C23C14/34 , H01L31/022466 , H01L31/0236 , H01L31/035263 , H01L31/035281 , H01L31/03762 , H01L31/0392 , H01L31/03921 , H01L31/03926 , H01L31/0463 , H01L31/075 , H01L31/076 , H01L31/202 , Y02E10/548 , Y02P70/521
摘要： Systems and methods for fabrication of nanostructured solar cells having arrays of nanostructures are described, including nanostructured solar cells having a repeating pattern of pyramid nanostructures, providing for low cost thin-film solar cells with improved PCE.
摘要翻译： 描述了具有纳米结构阵列的纳米结构太阳能电池的制造系统和方法，包括具有金字塔纳米结构重复图案的纳米结构太阳能电池，为具有改进的PCE的低成本薄膜太阳能电池提供。
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